Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1159/000343309 http://hdl.handle.net/11449/18293 |
Resumo: | Background/Aims: Renin-angiotensin-aldosterone system blockade with a mineralocorticoid-receptor antagonist has not yet been studied in exposure to tobacco smoke (TS) models. Thus, this study investigated the role of spironolactone on cardiac remodeling induced by exposure to tobacco smoke. Methods: Male Wistar rats were divided into 4 groups: a control group (group C, n=11); a group with 2 months of cigarette smoke exposure (group TS-C, n=13); a group that received spironolactone 20 mg/kg of diet/day and no cigarette smoke exposure (group TS-S, n=13); and a group with 2 months of cigarette smoke exposure and spironolactone supplementation (group S, n=12). The rats were observed for a period of 60 days, during which morphological, biochemical and functional analyses were performed. Results: There was no difference in invasive mean arterial pressure among the groups. There were no interactions between tobacco smoke exposure and spironolactone in the morphological and functional analysis. However, in the echocardiographic analysis, the TS groups had left chamber enlargement, higher left ventricular mass index and higher isovolumetric relaxation time corrected by heart rate compared with the non-TS groups. In vitro left ventricular diastolic function also worsened in the IS groups and was not influenced by spironolactone. In addition, there were no differences in myocardial levels of IFN-gamma, TNF-alpha, IL-10, ICAM-1 and GLUT4 [TS: OR 0.52, 95%CI (-0.007; 0.11); Spironolactone: OR -0.01, 95%CI (-0.07;0.05)]. Conclusion: Our data do not support the participation of aldosterone in the ventricular remodeling process induced by exposed to cigarette smoke. Copyright (C) 2012 S. Karger AG, Basel |
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Repositório Institucional da UNESP |
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Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke ExposureGLUT4InflammationVentricular remodelingCigarette smokeBackground/Aims: Renin-angiotensin-aldosterone system blockade with a mineralocorticoid-receptor antagonist has not yet been studied in exposure to tobacco smoke (TS) models. Thus, this study investigated the role of spironolactone on cardiac remodeling induced by exposure to tobacco smoke. Methods: Male Wistar rats were divided into 4 groups: a control group (group C, n=11); a group with 2 months of cigarette smoke exposure (group TS-C, n=13); a group that received spironolactone 20 mg/kg of diet/day and no cigarette smoke exposure (group TS-S, n=13); and a group with 2 months of cigarette smoke exposure and spironolactone supplementation (group S, n=12). The rats were observed for a period of 60 days, during which morphological, biochemical and functional analyses were performed. Results: There was no difference in invasive mean arterial pressure among the groups. There were no interactions between tobacco smoke exposure and spironolactone in the morphological and functional analysis. However, in the echocardiographic analysis, the TS groups had left chamber enlargement, higher left ventricular mass index and higher isovolumetric relaxation time corrected by heart rate compared with the non-TS groups. In vitro left ventricular diastolic function also worsened in the IS groups and was not influenced by spironolactone. In addition, there were no differences in myocardial levels of IFN-gamma, TNF-alpha, IL-10, ICAM-1 and GLUT4 [TS: OR 0.52, 95%CI (-0.007; 0.11); Spironolactone: OR -0.01, 95%CI (-0.07;0.05)]. Conclusion: Our data do not support the participation of aldosterone in the ventricular remodeling process induced by exposed to cigarette smoke. Copyright (C) 2012 S. Karger AG, BaselFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, BrazilSão Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, BrazilUniv Estadual Paulista UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, BrazilSão Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, BrazilFAPESP: 10/10187-2CNPq: 473091/2010-0KargerUniversidade Estadual Paulista (Unesp)dos Santos, Priscila P. [UNESP]Nogueira, Bruna F. [UNESP]Rafacho, Bruna P. M. [UNESP]Gaiolla, Paula Schmidt Azevedo [UNESP]Polegato, Bertha Furlan [UNESP]Chiuso-Minicucci, Fernanda [UNESP]Bonomo, Camila [UNESP]Roscani, Meliza Goi [UNESP]Zorzella-Pezavento, Sofia F. G. [UNESP]Tanni, Suzana E. [UNESP]Pereira, Elenize J. [UNESP]Okoshi, Marina Politi [UNESP]Paiva, Sergio Alberto Rupp de [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]Minicucci, Marcos Ferreira [UNESP]2014-05-20T13:51:15Z2014-05-20T13:51:15Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1191-1201application/pdfhttp://dx.doi.org/10.1159/000343309Cellular Physiology and Biochemistry. Basel: Karger, v. 30, n. 5, p. 1191-1201, 2012.1015-8987http://hdl.handle.net/11449/1829310.1159/000343309WOS:000312617200009WOS000312617200009.pdf44631386719984325016839015394547[12]121314080140264774387040344716730000-0002-9831-88200000-0002-9831-8820[12]0000-0002-5843-6232Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCellular Physiology and Biochemistry5.5001,561info:eu-repo/semantics/openAccess2024-01-18T06:24:20Zoai:repositorio.unesp.br:11449/18293Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-18T06:24:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure |
title |
Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure |
spellingShingle |
Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure dos Santos, Priscila P. [UNESP] GLUT4 Inflammation Ventricular remodeling Cigarette smoke |
title_short |
Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure |
title_full |
Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure |
title_fullStr |
Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure |
title_full_unstemmed |
Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure |
title_sort |
Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure |
author |
dos Santos, Priscila P. [UNESP] |
author_facet |
dos Santos, Priscila P. [UNESP] Nogueira, Bruna F. [UNESP] Rafacho, Bruna P. M. [UNESP] Gaiolla, Paula Schmidt Azevedo [UNESP] Polegato, Bertha Furlan [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Bonomo, Camila [UNESP] Roscani, Meliza Goi [UNESP] Zorzella-Pezavento, Sofia F. G. [UNESP] Tanni, Suzana E. [UNESP] Pereira, Elenize J. [UNESP] Okoshi, Marina Politi [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Minicucci, Marcos Ferreira [UNESP] |
author_role |
author |
author2 |
Nogueira, Bruna F. [UNESP] Rafacho, Bruna P. M. [UNESP] Gaiolla, Paula Schmidt Azevedo [UNESP] Polegato, Bertha Furlan [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Bonomo, Camila [UNESP] Roscani, Meliza Goi [UNESP] Zorzella-Pezavento, Sofia F. G. [UNESP] Tanni, Suzana E. [UNESP] Pereira, Elenize J. [UNESP] Okoshi, Marina Politi [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Minicucci, Marcos Ferreira [UNESP] |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
dos Santos, Priscila P. [UNESP] Nogueira, Bruna F. [UNESP] Rafacho, Bruna P. M. [UNESP] Gaiolla, Paula Schmidt Azevedo [UNESP] Polegato, Bertha Furlan [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Bonomo, Camila [UNESP] Roscani, Meliza Goi [UNESP] Zorzella-Pezavento, Sofia F. G. [UNESP] Tanni, Suzana E. [UNESP] Pereira, Elenize J. [UNESP] Okoshi, Marina Politi [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] Minicucci, Marcos Ferreira [UNESP] |
dc.subject.por.fl_str_mv |
GLUT4 Inflammation Ventricular remodeling Cigarette smoke |
topic |
GLUT4 Inflammation Ventricular remodeling Cigarette smoke |
description |
Background/Aims: Renin-angiotensin-aldosterone system blockade with a mineralocorticoid-receptor antagonist has not yet been studied in exposure to tobacco smoke (TS) models. Thus, this study investigated the role of spironolactone on cardiac remodeling induced by exposure to tobacco smoke. Methods: Male Wistar rats were divided into 4 groups: a control group (group C, n=11); a group with 2 months of cigarette smoke exposure (group TS-C, n=13); a group that received spironolactone 20 mg/kg of diet/day and no cigarette smoke exposure (group TS-S, n=13); and a group with 2 months of cigarette smoke exposure and spironolactone supplementation (group S, n=12). The rats were observed for a period of 60 days, during which morphological, biochemical and functional analyses were performed. Results: There was no difference in invasive mean arterial pressure among the groups. There were no interactions between tobacco smoke exposure and spironolactone in the morphological and functional analysis. However, in the echocardiographic analysis, the TS groups had left chamber enlargement, higher left ventricular mass index and higher isovolumetric relaxation time corrected by heart rate compared with the non-TS groups. In vitro left ventricular diastolic function also worsened in the IS groups and was not influenced by spironolactone. In addition, there were no differences in myocardial levels of IFN-gamma, TNF-alpha, IL-10, ICAM-1 and GLUT4 [TS: OR 0.52, 95%CI (-0.007; 0.11); Spironolactone: OR -0.01, 95%CI (-0.07;0.05)]. Conclusion: Our data do not support the participation of aldosterone in the ventricular remodeling process induced by exposed to cigarette smoke. Copyright (C) 2012 S. Karger AG, Basel |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2014-05-20T13:51:15Z 2014-05-20T13:51:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1159/000343309 Cellular Physiology and Biochemistry. Basel: Karger, v. 30, n. 5, p. 1191-1201, 2012. 1015-8987 http://hdl.handle.net/11449/18293 10.1159/000343309 WOS:000312617200009 WOS000312617200009.pdf 4463138671998432 5016839015394547[12] 1213140801402647 7438704034471673 0000-0002-9831-8820 0000-0002-9831-8820[12] 0000-0002-5843-6232 |
url |
http://dx.doi.org/10.1159/000343309 http://hdl.handle.net/11449/18293 |
identifier_str_mv |
Cellular Physiology and Biochemistry. Basel: Karger, v. 30, n. 5, p. 1191-1201, 2012. 1015-8987 10.1159/000343309 WOS:000312617200009 WOS000312617200009.pdf 4463138671998432 5016839015394547[12] 1213140801402647 7438704034471673 0000-0002-9831-8820 0000-0002-9831-8820[12] 0000-0002-5843-6232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cellular Physiology and Biochemistry 5.500 1,561 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1191-1201 application/pdf |
dc.publisher.none.fl_str_mv |
Karger |
publisher.none.fl_str_mv |
Karger |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965652978499584 |