Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/jre.13026 http://hdl.handle.net/11449/242075 |
Resumo: | Background: The purpose of this preclinical study was to evaluate the influence of tamoxifen (TAM) on the peri-implant bone remodeling of osseointegrated titanium implants in ovariectomized female rats. Materials and Methods: Seventy-two female rats underwent bilateral ovariectomy 20 weeks before implants placement. One titanium implant was inserted in each tibia of the animals. Six weeks following the implant surgery, animals were randomly divided into two experimental groups (n = 36), which received either saline solution (SS) or tamoxifen citrate (TAM) via gavage until euthanasia. Euthanasia was performed at 30, 60, and 90 days after the first gavage. Assessments of bone to implant contact (BIC), bone ingrowth percentage (BIN), morphological description of cellular and tissue reactions, immunohistochemistry for the detection of bone morphogenetic protein 2/4 (BMP2/4), runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP), and bone chemical composition through scanning electron microscopy with energy-dispersive x-ray spectroscopy were performed. Results: Tamoxifen group presented higher BIC, higher BIN, higher RUNX-2 and OCN, lower TRAP-positive cells/mm2, and no differences regarding BMP-2/4 positive cells/mm2 than SS group in all periods. TAM group also showed higher Ca/P rate than SS group. Conclusion: Tamoxifen enhanced the remodeling of the bone surrounding titanium implants in ovariectomized rats. |
id |
UNSP_c8306cf37f8afe8d0938c08aa704e3d8 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/242075 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implantsbone remodelingdental implantsselective estrogen receptor modulatorstamoxifenBackground: The purpose of this preclinical study was to evaluate the influence of tamoxifen (TAM) on the peri-implant bone remodeling of osseointegrated titanium implants in ovariectomized female rats. Materials and Methods: Seventy-two female rats underwent bilateral ovariectomy 20 weeks before implants placement. One titanium implant was inserted in each tibia of the animals. Six weeks following the implant surgery, animals were randomly divided into two experimental groups (n = 36), which received either saline solution (SS) or tamoxifen citrate (TAM) via gavage until euthanasia. Euthanasia was performed at 30, 60, and 90 days after the first gavage. Assessments of bone to implant contact (BIC), bone ingrowth percentage (BIN), morphological description of cellular and tissue reactions, immunohistochemistry for the detection of bone morphogenetic protein 2/4 (BMP2/4), runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP), and bone chemical composition through scanning electron microscopy with energy-dispersive x-ray spectroscopy were performed. Results: Tamoxifen group presented higher BIC, higher BIN, higher RUNX-2 and OCN, lower TRAP-positive cells/mm2, and no differences regarding BMP-2/4 positive cells/mm2 than SS group in all periods. TAM group also showed higher Ca/P rate than SS group. Conclusion: Tamoxifen enhanced the remodeling of the bone surrounding titanium implants in ovariectomized rats.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Department of Diagnosis and Surgery Division of Periodontics São Paulo State University “Júlio de Mesquita Filho” (UNESP)Nucleus of Study and Research in Periodontics and Implantology (NEPPI) School of Dentistry Sao Paulo State University (UNESP)Department of Basics Sciences Clinic Araçatuba School of Dentistry Sao Paulo Sao Paulo State University (UNESP)Thin Section Laboratory Department of Biomedical Surgical and Dental Sciences Università degli Studi di Milano Statale (UNIMI)Implant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCCS Ca 'Granda Ospedale Maggiore PoliclinicoDepartment of Diagnosis and Surgery Division of Periodontics São Paulo State University “Júlio de Mesquita Filho” (UNESP)Nucleus of Study and Research in Periodontics and Implantology (NEPPI) School of Dentistry Sao Paulo State University (UNESP)Department of Basics Sciences Clinic Araçatuba School of Dentistry Sao Paulo Sao Paulo State University (UNESP)CAPES: FinanceCode001Universidade Estadual Paulista (UNESP)Università degli Studi di Milano Statale (UNIMI)Fondazione IRCCS Ca 'Granda Ospedale Maggiore PoliclinicoFiorin, Luiz Guilherme [UNESP]Matheus, Henrique Rinaldi [UNESP]Ervolino, Edilson [UNESP]Canciani, ElenaPellegrini, GaiaDellavia, ClaudiaMaiorana, Carlode Almeida, Juliano Milanezi [UNESP]2023-03-02T08:37:27Z2023-03-02T08:37:27Z2022-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article880-890http://dx.doi.org/10.1111/jre.13026Journal of Periodontal Research, v. 57, n. 4, p. 880-890, 2022.1600-07650022-3484http://hdl.handle.net/11449/24207510.1111/jre.130262-s2.0-85134854564Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Periodontal Researchinfo:eu-repo/semantics/openAccess2024-09-19T14:02:31Zoai:repositorio.unesp.br:11449/242075Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T14:02:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants |
title |
Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants |
spellingShingle |
Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants Fiorin, Luiz Guilherme [UNESP] bone remodeling dental implants selective estrogen receptor modulators tamoxifen |
title_short |
Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants |
title_full |
Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants |
title_fullStr |
Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants |
title_full_unstemmed |
Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants |
title_sort |
Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants |
author |
Fiorin, Luiz Guilherme [UNESP] |
author_facet |
Fiorin, Luiz Guilherme [UNESP] Matheus, Henrique Rinaldi [UNESP] Ervolino, Edilson [UNESP] Canciani, Elena Pellegrini, Gaia Dellavia, Claudia Maiorana, Carlo de Almeida, Juliano Milanezi [UNESP] |
author_role |
author |
author2 |
Matheus, Henrique Rinaldi [UNESP] Ervolino, Edilson [UNESP] Canciani, Elena Pellegrini, Gaia Dellavia, Claudia Maiorana, Carlo de Almeida, Juliano Milanezi [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Università degli Studi di Milano Statale (UNIMI) Fondazione IRCCS Ca 'Granda Ospedale Maggiore Policlinico |
dc.contributor.author.fl_str_mv |
Fiorin, Luiz Guilherme [UNESP] Matheus, Henrique Rinaldi [UNESP] Ervolino, Edilson [UNESP] Canciani, Elena Pellegrini, Gaia Dellavia, Claudia Maiorana, Carlo de Almeida, Juliano Milanezi [UNESP] |
dc.subject.por.fl_str_mv |
bone remodeling dental implants selective estrogen receptor modulators tamoxifen |
topic |
bone remodeling dental implants selective estrogen receptor modulators tamoxifen |
description |
Background: The purpose of this preclinical study was to evaluate the influence of tamoxifen (TAM) on the peri-implant bone remodeling of osseointegrated titanium implants in ovariectomized female rats. Materials and Methods: Seventy-two female rats underwent bilateral ovariectomy 20 weeks before implants placement. One titanium implant was inserted in each tibia of the animals. Six weeks following the implant surgery, animals were randomly divided into two experimental groups (n = 36), which received either saline solution (SS) or tamoxifen citrate (TAM) via gavage until euthanasia. Euthanasia was performed at 30, 60, and 90 days after the first gavage. Assessments of bone to implant contact (BIC), bone ingrowth percentage (BIN), morphological description of cellular and tissue reactions, immunohistochemistry for the detection of bone morphogenetic protein 2/4 (BMP2/4), runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP), and bone chemical composition through scanning electron microscopy with energy-dispersive x-ray spectroscopy were performed. Results: Tamoxifen group presented higher BIC, higher BIN, higher RUNX-2 and OCN, lower TRAP-positive cells/mm2, and no differences regarding BMP-2/4 positive cells/mm2 than SS group in all periods. TAM group also showed higher Ca/P rate than SS group. Conclusion: Tamoxifen enhanced the remodeling of the bone surrounding titanium implants in ovariectomized rats. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-01 2023-03-02T08:37:27Z 2023-03-02T08:37:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/jre.13026 Journal of Periodontal Research, v. 57, n. 4, p. 880-890, 2022. 1600-0765 0022-3484 http://hdl.handle.net/11449/242075 10.1111/jre.13026 2-s2.0-85134854564 |
url |
http://dx.doi.org/10.1111/jre.13026 http://hdl.handle.net/11449/242075 |
identifier_str_mv |
Journal of Periodontal Research, v. 57, n. 4, p. 880-890, 2022. 1600-0765 0022-3484 10.1111/jre.13026 2-s2.0-85134854564 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Periodontal Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
880-890 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546395899002880 |