Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants

Detalhes bibliográficos
Autor(a) principal: Fiorin, Luiz Guilherme [UNESP]
Data de Publicação: 2022
Outros Autores: Matheus, Henrique Rinaldi [UNESP], Ervolino, Edilson [UNESP], Canciani, Elena, Pellegrini, Gaia, Dellavia, Claudia, Maiorana, Carlo, de Almeida, Juliano Milanezi [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/jre.13026
http://hdl.handle.net/11449/242075
Resumo: Background: The purpose of this preclinical study was to evaluate the influence of tamoxifen (TAM) on the peri-implant bone remodeling of osseointegrated titanium implants in ovariectomized female rats. Materials and Methods: Seventy-two female rats underwent bilateral ovariectomy 20 weeks before implants placement. One titanium implant was inserted in each tibia of the animals. Six weeks following the implant surgery, animals were randomly divided into two experimental groups (n = 36), which received either saline solution (SS) or tamoxifen citrate (TAM) via gavage until euthanasia. Euthanasia was performed at 30, 60, and 90 days after the first gavage. Assessments of bone to implant contact (BIC), bone ingrowth percentage (BIN), morphological description of cellular and tissue reactions, immunohistochemistry for the detection of bone morphogenetic protein 2/4 (BMP2/4), runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP), and bone chemical composition through scanning electron microscopy with energy-dispersive x-ray spectroscopy were performed. Results: Tamoxifen group presented higher BIC, higher BIN, higher RUNX-2 and OCN, lower TRAP-positive cells/mm2, and no differences regarding BMP-2/4 positive cells/mm2 than SS group in all periods. TAM group also showed higher Ca/P rate than SS group. Conclusion: Tamoxifen enhanced the remodeling of the bone surrounding titanium implants in ovariectomized rats.
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spelling Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implantsbone remodelingdental implantsselective estrogen receptor modulatorstamoxifenBackground: The purpose of this preclinical study was to evaluate the influence of tamoxifen (TAM) on the peri-implant bone remodeling of osseointegrated titanium implants in ovariectomized female rats. Materials and Methods: Seventy-two female rats underwent bilateral ovariectomy 20 weeks before implants placement. One titanium implant was inserted in each tibia of the animals. Six weeks following the implant surgery, animals were randomly divided into two experimental groups (n = 36), which received either saline solution (SS) or tamoxifen citrate (TAM) via gavage until euthanasia. Euthanasia was performed at 30, 60, and 90 days after the first gavage. Assessments of bone to implant contact (BIC), bone ingrowth percentage (BIN), morphological description of cellular and tissue reactions, immunohistochemistry for the detection of bone morphogenetic protein 2/4 (BMP2/4), runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP), and bone chemical composition through scanning electron microscopy with energy-dispersive x-ray spectroscopy were performed. Results: Tamoxifen group presented higher BIC, higher BIN, higher RUNX-2 and OCN, lower TRAP-positive cells/mm2, and no differences regarding BMP-2/4 positive cells/mm2 than SS group in all periods. TAM group also showed higher Ca/P rate than SS group. Conclusion: Tamoxifen enhanced the remodeling of the bone surrounding titanium implants in ovariectomized rats.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Department of Diagnosis and Surgery Division of Periodontics São Paulo State University “Júlio de Mesquita Filho” (UNESP)Nucleus of Study and Research in Periodontics and Implantology (NEPPI) School of Dentistry Sao Paulo State University (UNESP)Department of Basics Sciences Clinic Araçatuba School of Dentistry Sao Paulo Sao Paulo State University (UNESP)Thin Section Laboratory Department of Biomedical Surgical and Dental Sciences Università degli Studi di Milano Statale (UNIMI)Implant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCCS Ca 'Granda Ospedale Maggiore PoliclinicoDepartment of Diagnosis and Surgery Division of Periodontics São Paulo State University “Júlio de Mesquita Filho” (UNESP)Nucleus of Study and Research in Periodontics and Implantology (NEPPI) School of Dentistry Sao Paulo State University (UNESP)Department of Basics Sciences Clinic Araçatuba School of Dentistry Sao Paulo Sao Paulo State University (UNESP)CAPES: FinanceCode001Universidade Estadual Paulista (UNESP)Università degli Studi di Milano Statale (UNIMI)Fondazione IRCCS Ca 'Granda Ospedale Maggiore PoliclinicoFiorin, Luiz Guilherme [UNESP]Matheus, Henrique Rinaldi [UNESP]Ervolino, Edilson [UNESP]Canciani, ElenaPellegrini, GaiaDellavia, ClaudiaMaiorana, Carlode Almeida, Juliano Milanezi [UNESP]2023-03-02T08:37:27Z2023-03-02T08:37:27Z2022-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article880-890http://dx.doi.org/10.1111/jre.13026Journal of Periodontal Research, v. 57, n. 4, p. 880-890, 2022.1600-07650022-3484http://hdl.handle.net/11449/24207510.1111/jre.130262-s2.0-85134854564Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Periodontal Researchinfo:eu-repo/semantics/openAccess2024-09-19T14:02:31Zoai:repositorio.unesp.br:11449/242075Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T14:02:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants
title Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants
spellingShingle Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants
Fiorin, Luiz Guilherme [UNESP]
bone remodeling
dental implants
selective estrogen receptor modulators
tamoxifen
title_short Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants
title_full Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants
title_fullStr Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants
title_full_unstemmed Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants
title_sort Tamoxifen improves homeostasis in the peri-implant bone remodeling of osseointegrated titanium implants
author Fiorin, Luiz Guilherme [UNESP]
author_facet Fiorin, Luiz Guilherme [UNESP]
Matheus, Henrique Rinaldi [UNESP]
Ervolino, Edilson [UNESP]
Canciani, Elena
Pellegrini, Gaia
Dellavia, Claudia
Maiorana, Carlo
de Almeida, Juliano Milanezi [UNESP]
author_role author
author2 Matheus, Henrique Rinaldi [UNESP]
Ervolino, Edilson [UNESP]
Canciani, Elena
Pellegrini, Gaia
Dellavia, Claudia
Maiorana, Carlo
de Almeida, Juliano Milanezi [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Università degli Studi di Milano Statale (UNIMI)
Fondazione IRCCS Ca 'Granda Ospedale Maggiore Policlinico
dc.contributor.author.fl_str_mv Fiorin, Luiz Guilherme [UNESP]
Matheus, Henrique Rinaldi [UNESP]
Ervolino, Edilson [UNESP]
Canciani, Elena
Pellegrini, Gaia
Dellavia, Claudia
Maiorana, Carlo
de Almeida, Juliano Milanezi [UNESP]
dc.subject.por.fl_str_mv bone remodeling
dental implants
selective estrogen receptor modulators
tamoxifen
topic bone remodeling
dental implants
selective estrogen receptor modulators
tamoxifen
description Background: The purpose of this preclinical study was to evaluate the influence of tamoxifen (TAM) on the peri-implant bone remodeling of osseointegrated titanium implants in ovariectomized female rats. Materials and Methods: Seventy-two female rats underwent bilateral ovariectomy 20 weeks before implants placement. One titanium implant was inserted in each tibia of the animals. Six weeks following the implant surgery, animals were randomly divided into two experimental groups (n = 36), which received either saline solution (SS) or tamoxifen citrate (TAM) via gavage until euthanasia. Euthanasia was performed at 30, 60, and 90 days after the first gavage. Assessments of bone to implant contact (BIC), bone ingrowth percentage (BIN), morphological description of cellular and tissue reactions, immunohistochemistry for the detection of bone morphogenetic protein 2/4 (BMP2/4), runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP), and bone chemical composition through scanning electron microscopy with energy-dispersive x-ray spectroscopy were performed. Results: Tamoxifen group presented higher BIC, higher BIN, higher RUNX-2 and OCN, lower TRAP-positive cells/mm2, and no differences regarding BMP-2/4 positive cells/mm2 than SS group in all periods. TAM group also showed higher Ca/P rate than SS group. Conclusion: Tamoxifen enhanced the remodeling of the bone surrounding titanium implants in ovariectomized rats.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-01
2023-03-02T08:37:27Z
2023-03-02T08:37:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/jre.13026
Journal of Periodontal Research, v. 57, n. 4, p. 880-890, 2022.
1600-0765
0022-3484
http://hdl.handle.net/11449/242075
10.1111/jre.13026
2-s2.0-85134854564
url http://dx.doi.org/10.1111/jre.13026
http://hdl.handle.net/11449/242075
identifier_str_mv Journal of Periodontal Research, v. 57, n. 4, p. 880-890, 2022.
1600-0765
0022-3484
10.1111/jre.13026
2-s2.0-85134854564
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Periodontal Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 880-890
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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