Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1097/DSS.0000000000002990 http://hdl.handle.net/11449/229142 |
Resumo: | BACKGROUND: Croton oil (CO) is used by dermatologists and plastic surgeons in deep chemical peels. It is mixed with phenol, water, and a soap in Baker-Gordon's or Hetter's formulas. There is controversy as to whether CO or phenol is the active agent in the dermal effect of deep chemical peels. OBJECTIVE: To better clarify the role of CO in deep peels, by identification of active compounds in commercially available CO in the United States and biological effects in vivo. MATERIALS AND METHODS: Liquid chromatography-tandem mass spectrometry on CO and a domestic pig model experiment using 3 different formulas: G1: 5% Septisol (SEP), G2: 1.6% croton oil in 35% phenol with 5% SEP, and G3: 35% phenol with 5% SEP. RESULTS: Liquid chromatography-tandem mass spectrometry indicated the presence of phorbol esters. G1 was null overall. Extent of the coagulative necrosis: G2 > G3. Vascular ectasia: G2 > G3. Inflammation pattern: intense neutrophilic inflammatory band in G2 versus mild, sparse, perivascular mononuclear cell infiltrate in G3. Neocollagenesis: pronounced in G2, negligible in G3. CONCLUSION: Coagulative necrosis of the epidermis, superficial fibroblasts, and vasculature can be attributed to the action of phenol. Phorbol esters on CO could be responsible for the dense deep acute inflammation and the distinctive neocollagenesis. |
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spelling |
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical PeelsBACKGROUND: Croton oil (CO) is used by dermatologists and plastic surgeons in deep chemical peels. It is mixed with phenol, water, and a soap in Baker-Gordon's or Hetter's formulas. There is controversy as to whether CO or phenol is the active agent in the dermal effect of deep chemical peels. OBJECTIVE: To better clarify the role of CO in deep peels, by identification of active compounds in commercially available CO in the United States and biological effects in vivo. MATERIALS AND METHODS: Liquid chromatography-tandem mass spectrometry on CO and a domestic pig model experiment using 3 different formulas: G1: 5% Septisol (SEP), G2: 1.6% croton oil in 35% phenol with 5% SEP, and G3: 35% phenol with 5% SEP. RESULTS: Liquid chromatography-tandem mass spectrometry indicated the presence of phorbol esters. G1 was null overall. Extent of the coagulative necrosis: G2 > G3. Vascular ectasia: G2 > G3. Inflammation pattern: intense neutrophilic inflammatory band in G2 versus mild, sparse, perivascular mononuclear cell infiltrate in G3. Neocollagenesis: pronounced in G2, negligible in G3. CONCLUSION: Coagulative necrosis of the epidermis, superficial fibroblasts, and vasculature can be attributed to the action of phenol. Phorbol esters on CO could be responsible for the dense deep acute inflammation and the distinctive neocollagenesis.Departments of Pharmaceutical SciencesMedicineDentistryLaboratory of Research of SEBISA State University of Ponta GrossaLaboratory Fenn of Massachusetts Spectrometry Federal University of ParanáDepartment of Dermatology Warren Alpert Medical School of Brown UniversityDepartment of Dermatology and Radiotherapy Sao Paulo State University (UNESP)Department of Dermatology and Radiotherapy Sao Paulo State University (UNESP)MedicineDentistryState University of Ponta GrossaFederal University of ParanáWarren Alpert Medical School of Brown UniversityUniversidade Estadual Paulista (UNESP)Justo, Aline S.Lemes, Bruna M.Nunes, BrunaAntunes, Kevin A.Capote, Anna Claudia M OLipinski, Leandro C.Campagnoli, Eduardo B.Emiliano, JanainaMeurer, Eduardo C.Ezemma, OgechiMiot, Helio A. [UNESP]Beltrame, Flávio LWambier, Carlos G.2022-04-29T08:30:42Z2022-04-29T08:30:42Z2021-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article944-946http://dx.doi.org/10.1097/DSS.0000000000002990Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], v. 47, n. 7, p. 944-946, 2021.1524-4725http://hdl.handle.net/11449/22914210.1097/DSS.00000000000029902-s2.0-85110251582Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]info:eu-repo/semantics/openAccess2024-08-14T18:46:09Zoai:repositorio.unesp.br:11449/229142Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T18:46:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels |
title |
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels |
spellingShingle |
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels Justo, Aline S. |
title_short |
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels |
title_full |
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels |
title_fullStr |
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels |
title_full_unstemmed |
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels |
title_sort |
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels |
author |
Justo, Aline S. |
author_facet |
Justo, Aline S. Lemes, Bruna M. Nunes, Bruna Antunes, Kevin A. Capote, Anna Claudia M O Lipinski, Leandro C. Campagnoli, Eduardo B. Emiliano, Janaina Meurer, Eduardo C. Ezemma, Ogechi Miot, Helio A. [UNESP] Beltrame, Flávio L Wambier, Carlos G. |
author_role |
author |
author2 |
Lemes, Bruna M. Nunes, Bruna Antunes, Kevin A. Capote, Anna Claudia M O Lipinski, Leandro C. Campagnoli, Eduardo B. Emiliano, Janaina Meurer, Eduardo C. Ezemma, Ogechi Miot, Helio A. [UNESP] Beltrame, Flávio L Wambier, Carlos G. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Medicine Dentistry State University of Ponta Grossa Federal University of Paraná Warren Alpert Medical School of Brown University Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Justo, Aline S. Lemes, Bruna M. Nunes, Bruna Antunes, Kevin A. Capote, Anna Claudia M O Lipinski, Leandro C. Campagnoli, Eduardo B. Emiliano, Janaina Meurer, Eduardo C. Ezemma, Ogechi Miot, Helio A. [UNESP] Beltrame, Flávio L Wambier, Carlos G. |
description |
BACKGROUND: Croton oil (CO) is used by dermatologists and plastic surgeons in deep chemical peels. It is mixed with phenol, water, and a soap in Baker-Gordon's or Hetter's formulas. There is controversy as to whether CO or phenol is the active agent in the dermal effect of deep chemical peels. OBJECTIVE: To better clarify the role of CO in deep peels, by identification of active compounds in commercially available CO in the United States and biological effects in vivo. MATERIALS AND METHODS: Liquid chromatography-tandem mass spectrometry on CO and a domestic pig model experiment using 3 different formulas: G1: 5% Septisol (SEP), G2: 1.6% croton oil in 35% phenol with 5% SEP, and G3: 35% phenol with 5% SEP. RESULTS: Liquid chromatography-tandem mass spectrometry indicated the presence of phorbol esters. G1 was null overall. Extent of the coagulative necrosis: G2 > G3. Vascular ectasia: G2 > G3. Inflammation pattern: intense neutrophilic inflammatory band in G2 versus mild, sparse, perivascular mononuclear cell infiltrate in G3. Neocollagenesis: pronounced in G2, negligible in G3. CONCLUSION: Coagulative necrosis of the epidermis, superficial fibroblasts, and vasculature can be attributed to the action of phenol. Phorbol esters on CO could be responsible for the dense deep acute inflammation and the distinctive neocollagenesis. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-01 2022-04-29T08:30:42Z 2022-04-29T08:30:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1097/DSS.0000000000002990 Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], v. 47, n. 7, p. 944-946, 2021. 1524-4725 http://hdl.handle.net/11449/229142 10.1097/DSS.0000000000002990 2-s2.0-85110251582 |
url |
http://dx.doi.org/10.1097/DSS.0000000000002990 http://hdl.handle.net/11449/229142 |
identifier_str_mv |
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], v. 47, n. 7, p. 944-946, 2021. 1524-4725 10.1097/DSS.0000000000002990 2-s2.0-85110251582 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
944-946 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128192415793152 |