Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effects

Detalhes bibliográficos
Autor(a) principal: Vailati, Maria Do Carmo Fernandez [UNESP]
Data de Publicação: 2010
Outros Autores: Rocha, Noeme Souza [UNESP], Matsubara, Luiz Shiguero [UNESP], Padovani, Carlos Roberto [UNESP], Schwartz, Denise Saretta, Matsubara, Beatriz Bojikian [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/225752
Resumo: Background: The protective effect of carvedilol on multiple organ damage induced by angiotensin II (Ang II) remains unclear. The aim of this study was to evaluate the protective effect of carvedilol on the heart, liver, and kidney in rats infused with Ang II. Material/Methods: Wistar rats were randomly distributed into three groups: control (no treatment), continuously infused with Ang II (150 ηg/min for 72 hr), and treated with Ang II + carvedilol (90 mg/kg/d). Histological sections of the myocardium, kidney, and liver were analyzed for the presence of necrosis. Results: Ang II induced arterial hypertension which was not affected by carvedilol treatment (tail-cuff blood pressures, control: 125±13.6, Ang II: 163±27.3, Ang II + CV: 178±39.8 mmHg, p<0.05). Also, there were perivascular inflammation and necrosis in the myocardium, kidney, and hepatocytes necrosis around the terminal vein. Carvedilol treatment fully prevented damage to the heart and kidney and attenuated liver lesions induced by the Ang II infusion. Conclusions: The protective effect of carvedilol on perivascular damage induced by Ang II infusion depended on the target organ. The prevention of heart damage occurred independently of the antihypertensive effects of carvedilol. © Med Sci Monit, 2010.
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spelling Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effectsArteriesBeta-blockersHypertensionNecrosisBackground: The protective effect of carvedilol on multiple organ damage induced by angiotensin II (Ang II) remains unclear. The aim of this study was to evaluate the protective effect of carvedilol on the heart, liver, and kidney in rats infused with Ang II. Material/Methods: Wistar rats were randomly distributed into three groups: control (no treatment), continuously infused with Ang II (150 ηg/min for 72 hr), and treated with Ang II + carvedilol (90 mg/kg/d). Histological sections of the myocardium, kidney, and liver were analyzed for the presence of necrosis. Results: Ang II induced arterial hypertension which was not affected by carvedilol treatment (tail-cuff blood pressures, control: 125±13.6, Ang II: 163±27.3, Ang II + CV: 178±39.8 mmHg, p<0.05). Also, there were perivascular inflammation and necrosis in the myocardium, kidney, and hepatocytes necrosis around the terminal vein. Carvedilol treatment fully prevented damage to the heart and kidney and attenuated liver lesions induced by the Ang II infusion. Conclusions: The protective effect of carvedilol on perivascular damage induced by Ang II infusion depended on the target organ. The prevention of heart damage occurred independently of the antihypertensive effects of carvedilol. © Med Sci Monit, 2010.Department of Veterinary Clinic School of Veterinary Medicine São Paulo State University, Botucatu, SPDepartment of Internal Medicine School of Medicine São Paulo State University, Botucatu, SPDepartment of Biostatistics Biosciences Institute São Paulo State University, Botucatu, SPDepartment of Clinical Science School of Veterinary Medicine University of São Paulo, São Paulo, SPDepartment of Veterinary Clinic School of Veterinary Medicine São Paulo State University, Botucatu, SPDepartment of Internal Medicine School of Medicine São Paulo State University, Botucatu, SPDepartment of Biostatistics Biosciences Institute São Paulo State University, Botucatu, SPUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Vailati, Maria Do Carmo Fernandez [UNESP]Rocha, Noeme Souza [UNESP]Matsubara, Luiz Shiguero [UNESP]Padovani, Carlos Roberto [UNESP]Schwartz, Denise SarettaMatsubara, Beatriz Bojikian [UNESP]2022-04-28T20:59:30Z2022-04-28T20:59:30Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMedical Science Monitor, v. 16, n. 1, 2010.1234-10101643-3750http://hdl.handle.net/11449/2257522-s2.0-75149167883Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Science Monitorinfo:eu-repo/semantics/openAccess2024-08-14T17:23:09Zoai:repositorio.unesp.br:11449/225752Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effects
title Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effects
spellingShingle Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effects
Vailati, Maria Do Carmo Fernandez [UNESP]
Arteries
Beta-blockers
Hypertension
Necrosis
title_short Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effects
title_full Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effects
title_fullStr Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effects
title_full_unstemmed Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effects
title_sort Protective effects of carvedilol on systemic vascular damage induced by angiotensin II: Organ-specific effects independent of antihypertensive effects
author Vailati, Maria Do Carmo Fernandez [UNESP]
author_facet Vailati, Maria Do Carmo Fernandez [UNESP]
Rocha, Noeme Souza [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Padovani, Carlos Roberto [UNESP]
Schwartz, Denise Saretta
Matsubara, Beatriz Bojikian [UNESP]
author_role author
author2 Rocha, Noeme Souza [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Padovani, Carlos Roberto [UNESP]
Schwartz, Denise Saretta
Matsubara, Beatriz Bojikian [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Vailati, Maria Do Carmo Fernandez [UNESP]
Rocha, Noeme Souza [UNESP]
Matsubara, Luiz Shiguero [UNESP]
Padovani, Carlos Roberto [UNESP]
Schwartz, Denise Saretta
Matsubara, Beatriz Bojikian [UNESP]
dc.subject.por.fl_str_mv Arteries
Beta-blockers
Hypertension
Necrosis
topic Arteries
Beta-blockers
Hypertension
Necrosis
description Background: The protective effect of carvedilol on multiple organ damage induced by angiotensin II (Ang II) remains unclear. The aim of this study was to evaluate the protective effect of carvedilol on the heart, liver, and kidney in rats infused with Ang II. Material/Methods: Wistar rats were randomly distributed into three groups: control (no treatment), continuously infused with Ang II (150 ηg/min for 72 hr), and treated with Ang II + carvedilol (90 mg/kg/d). Histological sections of the myocardium, kidney, and liver were analyzed for the presence of necrosis. Results: Ang II induced arterial hypertension which was not affected by carvedilol treatment (tail-cuff blood pressures, control: 125±13.6, Ang II: 163±27.3, Ang II + CV: 178±39.8 mmHg, p<0.05). Also, there were perivascular inflammation and necrosis in the myocardium, kidney, and hepatocytes necrosis around the terminal vein. Carvedilol treatment fully prevented damage to the heart and kidney and attenuated liver lesions induced by the Ang II infusion. Conclusions: The protective effect of carvedilol on perivascular damage induced by Ang II infusion depended on the target organ. The prevention of heart damage occurred independently of the antihypertensive effects of carvedilol. © Med Sci Monit, 2010.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2022-04-28T20:59:30Z
2022-04-28T20:59:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Medical Science Monitor, v. 16, n. 1, 2010.
1234-1010
1643-3750
http://hdl.handle.net/11449/225752
2-s2.0-75149167883
identifier_str_mv Medical Science Monitor, v. 16, n. 1, 2010.
1234-1010
1643-3750
2-s2.0-75149167883
url http://hdl.handle.net/11449/225752
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical Science Monitor
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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