In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applications
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/jbm.b.34773 http://hdl.handle.net/11449/206929 |
Resumo: | Gadolinium-based contrast agents (CAs) were synthesized using faujasite zeolite (NaX) and zeolite beta (BEA) and their performances in vitro and in vivo were compared to the widely used commercial CA, gadoteric acid (Gd-DOTA). Magnetic resonance imaging (MRI) relaxometry studies (considering longitudinal [T1] and transverse [T2] relaxation times) were performed using Gd-DOTA and the zeolitic materials loaded with Gd3+. The Gd-loaded NaX, which presented large pores and cavities (7.35 and 11.24 Å, respectively), exhibited relaxivity values of around 52 mM−1 s−1, while BEA, which presented smaller pore and cavity diameters (5.95 and 6.68 Å, respectively) showed lower relaxivity values of ~4.8 mM−1 s−1. The effect of the Gd-loaded NaX as MRI CA was tested in vivo in Sprague–Dawley rats, employing a 7 T scanner, with comparison to Gd-DOTA MRI angiography. The relaxivity measurements showed that the Gd-loaded NaX (50 mM−1 s−1) provided better image contrast than Gd-DOTA (5.1 mM−1 s−1). Clearance studies of the CAs using urine and blood showed that both Gd-loaded NaX and Gd-DOTA were eliminated from the body after 2 days, demonstrating the potential of Gd-loaded NaX for use as an MRI CA. |
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In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applicationscontrast agentgadoliniumGd-DOTArelaxivityzeoliteGadolinium-based contrast agents (CAs) were synthesized using faujasite zeolite (NaX) and zeolite beta (BEA) and their performances in vitro and in vivo were compared to the widely used commercial CA, gadoteric acid (Gd-DOTA). Magnetic resonance imaging (MRI) relaxometry studies (considering longitudinal [T1] and transverse [T2] relaxation times) were performed using Gd-DOTA and the zeolitic materials loaded with Gd3+. The Gd-loaded NaX, which presented large pores and cavities (7.35 and 11.24 Å, respectively), exhibited relaxivity values of around 52 mM−1 s−1, while BEA, which presented smaller pore and cavity diameters (5.95 and 6.68 Å, respectively) showed lower relaxivity values of ~4.8 mM−1 s−1. The effect of the Gd-loaded NaX as MRI CA was tested in vivo in Sprague–Dawley rats, employing a 7 T scanner, with comparison to Gd-DOTA MRI angiography. The relaxivity measurements showed that the Gd-loaded NaX (50 mM−1 s−1) provided better image contrast than Gd-DOTA (5.1 mM−1 s−1). Clearance studies of the CAs using urine and blood showed that both Gd-loaded NaX and Gd-DOTA were eliminated from the body after 2 days, demonstrating the potential of Gd-loaded NaX for use as an MRI CA.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Departamento de Física Instituto de Biociências Letras e Ciências Exatas UNESP–Universidade Estadual PaulistaDepartment of Diagnostics and Interventional Imaging University of Texas–Health Science Center (UTHealth)Departamento de Física Instituto de Biociências Letras e Ciências Exatas UNESP–Universidade Estadual PaulistaFAPESP: #11/51851FAPESP: #19/01858-5CNPq: #406761/2013-2CNPq: #465594/2014-0CAPES: PDSE process 88881.189630/2018-01Universidade Estadual Paulista (Unesp)University of Texas–Health Science Center (UTHealth)Contro, Janine [UNESP]Silva, Danilo Antonio [UNESP]Santisteban, Oscar A. N. [UNESP]Narayana, Ponnada A.Nery, José G. [UNESP]2021-06-25T10:46:12Z2021-06-25T10:46:12Z2021-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1105-1115http://dx.doi.org/10.1002/jbm.b.34773Journal of Biomedical Materials Research - Part B Applied Biomaterials, v. 109, n. 8, p. 1105-1115, 2021.1552-49811552-4973http://hdl.handle.net/11449/20692910.1002/jbm.b.347732-s2.0-85097184249Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Biomedical Materials Research - Part B Applied Biomaterialsinfo:eu-repo/semantics/openAccess2021-10-23T15:41:41Zoai:repositorio.unesp.br:11449/206929Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:33:51.045611Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applications |
title |
In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applications |
spellingShingle |
In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applications Contro, Janine [UNESP] contrast agent gadolinium Gd-DOTA relaxivity zeolite |
title_short |
In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applications |
title_full |
In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applications |
title_fullStr |
In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applications |
title_full_unstemmed |
In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applications |
title_sort |
In vitro and in vivo comparative performance studies of gadolinium-loaded zeolites and Gd-DOTA as contrast agents for MRI applications |
author |
Contro, Janine [UNESP] |
author_facet |
Contro, Janine [UNESP] Silva, Danilo Antonio [UNESP] Santisteban, Oscar A. N. [UNESP] Narayana, Ponnada A. Nery, José G. [UNESP] |
author_role |
author |
author2 |
Silva, Danilo Antonio [UNESP] Santisteban, Oscar A. N. [UNESP] Narayana, Ponnada A. Nery, José G. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Texas–Health Science Center (UTHealth) |
dc.contributor.author.fl_str_mv |
Contro, Janine [UNESP] Silva, Danilo Antonio [UNESP] Santisteban, Oscar A. N. [UNESP] Narayana, Ponnada A. Nery, José G. [UNESP] |
dc.subject.por.fl_str_mv |
contrast agent gadolinium Gd-DOTA relaxivity zeolite |
topic |
contrast agent gadolinium Gd-DOTA relaxivity zeolite |
description |
Gadolinium-based contrast agents (CAs) were synthesized using faujasite zeolite (NaX) and zeolite beta (BEA) and their performances in vitro and in vivo were compared to the widely used commercial CA, gadoteric acid (Gd-DOTA). Magnetic resonance imaging (MRI) relaxometry studies (considering longitudinal [T1] and transverse [T2] relaxation times) were performed using Gd-DOTA and the zeolitic materials loaded with Gd3+. The Gd-loaded NaX, which presented large pores and cavities (7.35 and 11.24 Å, respectively), exhibited relaxivity values of around 52 mM−1 s−1, while BEA, which presented smaller pore and cavity diameters (5.95 and 6.68 Å, respectively) showed lower relaxivity values of ~4.8 mM−1 s−1. The effect of the Gd-loaded NaX as MRI CA was tested in vivo in Sprague–Dawley rats, employing a 7 T scanner, with comparison to Gd-DOTA MRI angiography. The relaxivity measurements showed that the Gd-loaded NaX (50 mM−1 s−1) provided better image contrast than Gd-DOTA (5.1 mM−1 s−1). Clearance studies of the CAs using urine and blood showed that both Gd-loaded NaX and Gd-DOTA were eliminated from the body after 2 days, demonstrating the potential of Gd-loaded NaX for use as an MRI CA. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:46:12Z 2021-06-25T10:46:12Z 2021-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/jbm.b.34773 Journal of Biomedical Materials Research - Part B Applied Biomaterials, v. 109, n. 8, p. 1105-1115, 2021. 1552-4981 1552-4973 http://hdl.handle.net/11449/206929 10.1002/jbm.b.34773 2-s2.0-85097184249 |
url |
http://dx.doi.org/10.1002/jbm.b.34773 http://hdl.handle.net/11449/206929 |
identifier_str_mv |
Journal of Biomedical Materials Research - Part B Applied Biomaterials, v. 109, n. 8, p. 1105-1115, 2021. 1552-4981 1552-4973 10.1002/jbm.b.34773 2-s2.0-85097184249 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Biomedical Materials Research - Part B Applied Biomaterials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1105-1115 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128228571742208 |