DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

Detalhes bibliográficos
Autor(a) principal: Moreli, Jusciele Brogin [UNESP]
Data de Publicação: 2014
Outros Autores: Santos, Janine Hertzog, Rocha, Clarissa Ribeiro, Damasceno, Debora Cristina [UNESP], Morceli, Glilciane [UNESP], Rudge, Marilza Vieira Cunha [UNESP], Bevilacqua, Estela, Calderon, Iracema de Mattos Paranhos [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2014/676758
http://hdl.handle.net/11449/117237
Resumo: The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations. These mutations can lead to and/or play a role in cancer development. This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity. While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear. DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood. Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA.
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spelling DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic EnvironmentThe increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations. These mutations can lead to and/or play a role in cancer development. This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity. While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear. DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood. Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sao Paulo State Univ, Grad Program Gynecol Obstet & Mastol, UNESP, Sao Paulo, BrazilNIEHS, Mol Carcinogenesis Lab, Durham, NC USAUniv Sao Paulo, Dept Microbiol, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, BrazilSao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynecol, UNESP, BR-18618000 Botucatu, SP, BrazilSao Paulo State Univ, Grad Program Gynecol Obstet & Mastol, UNESP, Sao Paulo, BrazilSao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynecol, UNESP, BR-18618000 Botucatu, SP, BrazilFAPESP: 11/18240-2FAPESP: 11/13562-1FAPESP: 12/23296-0Hindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)NIEHSUniversidade de São Paulo (USP)Moreli, Jusciele Brogin [UNESP]Santos, Janine HertzogRocha, Clarissa RibeiroDamasceno, Debora Cristina [UNESP]Morceli, Glilciane [UNESP]Rudge, Marilza Vieira Cunha [UNESP]Bevilacqua, EstelaCalderon, Iracema de Mattos Paranhos [UNESP]2015-03-18T15:55:37Z2015-03-18T15:55:37Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/epub+zipapplication/pdfhttp://dx.doi.org/10.1155/2014/676758Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014.2314-6133http://hdl.handle.net/11449/11723710.1155/2014/676758WOS:000340753200001WOS000340753200001.pdfWOS000340753200001.epub675868038883507806793876226047430000-0002-9227-832XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiomed Research International2.5830,935info:eu-repo/semantics/openAccess2024-01-17T06:23:27Zoai:repositorio.unesp.br:11449/117237Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-17T06:23:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
spellingShingle DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
Moreli, Jusciele Brogin [UNESP]
title_short DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title_full DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title_fullStr DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title_full_unstemmed DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title_sort DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
author Moreli, Jusciele Brogin [UNESP]
author_facet Moreli, Jusciele Brogin [UNESP]
Santos, Janine Hertzog
Rocha, Clarissa Ribeiro
Damasceno, Debora Cristina [UNESP]
Morceli, Glilciane [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Bevilacqua, Estela
Calderon, Iracema de Mattos Paranhos [UNESP]
author_role author
author2 Santos, Janine Hertzog
Rocha, Clarissa Ribeiro
Damasceno, Debora Cristina [UNESP]
Morceli, Glilciane [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Bevilacqua, Estela
Calderon, Iracema de Mattos Paranhos [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
NIEHS
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Moreli, Jusciele Brogin [UNESP]
Santos, Janine Hertzog
Rocha, Clarissa Ribeiro
Damasceno, Debora Cristina [UNESP]
Morceli, Glilciane [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Bevilacqua, Estela
Calderon, Iracema de Mattos Paranhos [UNESP]
description The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations. These mutations can lead to and/or play a role in cancer development. This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity. While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear. DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood. Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
2015-03-18T15:55:37Z
2015-03-18T15:55:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2014/676758
Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014.
2314-6133
http://hdl.handle.net/11449/117237
10.1155/2014/676758
WOS:000340753200001
WOS000340753200001.pdf
WOS000340753200001.epub
6758680388835078
0679387622604743
0000-0002-9227-832X
url http://dx.doi.org/10.1155/2014/676758
http://hdl.handle.net/11449/117237
identifier_str_mv Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014.
2314-6133
10.1155/2014/676758
WOS:000340753200001
WOS000340753200001.pdf
WOS000340753200001.epub
6758680388835078
0679387622604743
0000-0002-9227-832X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biomed Research International
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application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
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instname_str Universidade Estadual Paulista (UNESP)
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