Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.21577/0103-5053.20180045 http://hdl.handle.net/11449/179981 |
Resumo: | One new natural product, 1-phenylethyl-O-α-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two griseofulvins, three cytochalasins and one dihydroisocoumarin were produced from the endophyte Xylaria sp., both endophytic fungi are associated with leaves of Casearia sylvestris. Cyclo(D)-Pro-(D)-Phe, N-(2-phenylethyl)acetamide and 5-carboxy-6-hydroxy-3-methyl-3,4-dihydroisocoumarin exhibited potent antifungal activity against Cladosporium cladosporioides and C. sphaerospermum. The compounds cyclo(D)-Pro-(D)-Phe, griseofulvin, cytochalasin B and cytochalasin D exhibited antioxidant activity, and the compounds cyclo(D)-Pro-(D)-Phe, cytochalasin B and cytochalasin C showed potent acetylcholinesterase (AChE) inhibition. In addition, this is the first report on the isolation of secondary metabolites from two endophytic fungal strains, associated with Casearia sylvestris. Printed in Brazil- |
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Repositório Institucional da UNESP |
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2946 |
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Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activitiesBiological activityCasearia sylvestrisColletotrichum crassipesEndophytic fungiXylaria sp.One new natural product, 1-phenylethyl-O-α-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two griseofulvins, three cytochalasins and one dihydroisocoumarin were produced from the endophyte Xylaria sp., both endophytic fungi are associated with leaves of Casearia sylvestris. Cyclo(D)-Pro-(D)-Phe, N-(2-phenylethyl)acetamide and 5-carboxy-6-hydroxy-3-methyl-3,4-dihydroisocoumarin exhibited potent antifungal activity against Cladosporium cladosporioides and C. sphaerospermum. The compounds cyclo(D)-Pro-(D)-Phe, griseofulvin, cytochalasin B and cytochalasin D exhibited antioxidant activity, and the compounds cyclo(D)-Pro-(D)-Phe, cytochalasin B and cytochalasin C showed potent acetylcholinesterase (AChE) inhibition. In addition, this is the first report on the isolation of secondary metabolites from two endophytic fungal strains, associated with Casearia sylvestris. Printed in Brazil-Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Núcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Instituto de Química Universidade Estadual Paulista (Unesp)Curso de Química Ambiental Universidade Federal Do Tocantins (UFT)Laboratório de Fitoquímica e Biomoléculas (LabFitoBio) Departamento de Química Universidade Estadual de Londrina (UEL)Instituto de Ciências Exatas e Tecnológicas Universidade Federal de ViçosaSeção de Fisiologia e Bioquímica de Plantas Instituto de BotânicaDepartamento de Fitopatologia Universidade Federal de LavrasNúcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Instituto de Química Universidade Estadual Paulista (Unesp)FAPESP: 2011/03017-6Universidade Estadual Paulista (Unesp)Universidade Federal Do Tocantins (UFT)Universidade Estadual de Londrina (UEL)Universidade Federal de Viçosa (UFV)Instituto de BotânicaUniversidade Federal de Lavras (UFLA)Chapla, Vanessa M. [UNESP]Zeraik, Maria L. [UNESP]Cafeu, Mariana C. [UNESP]Silva, Geraldo H.Cavalheiro, Alberto J. [UNESP]Bolzani, Vanderlan S. [UNESP]Young, Maria C.M.Pfenning, Ludwig H.Araujo, Angela R. [UNESP]2018-12-11T17:37:32Z2018-12-11T17:37:32Z2018-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1707-1713application/pdfhttp://dx.doi.org/10.21577/0103-5053.20180045Journal of the Brazilian Chemical Society, v. 29, n. 8, p. 1707-1713, 2018.1678-47900103-5053http://hdl.handle.net/11449/17998110.21577/0103-5053.20180045S0103-505320180008017072-s2.0-85049055444S0103-50532018000801707.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society0,3570,357info:eu-repo/semantics/openAccess2024-01-23T07:09:08Zoai:repositorio.unesp.br:11449/179981Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-23T07:09:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities |
title |
Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities |
spellingShingle |
Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities Chapla, Vanessa M. [UNESP] Biological activity Casearia sylvestris Colletotrichum crassipes Endophytic fungi Xylaria sp. |
title_short |
Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities |
title_full |
Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities |
title_fullStr |
Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities |
title_full_unstemmed |
Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities |
title_sort |
Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities |
author |
Chapla, Vanessa M. [UNESP] |
author_facet |
Chapla, Vanessa M. [UNESP] Zeraik, Maria L. [UNESP] Cafeu, Mariana C. [UNESP] Silva, Geraldo H. Cavalheiro, Alberto J. [UNESP] Bolzani, Vanderlan S. [UNESP] Young, Maria C.M. Pfenning, Ludwig H. Araujo, Angela R. [UNESP] |
author_role |
author |
author2 |
Zeraik, Maria L. [UNESP] Cafeu, Mariana C. [UNESP] Silva, Geraldo H. Cavalheiro, Alberto J. [UNESP] Bolzani, Vanderlan S. [UNESP] Young, Maria C.M. Pfenning, Ludwig H. Araujo, Angela R. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal Do Tocantins (UFT) Universidade Estadual de Londrina (UEL) Universidade Federal de Viçosa (UFV) Instituto de Botânica Universidade Federal de Lavras (UFLA) |
dc.contributor.author.fl_str_mv |
Chapla, Vanessa M. [UNESP] Zeraik, Maria L. [UNESP] Cafeu, Mariana C. [UNESP] Silva, Geraldo H. Cavalheiro, Alberto J. [UNESP] Bolzani, Vanderlan S. [UNESP] Young, Maria C.M. Pfenning, Ludwig H. Araujo, Angela R. [UNESP] |
dc.subject.por.fl_str_mv |
Biological activity Casearia sylvestris Colletotrichum crassipes Endophytic fungi Xylaria sp. |
topic |
Biological activity Casearia sylvestris Colletotrichum crassipes Endophytic fungi Xylaria sp. |
description |
One new natural product, 1-phenylethyl-O-α-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two griseofulvins, three cytochalasins and one dihydroisocoumarin were produced from the endophyte Xylaria sp., both endophytic fungi are associated with leaves of Casearia sylvestris. Cyclo(D)-Pro-(D)-Phe, N-(2-phenylethyl)acetamide and 5-carboxy-6-hydroxy-3-methyl-3,4-dihydroisocoumarin exhibited potent antifungal activity against Cladosporium cladosporioides and C. sphaerospermum. The compounds cyclo(D)-Pro-(D)-Phe, griseofulvin, cytochalasin B and cytochalasin D exhibited antioxidant activity, and the compounds cyclo(D)-Pro-(D)-Phe, cytochalasin B and cytochalasin C showed potent acetylcholinesterase (AChE) inhibition. In addition, this is the first report on the isolation of secondary metabolites from two endophytic fungal strains, associated with Casearia sylvestris. Printed in Brazil- |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:37:32Z 2018-12-11T17:37:32Z 2018-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.21577/0103-5053.20180045 Journal of the Brazilian Chemical Society, v. 29, n. 8, p. 1707-1713, 2018. 1678-4790 0103-5053 http://hdl.handle.net/11449/179981 10.21577/0103-5053.20180045 S0103-50532018000801707 2-s2.0-85049055444 S0103-50532018000801707.pdf |
url |
http://dx.doi.org/10.21577/0103-5053.20180045 http://hdl.handle.net/11449/179981 |
identifier_str_mv |
Journal of the Brazilian Chemical Society, v. 29, n. 8, p. 1707-1713, 2018. 1678-4790 0103-5053 10.21577/0103-5053.20180045 S0103-50532018000801707 2-s2.0-85049055444 S0103-50532018000801707.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society 0,357 0,357 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1707-1713 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965705079095296 |