Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/225180 |
Resumo: | Dopamine (DA) is known as a primary regulator of prolactin secretion (PRL) and angiotensin II (Ang II) has been recognized as one brain inhibitory factor of this secretion. In this work, estrogen-primed or unprimed ovariectomized rats were submitted to the microinjection of saline or Ang II after previous microinjection of saline or of DA antagonist (haloperidol, sulpiride or SCH) both in the medial preoptic area (MPOA). Our study of these interactions has shown that 1) estrogen-induced PRL secretion is mediated by Ang II and DA actions in the MPOA, i.e. very high plasma PRL would be prevented by inhibitory action of Ang II, while very low levels would be prevented in part by stimulatory action of DA through D2 receptors, 2) the inhibitory action of Ang II depends on estrogen and is mediated in part by inhibitory action of DA through D1 receptors and in other part by inhibition of stimulatory action of DA through D2 receptors. © 2008 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic. |
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Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretionAngiotensin IIDopaminergic antagonistsEstrogenMedial preoptic areaProlactinDopamine (DA) is known as a primary regulator of prolactin secretion (PRL) and angiotensin II (Ang II) has been recognized as one brain inhibitory factor of this secretion. In this work, estrogen-primed or unprimed ovariectomized rats were submitted to the microinjection of saline or Ang II after previous microinjection of saline or of DA antagonist (haloperidol, sulpiride or SCH) both in the medial preoptic area (MPOA). Our study of these interactions has shown that 1) estrogen-induced PRL secretion is mediated by Ang II and DA actions in the MPOA, i.e. very high plasma PRL would be prevented by inhibitory action of Ang II, while very low levels would be prevented in part by stimulatory action of DA through D2 receptors, 2) the inhibitory action of Ang II depends on estrogen and is mediated in part by inhibitory action of DA through D1 receptors and in other part by inhibition of stimulatory action of DA through D2 receptors. © 2008 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic.Department of Basic Science Faculty of Odontology University of Estadual Paulista, AraçatubaDepartment of Physiology Faculty of Medicine of Ribeirão Preto University of São Paulo, Av. Bandeirantes, Ribeirão PretoDepartamento de Fisiologia Faculdade de Medicina de Ribeirão Preto Campus USP, Av. Bandeirantes, 3900, 14049-900, Ribeirão Preto, SPDepartment of Basic Science Faculty of Odontology University of Estadual Paulista, AraçatubaUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Leite, C. M.Machado, G. J.R. [UNESP]Dornelles, R. C.M. [UNESP]Franci, Celso Rodrigues2022-04-28T20:41:58Z2022-04-28T20:41:58Z2008-06-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article109-118Physiological Research, v. 57, n. 1, p. 109-118, 2008.0862-8408http://hdl.handle.net/11449/2251802-s2.0-45349090863Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiological Researchinfo:eu-repo/semantics/openAccess2022-04-28T20:41:58Zoai:repositorio.unesp.br:11449/225180Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:29:51.550993Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
spellingShingle |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion Leite, C. M. Angiotensin II Dopaminergic antagonists Estrogen Medial preoptic area Prolactin |
title_short |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title_full |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title_fullStr |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title_full_unstemmed |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title_sort |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
author |
Leite, C. M. |
author_facet |
Leite, C. M. Machado, G. J.R. [UNESP] Dornelles, R. C.M. [UNESP] Franci, Celso Rodrigues |
author_role |
author |
author2 |
Machado, G. J.R. [UNESP] Dornelles, R. C.M. [UNESP] Franci, Celso Rodrigues |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Leite, C. M. Machado, G. J.R. [UNESP] Dornelles, R. C.M. [UNESP] Franci, Celso Rodrigues |
dc.subject.por.fl_str_mv |
Angiotensin II Dopaminergic antagonists Estrogen Medial preoptic area Prolactin |
topic |
Angiotensin II Dopaminergic antagonists Estrogen Medial preoptic area Prolactin |
description |
Dopamine (DA) is known as a primary regulator of prolactin secretion (PRL) and angiotensin II (Ang II) has been recognized as one brain inhibitory factor of this secretion. In this work, estrogen-primed or unprimed ovariectomized rats were submitted to the microinjection of saline or Ang II after previous microinjection of saline or of DA antagonist (haloperidol, sulpiride or SCH) both in the medial preoptic area (MPOA). Our study of these interactions has shown that 1) estrogen-induced PRL secretion is mediated by Ang II and DA actions in the MPOA, i.e. very high plasma PRL would be prevented by inhibitory action of Ang II, while very low levels would be prevented in part by stimulatory action of DA through D2 receptors, 2) the inhibitory action of Ang II depends on estrogen and is mediated in part by inhibitory action of DA through D1 receptors and in other part by inhibition of stimulatory action of DA through D2 receptors. © 2008 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06-24 2022-04-28T20:41:58Z 2022-04-28T20:41:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Physiological Research, v. 57, n. 1, p. 109-118, 2008. 0862-8408 http://hdl.handle.net/11449/225180 2-s2.0-45349090863 |
identifier_str_mv |
Physiological Research, v. 57, n. 1, p. 109-118, 2008. 0862-8408 2-s2.0-45349090863 |
url |
http://hdl.handle.net/11449/225180 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physiological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
109-118 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129525730508800 |