Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bbr.2013.05.064 http://hdl.handle.net/11449/219919 |
Resumo: | Fluoxetine (FLX) is commonly used to treat anxiety and depressive disorders in pregnant women. Since FLX crosses the placenta and is excreted in milk, maternal treatment with this antidepressant may expose the fetus and neonate to increased levels of serotonin (5-HT). Long-term behavioral abnormalities have been reported in rodents exposed to higher levels of 5-HT during neurodevelopment. In this study we evaluated if maternal exposure to FLX during pregnancy and lactation would result in behavioral and/or stress response disruption in adolescent and adult rats. Our results indicate that exposure to FLX influenced restraint stress-induced Fos expression in the amygdala in a gender and age-specific manner. In male animals, a decreased expression was observed in the basolateral amygdala at adolescence and adulthood; whereas at adulthood, a decrease was also observed in the medial amygdala. A lack of FLX exposure effect was observed in females and also in the paraventricular nucleus of both genders. Regarding the behavioral evaluation, FLX exposure did not induce anhedonia in the sucrose preference test but decreased the latency to feed of both male and female adolescent rats evaluated in the novelty-suppressed feeding test. In conclusion, FLX exposure during pregnancy and lactation decreases acute amygdalar stress response to a psychological stressor in males (adolescents and adults) as well as influences the behavior of adolescents (males and females) in a model that evaluates anxiety and/or depressive-like behavior. Even though FLX seems to be a developmental neurotoxicant, the translation of these findings to human safe assessment remains to be determined since it is recognized that not treating a pregnant or lactating woman may also impact negatively the development of the descendants. © 2013 Elsevier B.V. |
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Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in ratsAntidepressantsBehaviorFluoxetineFosNeurodevelopmentStressFluoxetine (FLX) is commonly used to treat anxiety and depressive disorders in pregnant women. Since FLX crosses the placenta and is excreted in milk, maternal treatment with this antidepressant may expose the fetus and neonate to increased levels of serotonin (5-HT). Long-term behavioral abnormalities have been reported in rodents exposed to higher levels of 5-HT during neurodevelopment. In this study we evaluated if maternal exposure to FLX during pregnancy and lactation would result in behavioral and/or stress response disruption in adolescent and adult rats. Our results indicate that exposure to FLX influenced restraint stress-induced Fos expression in the amygdala in a gender and age-specific manner. In male animals, a decreased expression was observed in the basolateral amygdala at adolescence and adulthood; whereas at adulthood, a decrease was also observed in the medial amygdala. A lack of FLX exposure effect was observed in females and also in the paraventricular nucleus of both genders. Regarding the behavioral evaluation, FLX exposure did not induce anhedonia in the sucrose preference test but decreased the latency to feed of both male and female adolescent rats evaluated in the novelty-suppressed feeding test. In conclusion, FLX exposure during pregnancy and lactation decreases acute amygdalar stress response to a psychological stressor in males (adolescents and adults) as well as influences the behavior of adolescents (males and females) in a model that evaluates anxiety and/or depressive-like behavior. Even though FLX seems to be a developmental neurotoxicant, the translation of these findings to human safe assessment remains to be determined since it is recognized that not treating a pregnant or lactating woman may also impact negatively the development of the descendants. © 2013 Elsevier B.V.Departamento de Ciências Fisiológicas Universidade Estadual de Londrina, PRCentro de Pesquisa em Ciências da Saúde Universidade Norte do Paraná, PRDepartamento de Fisiologia e Biofísica Instituto de Ciências Biomédicas Universidade Estadual de São Paulo, SPDepartamento de Fisiologia e Biofísica Instituto de Ciências Biomédicas Universidade Estadual de São Paulo, SPUniversidade Estadual de Londrina (UEL)Universidade Norte do ParanáUniversidade Estadual Paulista (UNESP)Francis-Oliveira, JoséPonte, BiancaBarbosa, Ana Paula MorenoVeríssimo, Luiz FernandoGomes, Marcus ViníciusPelosi, Gislaine Garciade Britto, Luiz Roberto Giorgetti [UNESP]Moreira, Estefânia Gastaldello2022-04-28T18:58:29Z2022-04-28T18:58:29Z2013-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article195-203http://dx.doi.org/10.1016/j.bbr.2013.05.064Behavioural Brain Research, v. 252, p. 195-203.0166-43281872-7549http://hdl.handle.net/11449/21991910.1016/j.bbr.2013.05.0642-s2.0-84879708180Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBehavioural Brain Researchinfo:eu-repo/semantics/openAccess2022-04-28T18:58:29Zoai:repositorio.unesp.br:11449/219919Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:38:09.347704Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats |
title |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats |
spellingShingle |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats Francis-Oliveira, José Antidepressants Behavior Fluoxetine Fos Neurodevelopment Stress |
title_short |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats |
title_full |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats |
title_fullStr |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats |
title_full_unstemmed |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats |
title_sort |
Fluoxetine exposure during pregnancy and lactation: Effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats |
author |
Francis-Oliveira, José |
author_facet |
Francis-Oliveira, José Ponte, Bianca Barbosa, Ana Paula Moreno Veríssimo, Luiz Fernando Gomes, Marcus Vinícius Pelosi, Gislaine Garcia de Britto, Luiz Roberto Giorgetti [UNESP] Moreira, Estefânia Gastaldello |
author_role |
author |
author2 |
Ponte, Bianca Barbosa, Ana Paula Moreno Veríssimo, Luiz Fernando Gomes, Marcus Vinícius Pelosi, Gislaine Garcia de Britto, Luiz Roberto Giorgetti [UNESP] Moreira, Estefânia Gastaldello |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Londrina (UEL) Universidade Norte do Paraná Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Francis-Oliveira, José Ponte, Bianca Barbosa, Ana Paula Moreno Veríssimo, Luiz Fernando Gomes, Marcus Vinícius Pelosi, Gislaine Garcia de Britto, Luiz Roberto Giorgetti [UNESP] Moreira, Estefânia Gastaldello |
dc.subject.por.fl_str_mv |
Antidepressants Behavior Fluoxetine Fos Neurodevelopment Stress |
topic |
Antidepressants Behavior Fluoxetine Fos Neurodevelopment Stress |
description |
Fluoxetine (FLX) is commonly used to treat anxiety and depressive disorders in pregnant women. Since FLX crosses the placenta and is excreted in milk, maternal treatment with this antidepressant may expose the fetus and neonate to increased levels of serotonin (5-HT). Long-term behavioral abnormalities have been reported in rodents exposed to higher levels of 5-HT during neurodevelopment. In this study we evaluated if maternal exposure to FLX during pregnancy and lactation would result in behavioral and/or stress response disruption in adolescent and adult rats. Our results indicate that exposure to FLX influenced restraint stress-induced Fos expression in the amygdala in a gender and age-specific manner. In male animals, a decreased expression was observed in the basolateral amygdala at adolescence and adulthood; whereas at adulthood, a decrease was also observed in the medial amygdala. A lack of FLX exposure effect was observed in females and also in the paraventricular nucleus of both genders. Regarding the behavioral evaluation, FLX exposure did not induce anhedonia in the sucrose preference test but decreased the latency to feed of both male and female adolescent rats evaluated in the novelty-suppressed feeding test. In conclusion, FLX exposure during pregnancy and lactation decreases acute amygdalar stress response to a psychological stressor in males (adolescents and adults) as well as influences the behavior of adolescents (males and females) in a model that evaluates anxiety and/or depressive-like behavior. Even though FLX seems to be a developmental neurotoxicant, the translation of these findings to human safe assessment remains to be determined since it is recognized that not treating a pregnant or lactating woman may also impact negatively the development of the descendants. © 2013 Elsevier B.V. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-01 2022-04-28T18:58:29Z 2022-04-28T18:58:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bbr.2013.05.064 Behavioural Brain Research, v. 252, p. 195-203. 0166-4328 1872-7549 http://hdl.handle.net/11449/219919 10.1016/j.bbr.2013.05.064 2-s2.0-84879708180 |
url |
http://dx.doi.org/10.1016/j.bbr.2013.05.064 http://hdl.handle.net/11449/219919 |
identifier_str_mv |
Behavioural Brain Research, v. 252, p. 195-203. 0166-4328 1872-7549 10.1016/j.bbr.2013.05.064 2-s2.0-84879708180 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Behavioural Brain Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
195-203 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128956917874688 |