The influence of hubs in the structure of a neuronal network during an epileptic seizure

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Abner Cardoso
Data de Publicação: 2016
Outros Autores: Cerdeira, Hilda A. [UNESP], Machado, Birajara Soares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1140/epjst/e2016-02626-7
http://hdl.handle.net/11449/161266
Resumo: In this work, we propose changes in the structure of a neuronal network with the intention to provoke strong synchronization to simulate episodes of epileptic seizure. Starting with a network of Izhikevich neurons we slowly increase the number of connections in selected nodes in a controlled way, to produce (or not) hubs. We study how these structures alter the synchronization on the spike firings interval, on individual neurons as well as on mean values, as a function of the concentration of connections for random and non-random (hubs) distribution. We also analyze how the post-ictal signal varies for the different distributions. We conclude that a network with hubs is more appropriate to represent an epileptic state.
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spelling The influence of hubs in the structure of a neuronal network during an epileptic seizureIn this work, we propose changes in the structure of a neuronal network with the intention to provoke strong synchronization to simulate episodes of epileptic seizure. Starting with a network of Izhikevich neurons we slowly increase the number of connections in selected nodes in a controlled way, to produce (or not) hubs. We study how these structures alter the synchronization on the spike firings interval, on individual neurons as well as on mean values, as a function of the concentration of connections for random and non-random (hubs) distribution. We also analyze how the post-ictal signal varies for the different distributions. We conclude that a network with hubs is more appropriate to represent an epileptic state.UNIEMPFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Sao Paulo, Bioinformat Interunits Grad Program, Sao Paulo, BrazilUniv Estadual Paulista, Inst Fis Teor, Rua Pamplona 145, BR-01405 Sao Paulo, BrazilHosp Israelita Albert Einstein, Sao Paulo, BrazilUniv Estadual Paulista, Inst Fis Teor, Rua Pamplona 145, BR-01405 Sao Paulo, BrazilFAPESP: 2011/11973-4SpringerUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Hosp Israelita Albert EinsteinRodrigues, Abner CardosoCerdeira, Hilda A. [UNESP]Machado, Birajara Soares2018-11-26T16:27:49Z2018-11-26T16:27:49Z2016-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article75-82application/pdfhttp://dx.doi.org/10.1140/epjst/e2016-02626-7European Physical Journal-special Topics. Heidelberg: Springer Heidelberg, v. 225, n. 1, p. 75-82, 2016.1951-6355http://hdl.handle.net/11449/16126610.1140/epjst/e2016-02626-7WOS:000371423700008WOS000371423700008.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Physical Journal-special Topics0,552info:eu-repo/semantics/openAccess2024-01-14T06:17:40Zoai:repositorio.unesp.br:11449/161266Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:54:44.206748Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The influence of hubs in the structure of a neuronal network during an epileptic seizure
title The influence of hubs in the structure of a neuronal network during an epileptic seizure
spellingShingle The influence of hubs in the structure of a neuronal network during an epileptic seizure
Rodrigues, Abner Cardoso
title_short The influence of hubs in the structure of a neuronal network during an epileptic seizure
title_full The influence of hubs in the structure of a neuronal network during an epileptic seizure
title_fullStr The influence of hubs in the structure of a neuronal network during an epileptic seizure
title_full_unstemmed The influence of hubs in the structure of a neuronal network during an epileptic seizure
title_sort The influence of hubs in the structure of a neuronal network during an epileptic seizure
author Rodrigues, Abner Cardoso
author_facet Rodrigues, Abner Cardoso
Cerdeira, Hilda A. [UNESP]
Machado, Birajara Soares
author_role author
author2 Cerdeira, Hilda A. [UNESP]
Machado, Birajara Soares
author2_role author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
Hosp Israelita Albert Einstein
dc.contributor.author.fl_str_mv Rodrigues, Abner Cardoso
Cerdeira, Hilda A. [UNESP]
Machado, Birajara Soares
description In this work, we propose changes in the structure of a neuronal network with the intention to provoke strong synchronization to simulate episodes of epileptic seizure. Starting with a network of Izhikevich neurons we slowly increase the number of connections in selected nodes in a controlled way, to produce (or not) hubs. We study how these structures alter the synchronization on the spike firings interval, on individual neurons as well as on mean values, as a function of the concentration of connections for random and non-random (hubs) distribution. We also analyze how the post-ictal signal varies for the different distributions. We conclude that a network with hubs is more appropriate to represent an epileptic state.
publishDate 2016
dc.date.none.fl_str_mv 2016-02-01
2018-11-26T16:27:49Z
2018-11-26T16:27:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1140/epjst/e2016-02626-7
European Physical Journal-special Topics. Heidelberg: Springer Heidelberg, v. 225, n. 1, p. 75-82, 2016.
1951-6355
http://hdl.handle.net/11449/161266
10.1140/epjst/e2016-02626-7
WOS:000371423700008
WOS000371423700008.pdf
url http://dx.doi.org/10.1140/epjst/e2016-02626-7
http://hdl.handle.net/11449/161266
identifier_str_mv European Physical Journal-special Topics. Heidelberg: Springer Heidelberg, v. 225, n. 1, p. 75-82, 2016.
1951-6355
10.1140/epjst/e2016-02626-7
WOS:000371423700008
WOS000371423700008.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv European Physical Journal-special Topics
0,552
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 75-82
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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