Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians

• Autor(a) principal: Delfino-Pereira, Polianna
• Data de Publicação: 2023
• Outros Autores: Pires, Magda Carvalho, Gomes, Virginia Mara Reis, Nogueira, Matheus Carvalho Alves, Lima, Maria Clara Pontello Barbosa, Schwarzbold, Alexandre Vargas, Maurílio, Amanda de Oliveira, Scotton, Ana Luiza Bahia Alves, Costa, André Soares de Moura, Farace, Barbara Lopes, de Castro, Bruno Mateus, Cimini, Christiane Corrêa Rodrigues, Silveira, Daniel Vitório, Ponce, Daniela [UNESP], Pereira, Elayne Crestani, Roesch, Eliane Würdig, Manenti, Euler Roberto Fernandes, Cenci, Evelin Paola de Almeida, dos Santos, Fernanda Costa, Anschau, Fernando, Aranha, Fernando Graça, Bartolazzi, Frederico, Nascimento, Guilherme Fagundes, Vianna, Heloisa Reniers, d'Arc Lyra Batista, Joanna, de Alvarenga, Joice Coutinho, Carvalho, Juliana da Silva Nogueira, Machado-Rugolo, Juliana [UNESP], Ruschel, Karen Brasil, Menezes, Luanna Silva Monteiro, de Castro, Luís César, Nasi, Luiz Antônio, Floriani, Maiara Anschau, Souza, Maíra Dias, Souza-Silva, Maíra Viana Rego, Carneiro, Marcelo, Bicalho, Maria Aparecida Camargos, de Godoy, Mariana Frizzo, Guimarães-Júnior, Milton Henriques, Ziegelmann, Patricia Klarmann, Assaf, Pedro Ledic, Martelli, Petrônio José de Lima, Finger, Renan Goulart, Francisco, Saionara Cristina, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, de Oliveira, Thainara Conceição, Lage, Thalita Martins, Muller, Vanessa, Ramires, Yuri Carlotto, Ferrari, Teresa Cristina de Abreu, Marcolino, Milena Soriano
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.ijid.2023.02.012; http://hdl.handle.net/11449/246975
• topic: Clinical characteristics; COVID-19; Hospital-manifested infection; In-hospital mortality; Outcomes; Risk factors

Objectives: To analyze the clinical characteristics and outcomes of admitted patients with the hospital- versus community-manifested COVID-19 and to evaluate the risk factors related to mortality in the first population. Methods: This retrospective cohort included consecutive adult patients with COVID-19, hospitalized between March and September 2020. The demographic data, clinical characteristics, and outcomes were extracted from medical records. Patients with hospital-manifested COVID-19 (study group) and those with community-manifested COVID-19 (control group) were matched by the propensity score model. Logistic regression models were used to verify the risk factors for mortality in the study group. Results: Among 7,710 hospitalized patients who had COVID-19, 7.2% developed symptoms while admitted for other reasons. Patients with hospital-manifested COVID-19 had a higher prevalence of cancer (19.2% vs 10.8%) and alcoholism (8.8% vs 2.8%) than patients with community-manifested COVID-19 and also had a higher rate of intensive care unit requirement (45.1% vs 35.2%), sepsis (23.8% vs 14.5%), and death (35.8% vs 22.5%) (P <0.05 for all). The factors independently associated with increased mortality in the study group were increasing age, male sex, number of comorbidities, and cancer. Conclusion: Hospital-manifested COVID-19 was associated with increased mortality. Increasing age, male sex, number of comorbidities, and cancer were independent predictors of mortality among those with hospital-manifested COVID-19 disease.