Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing disease
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1093/ecco-jcc/jjv228 http://hdl.handle.net/11449/168629 |
Resumo: | The fifth scientific workshop of the European Crohn's and Colitis Organization (ECCO) focused on the relevance of fistulas to the disease course of patients with Crohn's disease (CD). The objectives were to reach a better understanding of the pathophysiological mechanisms underlying the formation of CD fistulas; to identify future topics in fistula research that could provide insights into pathogenesis; to develop novel therapeutic approaches; and to review current therapeutic strategies (with clarification of existing approaches to prevention, diagnosis and treatment). The results of the workshop are presented in two separate manuscripts. This manuscript describes current state-of-the-art knowledge about fistula pathogenesis, including the roles of epithelial-tomesenchymal transition and cytokine matrix remodelling enzymes, and highlights the common association between fistulas and stenosis in CD. The review also considers the possible roles that genetic predisposition and intestinal microbiota play in fistula development. Finally, it proposes future directions and needs for fistula research that might substantially increase our understanding of this complex condition and help unravel novel therapeutic strategies and specific targets for treatment. Overall, it aims to highlight unanswered questions in fistula research and to provide a framework for future research work. |
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Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing diseaseCrohn's diseaseCytokinesEpithelial-to-mesenchymal transitionFibrosisFistulaGenetic predispositionInflammatory bowel diseaseIntestinal microbiotaMouse modelsThe fifth scientific workshop of the European Crohn's and Colitis Organization (ECCO) focused on the relevance of fistulas to the disease course of patients with Crohn's disease (CD). The objectives were to reach a better understanding of the pathophysiological mechanisms underlying the formation of CD fistulas; to identify future topics in fistula research that could provide insights into pathogenesis; to develop novel therapeutic approaches; and to review current therapeutic strategies (with clarification of existing approaches to prevention, diagnosis and treatment). The results of the workshop are presented in two separate manuscripts. This manuscript describes current state-of-the-art knowledge about fistula pathogenesis, including the roles of epithelial-tomesenchymal transition and cytokine matrix remodelling enzymes, and highlights the common association between fistulas and stenosis in CD. The review also considers the possible roles that genetic predisposition and intestinal microbiota play in fistula development. Finally, it proposes future directions and needs for fistula research that might substantially increase our understanding of this complex condition and help unravel novel therapeutic strategies and specific targets for treatment. Overall, it aims to highlight unanswered questions in fistula research and to provide a framework for future research work.Department of Medicine (Gastroenterology Infectious Diseases Rheumatology) Charité-Universitätsmedizin BerlinDepartment of Histopathology Royal London HospitalAcademic Department of Gastroenterology Ethnikon and Kapodistriakon University of Athens Laikon HospitalESADI Clinic and Gastroenterology Unit Santa Isabel HospitalColorectal Unit Gastrosaude ClinicDepartment of Surgery UNESP BotucatuDivision of Gastroenterology and Hepatology University Hospital Zurich University of ZurichDepartment of Surgery UNESP BotucatuCharité-Universitätsmedizin BerlinRoyal London HospitalLaikon HospitalSanta Isabel HospitalGastrosaude ClinicUniversidade Estadual Paulista (Unesp)University of ZurichSiegmund, BrittaFeakins, Roger M.Bamias, GiorgosLudvig, Juliano CoelhoTeixeira, Fabio Vieira [UNESP]Rogler, GerhardScharl, Michael2018-12-11T16:42:16Z2018-12-11T16:42:16Z2016-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article377-386application/pdfhttp://dx.doi.org/10.1093/ecco-jcc/jjv228Journal of Crohn's and Colitis, v. 10, n. 4, p. 377-386, 2016.1876-44791873-9946http://hdl.handle.net/11449/16862910.1093/ecco-jcc/jjv2282-s2.0-849662674112-s2.0-84966267411.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Crohn's and Colitis2,728info:eu-repo/semantics/openAccess2023-11-19T06:12:38Zoai:repositorio.unesp.br:11449/168629Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:08:31.902226Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing disease |
title |
Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing disease |
spellingShingle |
Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing disease Siegmund, Britta Crohn's disease Cytokines Epithelial-to-mesenchymal transition Fibrosis Fistula Genetic predisposition Inflammatory bowel disease Intestinal microbiota Mouse models |
title_short |
Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing disease |
title_full |
Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing disease |
title_fullStr |
Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing disease |
title_full_unstemmed |
Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing disease |
title_sort |
Results of the fifth scientific workshop of the ECCO (II): Pathophysiology of perianal fistulizing disease |
author |
Siegmund, Britta |
author_facet |
Siegmund, Britta Feakins, Roger M. Bamias, Giorgos Ludvig, Juliano Coelho Teixeira, Fabio Vieira [UNESP] Rogler, Gerhard Scharl, Michael |
author_role |
author |
author2 |
Feakins, Roger M. Bamias, Giorgos Ludvig, Juliano Coelho Teixeira, Fabio Vieira [UNESP] Rogler, Gerhard Scharl, Michael |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Charité-Universitätsmedizin Berlin Royal London Hospital Laikon Hospital Santa Isabel Hospital Gastrosaude Clinic Universidade Estadual Paulista (Unesp) University of Zurich |
dc.contributor.author.fl_str_mv |
Siegmund, Britta Feakins, Roger M. Bamias, Giorgos Ludvig, Juliano Coelho Teixeira, Fabio Vieira [UNESP] Rogler, Gerhard Scharl, Michael |
dc.subject.por.fl_str_mv |
Crohn's disease Cytokines Epithelial-to-mesenchymal transition Fibrosis Fistula Genetic predisposition Inflammatory bowel disease Intestinal microbiota Mouse models |
topic |
Crohn's disease Cytokines Epithelial-to-mesenchymal transition Fibrosis Fistula Genetic predisposition Inflammatory bowel disease Intestinal microbiota Mouse models |
description |
The fifth scientific workshop of the European Crohn's and Colitis Organization (ECCO) focused on the relevance of fistulas to the disease course of patients with Crohn's disease (CD). The objectives were to reach a better understanding of the pathophysiological mechanisms underlying the formation of CD fistulas; to identify future topics in fistula research that could provide insights into pathogenesis; to develop novel therapeutic approaches; and to review current therapeutic strategies (with clarification of existing approaches to prevention, diagnosis and treatment). The results of the workshop are presented in two separate manuscripts. This manuscript describes current state-of-the-art knowledge about fistula pathogenesis, including the roles of epithelial-tomesenchymal transition and cytokine matrix remodelling enzymes, and highlights the common association between fistulas and stenosis in CD. The review also considers the possible roles that genetic predisposition and intestinal microbiota play in fistula development. Finally, it proposes future directions and needs for fistula research that might substantially increase our understanding of this complex condition and help unravel novel therapeutic strategies and specific targets for treatment. Overall, it aims to highlight unanswered questions in fistula research and to provide a framework for future research work. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04-01 2018-12-11T16:42:16Z 2018-12-11T16:42:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1093/ecco-jcc/jjv228 Journal of Crohn's and Colitis, v. 10, n. 4, p. 377-386, 2016. 1876-4479 1873-9946 http://hdl.handle.net/11449/168629 10.1093/ecco-jcc/jjv228 2-s2.0-84966267411 2-s2.0-84966267411.pdf |
url |
http://dx.doi.org/10.1093/ecco-jcc/jjv228 http://hdl.handle.net/11449/168629 |
identifier_str_mv |
Journal of Crohn's and Colitis, v. 10, n. 4, p. 377-386, 2016. 1876-4479 1873-9946 10.1093/ecco-jcc/jjv228 2-s2.0-84966267411 2-s2.0-84966267411.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Crohn's and Colitis 2,728 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
377-386 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128900937547776 |