Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ

Detalhes bibliográficos
Autor(a) principal: Lima, Thania Rios Rossi [UNESP]
Data de Publicação: 2021
Outros Autores: Sales, Bianca Camargo Penteado [UNESP], Catalano, Shadia Muhammad Ihlaseh
Tipo de documento: Capítulo de livro
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/978-1-0716-1091-6_8
http://hdl.handle.net/11449/207165
Resumo: The urinary bladder is a target organ of several toxic agents. Exposure to those agents induces mild-to-severe changes, which can be evaluated by different methods. Among them, the scanning-electron microscopy (SEM) is the “gold standard” for characterizing urothelial damage since it provides high-definition images, making it possible to detect early lesions on the surface of the urinary bladder. In addition, molecular technologies allow detecting changes in genetic material and investigating the interaction between genes and environmental stress in disease causation. The urinary bladder epithelium is where the most common type of bladder cancer occurs in humans, that is, the transitional-cell carcinoma (TCC). In animal models, the TCC can be similar to the disease in humans. Techniques to evaluate urothelium in experimental models aid in the comprehension of risk factors for urothelial carcinogenesis.
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spelling Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target OrganCytotoxicityEpithelial cellsIn vivoMolecular biologyScanning-electron microscopyUrinary bladderThe urinary bladder is a target organ of several toxic agents. Exposure to those agents induces mild-to-severe changes, which can be evaluated by different methods. Among them, the scanning-electron microscopy (SEM) is the “gold standard” for characterizing urothelial damage since it provides high-definition images, making it possible to detect early lesions on the surface of the urinary bladder. In addition, molecular technologies allow detecting changes in genetic material and investigating the interaction between genes and environmental stress in disease causation. The urinary bladder epithelium is where the most common type of bladder cancer occurs in humans, that is, the transitional-cell carcinoma (TCC). In animal models, the TCC can be similar to the disease in humans. Techniques to evaluate urothelium in experimental models aid in the comprehension of risk factors for urothelial carcinogenesis.Department of Pathology Botucatu Medical School Center for the Evaluation of the Environmental Impact on Human Health (TOXICAM) São Paulo State University (UNESP)Regulatory Toxicology and Risk Corteva AgriscienceDepartment of Pathology Botucatu Medical School Center for the Evaluation of the Environmental Impact on Human Health (TOXICAM) São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Corteva AgriscienceLima, Thania Rios Rossi [UNESP]Sales, Bianca Camargo Penteado [UNESP]Catalano, Shadia Muhammad Ihlaseh2021-06-25T10:49:57Z2021-06-25T10:49:57Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart93-102http://dx.doi.org/10.1007/978-1-0716-1091-6_8Methods in Molecular Biology, v. 2240, p. 93-102.1940-60291064-3745http://hdl.handle.net/11449/20716510.1007/978-1-0716-1091-6_82-s2.0-85099690919Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMethods in Molecular Biologyinfo:eu-repo/semantics/openAccess2024-09-03T13:18:45Zoai:repositorio.unesp.br:11449/207165Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ
title Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ
spellingShingle Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ
Lima, Thania Rios Rossi [UNESP]
Cytotoxicity
Epithelial cells
In vivo
Molecular biology
Scanning-electron microscopy
Urinary bladder
title_short Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ
title_full Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ
title_fullStr Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ
title_full_unstemmed Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ
title_sort Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ
author Lima, Thania Rios Rossi [UNESP]
author_facet Lima, Thania Rios Rossi [UNESP]
Sales, Bianca Camargo Penteado [UNESP]
Catalano, Shadia Muhammad Ihlaseh
author_role author
author2 Sales, Bianca Camargo Penteado [UNESP]
Catalano, Shadia Muhammad Ihlaseh
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Corteva Agriscience
dc.contributor.author.fl_str_mv Lima, Thania Rios Rossi [UNESP]
Sales, Bianca Camargo Penteado [UNESP]
Catalano, Shadia Muhammad Ihlaseh
dc.subject.por.fl_str_mv Cytotoxicity
Epithelial cells
In vivo
Molecular biology
Scanning-electron microscopy
Urinary bladder
topic Cytotoxicity
Epithelial cells
In vivo
Molecular biology
Scanning-electron microscopy
Urinary bladder
description The urinary bladder is a target organ of several toxic agents. Exposure to those agents induces mild-to-severe changes, which can be evaluated by different methods. Among them, the scanning-electron microscopy (SEM) is the “gold standard” for characterizing urothelial damage since it provides high-definition images, making it possible to detect early lesions on the surface of the urinary bladder. In addition, molecular technologies allow detecting changes in genetic material and investigating the interaction between genes and environmental stress in disease causation. The urinary bladder epithelium is where the most common type of bladder cancer occurs in humans, that is, the transitional-cell carcinoma (TCC). In animal models, the TCC can be similar to the disease in humans. Techniques to evaluate urothelium in experimental models aid in the comprehension of risk factors for urothelial carcinogenesis.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:49:57Z
2021-06-25T10:49:57Z
2021-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/978-1-0716-1091-6_8
Methods in Molecular Biology, v. 2240, p. 93-102.
1940-6029
1064-3745
http://hdl.handle.net/11449/207165
10.1007/978-1-0716-1091-6_8
2-s2.0-85099690919
url http://dx.doi.org/10.1007/978-1-0716-1091-6_8
http://hdl.handle.net/11449/207165
identifier_str_mv Methods in Molecular Biology, v. 2240, p. 93-102.
1940-6029
1064-3745
10.1007/978-1-0716-1091-6_8
2-s2.0-85099690919
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Methods in Molecular Biology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 93-102
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1810021388348555264

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