Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina

Detalhes bibliográficos
Autor(a) principal: Prado Teles Fregonesi, Cristina Elena [UNESP]
Data de Publicação: 2004
Outros Autores: Molinari, Sônia Lucy, De Miranda Neto, Marcílio Hubner
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4025/actascibiolsci.v26i1.1667
http://hdl.handle.net/11449/67613
Resumo: The aim of this study was to analyze the morphoquantitative features of the nitrergic myenteric neurons from the body of the stomach of diabetic rats. The body of the stomach of five normoglicemic rats and of five diabetic rats were prepared as whole-mounts stained by the histochemical technique of NADPH-diaphorase. Decreased body weight and increased daily ingestion of water, fast glicemia and glycated hemoglobin were verified in diabetic animals. According to the data obtained, significant difference in the density of nitrergic neurons was not observed between the two groups, but the areas of the neuronal cell body profiles in the diabetic rats were significantly larger. Results showed that the streptozotocin that induced diabetes does not accelerate the death of the nitrergic neurons, but increases the expression of these cells.
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spelling Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocinaEvaluation of the population of NADPH-diaphorase positive myenteric neurons from the body of the stomach of diabetic rats induced by streptozotocinDiabetesMyenteric plexusNitrergic neuronsStomach of ratshemoglobinreduced nicotinamide adenine dinucleotide phosphate dehydrogenasestreptozocinwateranimal experimentanimal modelcell deathcontrolled studydiabetes mellitusmyenteric plexusnitrergic nervenonhumanratstomachAnimaliaThe aim of this study was to analyze the morphoquantitative features of the nitrergic myenteric neurons from the body of the stomach of diabetic rats. The body of the stomach of five normoglicemic rats and of five diabetic rats were prepared as whole-mounts stained by the histochemical technique of NADPH-diaphorase. Decreased body weight and increased daily ingestion of water, fast glicemia and glycated hemoglobin were verified in diabetic animals. According to the data obtained, significant difference in the density of nitrergic neurons was not observed between the two groups, but the areas of the neuronal cell body profiles in the diabetic rats were significantly larger. Results showed that the streptozotocin that induced diabetes does not accelerate the death of the nitrergic neurons, but increases the expression of these cells.Departamento de Fisioterapia Faculdade de Ciências e Tecnologia Universidade Estadual Paulista, Rua Roberto Simonsen, 305, 19060-900, Pres. Prudente, Sao PauloDepartamento de Ciências Morfofisiológicas Universidade Estadual de Maringá, Av. Colombo, 5790, 87020-9000, Maringa, ParanaDepartamento de Fisioterapia Faculdade de Ciências e Tecnologia Universidade Estadual Paulista, Rua Roberto Simonsen, 305, 19060-900, Pres. Prudente, Sao PauloUniversidade Estadual Paulista (Unesp)Universidade Estadual de Maringá (UEM)Prado Teles Fregonesi, Cristina Elena [UNESP]Molinari, Sônia LucyDe Miranda Neto, Marcílio Hubner2014-05-27T11:21:01Z2014-05-27T11:21:01Z2004-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article107-112application/pdfhttp://dx.doi.org/10.4025/actascibiolsci.v26i1.1667Acta Scientiarum - Biological Sciences, v. 26, n. 1, p. 107-112, 2004.1679-9283http://hdl.handle.net/11449/6761310.4025/actascibiolsci.v26i1.16672-s2.0-336455074362-s2.0-33645507436.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporActa Scientiarum: Biological Sciences0,208info:eu-repo/semantics/openAccess2024-01-15T06:25:52Zoai:repositorio.unesp.br:11449/67613Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-15T06:25:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina
Evaluation of the population of NADPH-diaphorase positive myenteric neurons from the body of the stomach of diabetic rats induced by streptozotocin
title Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina
spellingShingle Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina
Prado Teles Fregonesi, Cristina Elena [UNESP]
Diabetes
Myenteric plexus
Nitrergic neurons
Stomach of rats
hemoglobin
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
streptozocin
water
animal experiment
animal model
cell death
controlled study
diabetes mellitus
myenteric plexus
nitrergic nerve
nonhuman
rat
stomach
Animalia
title_short Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina
title_full Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina
title_fullStr Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina
title_full_unstemmed Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina
title_sort Avaliação da população de neurônios mioentéricos NADPH-diaforase positivos do corpo do estômago de ratos com diabetes crônico induzido pela estreptozootocina
author Prado Teles Fregonesi, Cristina Elena [UNESP]
author_facet Prado Teles Fregonesi, Cristina Elena [UNESP]
Molinari, Sônia Lucy
De Miranda Neto, Marcílio Hubner
author_role author
author2 Molinari, Sônia Lucy
De Miranda Neto, Marcílio Hubner
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Maringá (UEM)
dc.contributor.author.fl_str_mv Prado Teles Fregonesi, Cristina Elena [UNESP]
Molinari, Sônia Lucy
De Miranda Neto, Marcílio Hubner
dc.subject.por.fl_str_mv Diabetes
Myenteric plexus
Nitrergic neurons
Stomach of rats
hemoglobin
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
streptozocin
water
animal experiment
animal model
cell death
controlled study
diabetes mellitus
myenteric plexus
nitrergic nerve
nonhuman
rat
stomach
Animalia
topic Diabetes
Myenteric plexus
Nitrergic neurons
Stomach of rats
hemoglobin
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
streptozocin
water
animal experiment
animal model
cell death
controlled study
diabetes mellitus
myenteric plexus
nitrergic nerve
nonhuman
rat
stomach
Animalia
description The aim of this study was to analyze the morphoquantitative features of the nitrergic myenteric neurons from the body of the stomach of diabetic rats. The body of the stomach of five normoglicemic rats and of five diabetic rats were prepared as whole-mounts stained by the histochemical technique of NADPH-diaphorase. Decreased body weight and increased daily ingestion of water, fast glicemia and glycated hemoglobin were verified in diabetic animals. According to the data obtained, significant difference in the density of nitrergic neurons was not observed between the two groups, but the areas of the neuronal cell body profiles in the diabetic rats were significantly larger. Results showed that the streptozotocin that induced diabetes does not accelerate the death of the nitrergic neurons, but increases the expression of these cells.
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
2014-05-27T11:21:01Z
2014-05-27T11:21:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4025/actascibiolsci.v26i1.1667
Acta Scientiarum - Biological Sciences, v. 26, n. 1, p. 107-112, 2004.
1679-9283
http://hdl.handle.net/11449/67613
10.4025/actascibiolsci.v26i1.1667
2-s2.0-33645507436
2-s2.0-33645507436.pdf
url http://dx.doi.org/10.4025/actascibiolsci.v26i1.1667
http://hdl.handle.net/11449/67613
identifier_str_mv Acta Scientiarum - Biological Sciences, v. 26, n. 1, p. 107-112, 2004.
1679-9283
10.4025/actascibiolsci.v26i1.1667
2-s2.0-33645507436
2-s2.0-33645507436.pdf
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Acta Scientiarum: Biological Sciences
0,208
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 107-112
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965629607837696

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