Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approach
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/s0037-86822010000600005 http://hdl.handle.net/11449/226188 |
Resumo: | Introduction: Multidrug-resistant Pseudomonas aeruginosa is a major threat in healthcare settings. The use of antimicrobials can influence the incidence of resistant strains by direct and indirect mechanisms. The latter can be addressed by ecological studies. Methods: Our group attempted to analyze the relation between the use of antipseudomonal drugs and the incidence of MDR-PA among 18 units from a 400-bed teaching hospital. The study had a retrospective, ecological design, comprising data from 2004 and 2005. Data on the use of four antimicrobials (amikacin, ciprofloxacin, ceftazidime and imipenem) were tested for correlation with the incidence of MDR-PA (defined as isolates resistant to the four antimicrobials of interest) in clinical cultures. Univariate and multivariate linear regression analyses were performed. Results: Significant correlations were determined between use and resistance for all antimicrobials in the univariate analysis: amikacin (standardized correlation coefficient = 0.73, p = 0.001); ciprofloxacin (0.71, p = 0.001); ceftazidime (0.61, p = 0.007) and imipenem (0.87, p < 0.001). In multivariate analysis, only imipenem (0.67, p = 0.01) was independently related to the incidence of multidrug-resistant strains. Conclusions: These findings share similarities with those reported in individual-based observational studies, with possible implications for infection control. |
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Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approachUso de antimicrobianos e incidência de pseudomonas aeruginosa multidroga-resistente em um hospital de ensino: Uma abordagem ecológicaAntimicrobial resistanceEcological studyPseudomonas aeruginosaIntroduction: Multidrug-resistant Pseudomonas aeruginosa is a major threat in healthcare settings. The use of antimicrobials can influence the incidence of resistant strains by direct and indirect mechanisms. The latter can be addressed by ecological studies. Methods: Our group attempted to analyze the relation between the use of antipseudomonal drugs and the incidence of MDR-PA among 18 units from a 400-bed teaching hospital. The study had a retrospective, ecological design, comprising data from 2004 and 2005. Data on the use of four antimicrobials (amikacin, ciprofloxacin, ceftazidime and imipenem) were tested for correlation with the incidence of MDR-PA (defined as isolates resistant to the four antimicrobials of interest) in clinical cultures. Univariate and multivariate linear regression analyses were performed. Results: Significant correlations were determined between use and resistance for all antimicrobials in the univariate analysis: amikacin (standardized correlation coefficient = 0.73, p = 0.001); ciprofloxacin (0.71, p = 0.001); ceftazidime (0.61, p = 0.007) and imipenem (0.87, p < 0.001). In multivariate analysis, only imipenem (0.67, p = 0.01) was independently related to the incidence of multidrug-resistant strains. Conclusions: These findings share similarities with those reported in individual-based observational studies, with possible implications for infection control.Department of Tropical Diseases Botucatu School of Medicine São Paulo State University, Botucatu, SPBauru State Hospital Botucatu School of Medicine São Paulo State University, Bauru, SPDepartment of Tropical Diseases Botucatu School of Medicine São Paulo State University, Botucatu, SPBauru State Hospital Botucatu School of Medicine São Paulo State University, Bauru, SPUniversidade Estadual Paulista (UNESP)das Neves, Mariana Tresoldi [UNESP]de Lorenzo, Mariana Eliza Pinto [UNESP]Almeida, Ricardo Augusto Monteiro Barros [UNESP]Fortaleza, Carlos Magno Castelo Branco [UNESP]2022-04-28T21:50:35Z2022-04-28T21:50:35Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article629-632http://dx.doi.org/10.1590/s0037-86822010000600005Revista da Sociedade Brasileira de Medicina Tropical, v. 43, n. 6, p. 629-632, 2010.0037-8682http://hdl.handle.net/11449/22618810.1590/s0037-868220100006000052-s2.0-78651079571Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista da Sociedade Brasileira de Medicina Tropicalinfo:eu-repo/semantics/openAccess2022-04-28T21:50:35Zoai:repositorio.unesp.br:11449/226188Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T21:50:35Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approach Uso de antimicrobianos e incidência de pseudomonas aeruginosa multidroga-resistente em um hospital de ensino: Uma abordagem ecológica |
title |
Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approach |
spellingShingle |
Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approach das Neves, Mariana Tresoldi [UNESP] Antimicrobial resistance Ecological study Pseudomonas aeruginosa |
title_short |
Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approach |
title_full |
Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approach |
title_fullStr |
Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approach |
title_full_unstemmed |
Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approach |
title_sort |
Antimicrobial use and incidence of multidrug-resistant pseudomonas aeruginosa in a teaching hospital: An ecological approach |
author |
das Neves, Mariana Tresoldi [UNESP] |
author_facet |
das Neves, Mariana Tresoldi [UNESP] de Lorenzo, Mariana Eliza Pinto [UNESP] Almeida, Ricardo Augusto Monteiro Barros [UNESP] Fortaleza, Carlos Magno Castelo Branco [UNESP] |
author_role |
author |
author2 |
de Lorenzo, Mariana Eliza Pinto [UNESP] Almeida, Ricardo Augusto Monteiro Barros [UNESP] Fortaleza, Carlos Magno Castelo Branco [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
das Neves, Mariana Tresoldi [UNESP] de Lorenzo, Mariana Eliza Pinto [UNESP] Almeida, Ricardo Augusto Monteiro Barros [UNESP] Fortaleza, Carlos Magno Castelo Branco [UNESP] |
dc.subject.por.fl_str_mv |
Antimicrobial resistance Ecological study Pseudomonas aeruginosa |
topic |
Antimicrobial resistance Ecological study Pseudomonas aeruginosa |
description |
Introduction: Multidrug-resistant Pseudomonas aeruginosa is a major threat in healthcare settings. The use of antimicrobials can influence the incidence of resistant strains by direct and indirect mechanisms. The latter can be addressed by ecological studies. Methods: Our group attempted to analyze the relation between the use of antipseudomonal drugs and the incidence of MDR-PA among 18 units from a 400-bed teaching hospital. The study had a retrospective, ecological design, comprising data from 2004 and 2005. Data on the use of four antimicrobials (amikacin, ciprofloxacin, ceftazidime and imipenem) were tested for correlation with the incidence of MDR-PA (defined as isolates resistant to the four antimicrobials of interest) in clinical cultures. Univariate and multivariate linear regression analyses were performed. Results: Significant correlations were determined between use and resistance for all antimicrobials in the univariate analysis: amikacin (standardized correlation coefficient = 0.73, p = 0.001); ciprofloxacin (0.71, p = 0.001); ceftazidime (0.61, p = 0.007) and imipenem (0.87, p < 0.001). In multivariate analysis, only imipenem (0.67, p = 0.01) was independently related to the incidence of multidrug-resistant strains. Conclusions: These findings share similarities with those reported in individual-based observational studies, with possible implications for infection control. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 2022-04-28T21:50:35Z 2022-04-28T21:50:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/s0037-86822010000600005 Revista da Sociedade Brasileira de Medicina Tropical, v. 43, n. 6, p. 629-632, 2010. 0037-8682 http://hdl.handle.net/11449/226188 10.1590/s0037-86822010000600005 2-s2.0-78651079571 |
url |
http://dx.doi.org/10.1590/s0037-86822010000600005 http://hdl.handle.net/11449/226188 |
identifier_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical, v. 43, n. 6, p. 629-632, 2010. 0037-8682 10.1590/s0037-86822010000600005 2-s2.0-78651079571 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
629-632 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1803046313654222848 |