Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2147/IJN.S285805 http://hdl.handle.net/11449/209964 |
Resumo: | Background: Nanostructured surface modifications of Ti-based biomaterials are moving up from a highly-promising to a successfully-implemented approach to developing safe and reliable implants. Methods: The study's main objective is to help consolidate the knowledge and identify the more suitable experimental strategies related to TiO2 nanotubes-modified surfaces. In this sense, it proposes the thorough investigation of two optimized nanotubes morphologies in terms of their biological activity (cell cytotoxicity, alkaline phosphatase activity, alizarin red mineralization test, and cellular adhesion) and their electrochemical behavior in simulated body fluid (SBF) electrolyte. Layers of small-short and large-long nanotubes were prepared and investigated in their amorphous and crystallized states and compared to non-anodized samples. Results: Results show that much more than the surface area development associated with the nanotubes' growth; it is the heat treatment-induced change from amorphous to crystalline anatase-rutile structures that ensure enhanced biological activity coupled to high corrosion resistance. Conclusion: Compared to both non-anodized and amorphous nanotubes layers, the crystallized nano-structures' outstanding bioactivity was related to the remarkable increase in their hydrophilic behavior, while the enhanced electrochemical stability was ascribed to the thickening of the dense ruble barrier layer at the Ti surface beneath the nanotubes. |
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Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistancesurface modificationTiO2 nanotubescommercially pure titaniumbioactivityBackground: Nanostructured surface modifications of Ti-based biomaterials are moving up from a highly-promising to a successfully-implemented approach to developing safe and reliable implants. Methods: The study's main objective is to help consolidate the knowledge and identify the more suitable experimental strategies related to TiO2 nanotubes-modified surfaces. In this sense, it proposes the thorough investigation of two optimized nanotubes morphologies in terms of their biological activity (cell cytotoxicity, alkaline phosphatase activity, alizarin red mineralization test, and cellular adhesion) and their electrochemical behavior in simulated body fluid (SBF) electrolyte. Layers of small-short and large-long nanotubes were prepared and investigated in their amorphous and crystallized states and compared to non-anodized samples. Results: Results show that much more than the surface area development associated with the nanotubes' growth; it is the heat treatment-induced change from amorphous to crystalline anatase-rutile structures that ensure enhanced biological activity coupled to high corrosion resistance. Conclusion: Compared to both non-anodized and amorphous nanotubes layers, the crystallized nano-structures' outstanding bioactivity was related to the remarkable increase in their hydrophilic behavior, while the enhanced electrochemical stability was ascribed to the thickening of the dense ruble barrier layer at the Ti surface beneath the nanotubes.French Committee for the Evaluation of Academic and Scientific Cooperation with Brazil (COFECUB)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Khalifa Univ Sci & Technol, Chem Engn Dept, Abu Dhabi 127788, U Arab EmiratesUniv Grenoble Alpes, Univ Savoie Mt Blanc, GrenoblelNP LEPMI, CNRS, F-38000 Grenoble, FranceFed Inst Educ Sci & Technol Piaui, BR-64053390 Teresina, BrazilUFPI Fed Univ Piaui, Interdisciplinary Lab Adv Mat, BioMatLab Grp, Mat Sci & Engn Grad Program, BR-64049550 Teresina, BrazilSao Paulo State Univ, Dept Biosci & Oral Diag, Inst Sci & Technol, BR-12245000 Sao Jose Dos Campos, BrazilUniv Fed Piaui, Dept Phys, BR-64049550 Teresina, BrazilUniv Fed Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, BrazilSao Paulo State Univ, Dept Biosci & Oral Diag, Inst Sci & Technol, BR-12245000 Sao Jose Dos Campos, BrazilCAPES: 88887.321581/2019-00FAPESP: 2012/13179-6CNPq: 311531/2020-2CNPq: 301429/2017-0CNPq: 409847/2016-0CNPq: 310883/2020-2CNPq: 404683/2018-5Dove Medical Press LtdKhalifa Univ Sci & TechnolUniv Grenoble AlpesFed Inst Educ Sci & Technol PiauiUFPI Fed Univ PiauiUniversidade Estadual Paulista (Unesp)Univ Fed PiauiUniversidade Federal de São Carlos (UFSCar)Nogueira, Ricardo PereiraUchoa, Jose DeuzimarHilario, FannySantana-Melo, Gabriela de Fatima [UNESP]Reis de Vasconcellos, Luana Marotta [UNESP]Marciano, Fernanda RobertaRoche, VirginieJorge Junior, Alberto MoreiraLobo, Anderson Oliveira2021-06-25T12:35:02Z2021-06-25T12:35:02Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article667-682http://dx.doi.org/10.2147/IJN.S285805International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 16, p. 667-682, 2021.1178-2013http://hdl.handle.net/11449/20996410.2147/IJN.S285805WOS:000611668100001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal Of Nanomedicineinfo:eu-repo/semantics/openAccess2021-10-23T19:50:12Zoai:repositorio.unesp.br:11449/209964Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:45:25.783119Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance |
title |
Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance |
spellingShingle |
Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance Nogueira, Ricardo Pereira surface modification TiO2 nanotubes commercially pure titanium bioactivity |
title_short |
Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance |
title_full |
Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance |
title_fullStr |
Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance |
title_full_unstemmed |
Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance |
title_sort |
Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance |
author |
Nogueira, Ricardo Pereira |
author_facet |
Nogueira, Ricardo Pereira Uchoa, Jose Deuzimar Hilario, Fanny Santana-Melo, Gabriela de Fatima [UNESP] Reis de Vasconcellos, Luana Marotta [UNESP] Marciano, Fernanda Roberta Roche, Virginie Jorge Junior, Alberto Moreira Lobo, Anderson Oliveira |
author_role |
author |
author2 |
Uchoa, Jose Deuzimar Hilario, Fanny Santana-Melo, Gabriela de Fatima [UNESP] Reis de Vasconcellos, Luana Marotta [UNESP] Marciano, Fernanda Roberta Roche, Virginie Jorge Junior, Alberto Moreira Lobo, Anderson Oliveira |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Khalifa Univ Sci & Technol Univ Grenoble Alpes Fed Inst Educ Sci & Technol Piaui UFPI Fed Univ Piaui Universidade Estadual Paulista (Unesp) Univ Fed Piaui Universidade Federal de São Carlos (UFSCar) |
dc.contributor.author.fl_str_mv |
Nogueira, Ricardo Pereira Uchoa, Jose Deuzimar Hilario, Fanny Santana-Melo, Gabriela de Fatima [UNESP] Reis de Vasconcellos, Luana Marotta [UNESP] Marciano, Fernanda Roberta Roche, Virginie Jorge Junior, Alberto Moreira Lobo, Anderson Oliveira |
dc.subject.por.fl_str_mv |
surface modification TiO2 nanotubes commercially pure titanium bioactivity |
topic |
surface modification TiO2 nanotubes commercially pure titanium bioactivity |
description |
Background: Nanostructured surface modifications of Ti-based biomaterials are moving up from a highly-promising to a successfully-implemented approach to developing safe and reliable implants. Methods: The study's main objective is to help consolidate the knowledge and identify the more suitable experimental strategies related to TiO2 nanotubes-modified surfaces. In this sense, it proposes the thorough investigation of two optimized nanotubes morphologies in terms of their biological activity (cell cytotoxicity, alkaline phosphatase activity, alizarin red mineralization test, and cellular adhesion) and their electrochemical behavior in simulated body fluid (SBF) electrolyte. Layers of small-short and large-long nanotubes were prepared and investigated in their amorphous and crystallized states and compared to non-anodized samples. Results: Results show that much more than the surface area development associated with the nanotubes' growth; it is the heat treatment-induced change from amorphous to crystalline anatase-rutile structures that ensure enhanced biological activity coupled to high corrosion resistance. Conclusion: Compared to both non-anodized and amorphous nanotubes layers, the crystallized nano-structures' outstanding bioactivity was related to the remarkable increase in their hydrophilic behavior, while the enhanced electrochemical stability was ascribed to the thickening of the dense ruble barrier layer at the Ti surface beneath the nanotubes. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T12:35:02Z 2021-06-25T12:35:02Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2147/IJN.S285805 International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 16, p. 667-682, 2021. 1178-2013 http://hdl.handle.net/11449/209964 10.2147/IJN.S285805 WOS:000611668100001 |
url |
http://dx.doi.org/10.2147/IJN.S285805 http://hdl.handle.net/11449/209964 |
identifier_str_mv |
International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 16, p. 667-682, 2021. 1178-2013 10.2147/IJN.S285805 WOS:000611668100001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal Of Nanomedicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
667-682 |
dc.publisher.none.fl_str_mv |
Dove Medical Press Ltd |
publisher.none.fl_str_mv |
Dove Medical Press Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128557193363456 |