Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro

• Autor(a) principal: Tommasini Grotto, Rejane Maria [UNESP]
• Data de Publicação: 2016
• Outros Autores: Cantao, Natalia Mirele [UNESP], Padovani, Juliana Lara [UNESP], Souza, Lenice do Rosario de [UNESP], Silva, Giovanni Faria [UNESP], Ferrasi, Adriana Camargo [UNESP], Moura Campos Pardini, Maria Ines de [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/0037-8682-0105-2016; http://hdl.handle.net/11449/161869
• topic: Hepatitis C virus; Human platelets antigen polymorphisms; Human immunodeficiency virus

Introduction: In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. Methods: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. Results: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. Conclusions: HIV-platelet ligation could be more efficient than HCV-platelet interaction. Further, the HPA-1b allele seems to influence the interaction of platelets with HCV.