Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp

Detalhes bibliográficos
Autor(a) principal: da Silva, Perla V. B.
Data de Publicação: 2018
Outros Autores: Ramiro, Marianne M., Iriguchi, Edna K. K., Corrêa, William A., Lowe, Jennifer, Cardoso, Claudia A. L., Arena, Arielle C., Kassuya, Cândida A. L., Muzzi, Rozanna M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/14786419.2018.1446006
http://hdl.handle.net/11449/170743
Resumo: This study evaluated the hypoglycemic effect of the oil extracted from the Acrocomia aculeata pulp (OPAC) in normoglycemic rats and streptozotocin (STZ), fructose-induced diabetic rat models and its in vitro antioxidant and cytotoxic potential. OPAC (3, 30 or 300 mg/kg, v.o.) significantly decreased (p < 0.05) the high glucose levels induced by a high fructose-diet in rats. Persistent treatment with OPAC for 24 days also reduced the high plasmatic glucose induced by STZ. In normoglycemic animals, OPAC significantly decreased glucose levels. While A. aculeata oil exhibited good in vitro antioxidant activity, no sign of cytotoxicity was observed in LLC-PK1 cells (5–500 μg/mL). OPAC has antidiabetic and antioxidant activities without causing in vitro cytotoxicity.
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spelling Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulpantioxidant activityhypoglycemic activityMedicinal plantsThis study evaluated the hypoglycemic effect of the oil extracted from the Acrocomia aculeata pulp (OPAC) in normoglycemic rats and streptozotocin (STZ), fructose-induced diabetic rat models and its in vitro antioxidant and cytotoxic potential. OPAC (3, 30 or 300 mg/kg, v.o.) significantly decreased (p < 0.05) the high glucose levels induced by a high fructose-diet in rats. Persistent treatment with OPAC for 24 days also reduced the high plasmatic glucose induced by STZ. In normoglycemic animals, OPAC significantly decreased glucose levels. While A. aculeata oil exhibited good in vitro antioxidant activity, no sign of cytotoxicity was observed in LLC-PK1 cells (5–500 μg/mL). OPAC has antidiabetic and antioxidant activities without causing in vitro cytotoxicity.Federal University of Grande Dourados, Dourados, BrazilFederal University of Rio de Janeiro, Rio de Janeiro, BrazilMato Grosso do Sul State University, Dourados, BrazilInstitute of Biosciences of Botucatu, São Paulo State University (UNESP), São Paulo, BrazilUniversidade Estadual Paulista (Unesp)da Silva, Perla V. B.Ramiro, Marianne M.Iriguchi, Edna K. K.Corrêa, William A.Lowe, JenniferCardoso, Claudia A. L.Arena, Arielle C.Kassuya, Cândida A. L.Muzzi, Rozanna M.2018-12-11T16:52:15Z2018-12-11T16:52:15Z2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-4application/pdfhttp://dx.doi.org/10.1080/14786419.2018.1446006Natural Product Research, p. 1-4.1478-64271478-6419http://hdl.handle.net/11449/17074310.1080/14786419.2018.14460062-s2.0-850429447352-s2.0-85042944735.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Research0,671info:eu-repo/semantics/openAccess2023-10-25T06:07:44Zoai:repositorio.unesp.br:11449/170743Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-25T06:07:44Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp
title Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp
spellingShingle Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp
da Silva, Perla V. B.
antioxidant activity
hypoglycemic activity
Medicinal plants
title_short Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp
title_full Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp
title_fullStr Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp
title_full_unstemmed Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp
title_sort Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp
author da Silva, Perla V. B.
author_facet da Silva, Perla V. B.
Ramiro, Marianne M.
Iriguchi, Edna K. K.
Corrêa, William A.
Lowe, Jennifer
Cardoso, Claudia A. L.
Arena, Arielle C.
Kassuya, Cândida A. L.
Muzzi, Rozanna M.
author_role author
author2 Ramiro, Marianne M.
Iriguchi, Edna K. K.
Corrêa, William A.
Lowe, Jennifer
Cardoso, Claudia A. L.
Arena, Arielle C.
Kassuya, Cândida A. L.
Muzzi, Rozanna M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv da Silva, Perla V. B.
Ramiro, Marianne M.
Iriguchi, Edna K. K.
Corrêa, William A.
Lowe, Jennifer
Cardoso, Claudia A. L.
Arena, Arielle C.
Kassuya, Cândida A. L.
Muzzi, Rozanna M.
dc.subject.por.fl_str_mv antioxidant activity
hypoglycemic activity
Medicinal plants
topic antioxidant activity
hypoglycemic activity
Medicinal plants
description This study evaluated the hypoglycemic effect of the oil extracted from the Acrocomia aculeata pulp (OPAC) in normoglycemic rats and streptozotocin (STZ), fructose-induced diabetic rat models and its in vitro antioxidant and cytotoxic potential. OPAC (3, 30 or 300 mg/kg, v.o.) significantly decreased (p < 0.05) the high glucose levels induced by a high fructose-diet in rats. Persistent treatment with OPAC for 24 days also reduced the high plasmatic glucose induced by STZ. In normoglycemic animals, OPAC significantly decreased glucose levels. While A. aculeata oil exhibited good in vitro antioxidant activity, no sign of cytotoxicity was observed in LLC-PK1 cells (5–500 μg/mL). OPAC has antidiabetic and antioxidant activities without causing in vitro cytotoxicity.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T16:52:15Z
2018-12-11T16:52:15Z
2018-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/14786419.2018.1446006
Natural Product Research, p. 1-4.
1478-6427
1478-6419
http://hdl.handle.net/11449/170743
10.1080/14786419.2018.1446006
2-s2.0-85042944735
2-s2.0-85042944735.pdf
url http://dx.doi.org/10.1080/14786419.2018.1446006
http://hdl.handle.net/11449/170743
identifier_str_mv Natural Product Research, p. 1-4.
1478-6427
1478-6419
10.1080/14786419.2018.1446006
2-s2.0-85042944735
2-s2.0-85042944735.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Natural Product Research
0,671
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-4
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964691038994432

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