Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp)
Autor(a) principal: | |
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Data de Publicação: | 1989 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/230840 |
Resumo: | Intravenous glucose tolerance tests and measurements with [6-3H]glucose of rate of glucose replacement, transit time, and body glucose mass were performed in fed and fasted Hoplias malabaricus. Both glycemia levels and the rate of decline of blood glucose following intravenous administration of 500 mg/kg glucose were significantly lower in 60-day-fasted than in fed fish. Changes in plasma free fatty acids were opposite to those in blood glucose. The rate of glucose replacement, calculated graphically from mean ± 3 SE plots of glucose specific radioactivity, was 0.71 (0.66-0.77) mg·kg-1·min-1 in fed H. malabaricus and decreased to 0.51 (0.46-0.56) mg·kg-1·min-1 after 60 days without food, with a concomitant reduction of body glucose mass (m(min), 138 vs. 83 mg/kg). In fish starved for 10 mo the rate of glucose replacement and body glucose mass were further reduced to 0.35 (0.29-0.42) mg·kg-1·min-1 and 57 mg/kg (m(min)), respectively. It is concluded that a progressive decline in the rate of glucose utilization contributes to the adaptation of fish to prolonged fasting. |
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Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp)Intravenous glucose tolerance tests and measurements with [6-3H]glucose of rate of glucose replacement, transit time, and body glucose mass were performed in fed and fasted Hoplias malabaricus. Both glycemia levels and the rate of decline of blood glucose following intravenous administration of 500 mg/kg glucose were significantly lower in 60-day-fasted than in fed fish. Changes in plasma free fatty acids were opposite to those in blood glucose. The rate of glucose replacement, calculated graphically from mean ± 3 SE plots of glucose specific radioactivity, was 0.71 (0.66-0.77) mg·kg-1·min-1 in fed H. malabaricus and decreased to 0.51 (0.46-0.56) mg·kg-1·min-1 after 60 days without food, with a concomitant reduction of body glucose mass (m(min), 138 vs. 83 mg/kg). In fish starved for 10 mo the rate of glucose replacement and body glucose mass were further reduced to 0.35 (0.29-0.42) mg·kg-1·min-1 and 57 mg/kg (m(min)), respectively. It is concluded that a progressive decline in the rate of glucose utilization contributes to the adaptation of fish to prolonged fasting.Department of Morphology and Physiology, State University of Sao Paulo School of Veterinary Medicine, Jaboticabal, CP 14870, Sao PauloUniversidade de São Paulo (USP)Machado, C. R.Garofalo, M. A.R.Roselino, J. E.S.Kettelhut, I. C.Migliorini, R. H.2022-04-29T08:42:20Z2022-04-29T08:42:20Z1989-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 256, n. 3, 1989.0002-9513http://hdl.handle.net/11449/2308402-s2.0-0024516328Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiologyinfo:eu-repo/semantics/openAccess2024-06-06T18:41:32Zoai:repositorio.unesp.br:11449/230840Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:59:59.966108Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp) |
title |
Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp) |
spellingShingle |
Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp) Machado, C. R. |
title_short |
Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp) |
title_full |
Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp) |
title_fullStr |
Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp) |
title_full_unstemmed |
Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp) |
title_sort |
Effect of fasting on glucose turnover in a carnivorous fish (Hoplias sp) |
author |
Machado, C. R. |
author_facet |
Machado, C. R. Garofalo, M. A.R. Roselino, J. E.S. Kettelhut, I. C. Migliorini, R. H. |
author_role |
author |
author2 |
Garofalo, M. A.R. Roselino, J. E.S. Kettelhut, I. C. Migliorini, R. H. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Machado, C. R. Garofalo, M. A.R. Roselino, J. E.S. Kettelhut, I. C. Migliorini, R. H. |
description |
Intravenous glucose tolerance tests and measurements with [6-3H]glucose of rate of glucose replacement, transit time, and body glucose mass were performed in fed and fasted Hoplias malabaricus. Both glycemia levels and the rate of decline of blood glucose following intravenous administration of 500 mg/kg glucose were significantly lower in 60-day-fasted than in fed fish. Changes in plasma free fatty acids were opposite to those in blood glucose. The rate of glucose replacement, calculated graphically from mean ± 3 SE plots of glucose specific radioactivity, was 0.71 (0.66-0.77) mg·kg-1·min-1 in fed H. malabaricus and decreased to 0.51 (0.46-0.56) mg·kg-1·min-1 after 60 days without food, with a concomitant reduction of body glucose mass (m(min), 138 vs. 83 mg/kg). In fish starved for 10 mo the rate of glucose replacement and body glucose mass were further reduced to 0.35 (0.29-0.42) mg·kg-1·min-1 and 57 mg/kg (m(min)), respectively. It is concluded that a progressive decline in the rate of glucose utilization contributes to the adaptation of fish to prolonged fasting. |
publishDate |
1989 |
dc.date.none.fl_str_mv |
1989-01-01 2022-04-29T08:42:20Z 2022-04-29T08:42:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 256, n. 3, 1989. 0002-9513 http://hdl.handle.net/11449/230840 2-s2.0-0024516328 |
identifier_str_mv |
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 256, n. 3, 1989. 0002-9513 2-s2.0-0024516328 |
url |
http://hdl.handle.net/11449/230840 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128734506516480 |