Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Bruno
Data de Publicação: 2014
Outros Autores: Santana, Aline Alves, Santamarina, Aline Boveto, Oyama, Lila Missae, Caperuto, Erico Chagas, Souza, Claudio Teodoro de, Barboza, Catarina de Andrade, Rocha, Leandro Yanase, Figueroa, Diego, Mostarda, Cristiano, Irigoyen, Maria Claudia, Lira, Fabio Santos [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2014/207131
http://hdl.handle.net/11449/113381
Resumo: The aim of this study was to evaluate the effects of exercise training (ET, 50-70% of VO2max, 5 days/week) and detraining (DT) on inflammatory and metabolic profile after myocardial infarction (MI) in rats. Male Wistar rats were divided into control (C, n = 8), sedentary infarcted (SI, n = 9), trained infarcted (TI, n = 10; 3 months of ET), and detrained infarcted (DI, n = 11; 2 months of ET + 1 month of DT). After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated. ET after MI improved cardiac and vascular autonomic modulation, and these benefits were correlated with reduced inflammatory cytokines on the heart and adipose tissue. These positive changes were sustained even after 1 month of detraining. No expressive changes were observed in oxidative stress and lipolytic pathway in experimental groups. In conclusion, our results strongly suggest that the autonomic improvement promoted by ET, and maintained even after the detraining period, was associated with reduced inflammatory profile in the left ventricle and adipose tissue of rats subjected to MI. These data encourage enhancing cardiovascular autonomic function as a therapeutic strategy for the treatment of inflammatory process triggered by MI.
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spelling Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous SystemThe aim of this study was to evaluate the effects of exercise training (ET, 50-70% of VO2max, 5 days/week) and detraining (DT) on inflammatory and metabolic profile after myocardial infarction (MI) in rats. Male Wistar rats were divided into control (C, n = 8), sedentary infarcted (SI, n = 9), trained infarcted (TI, n = 10; 3 months of ET), and detrained infarcted (DI, n = 11; 2 months of ET + 1 month of DT). After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated. ET after MI improved cardiac and vascular autonomic modulation, and these benefits were correlated with reduced inflammatory cytokines on the heart and adipose tissue. These positive changes were sustained even after 1 month of detraining. No expressive changes were observed in oxidative stress and lipolytic pathway in experimental groups. In conclusion, our results strongly suggest that the autonomic improvement promoted by ET, and maintained even after the detraining period, was associated with reduced inflammatory profile in the left ventricle and adipose tissue of rats subjected to MI. These data encourage enhancing cardiovascular autonomic function as a therapeutic strategy for the treatment of inflammatory process triggered by MI.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Sao Judas Tadeu Univ USJT, Human Movement Lab, BR-03166000 Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Nutr Physiol Discipline, Dept Physiol, BR-04021001 Sao Paulo, BrazilUniv Extremo Catarinense UNESC, Lab Exercise Physiol & Biochem, BR-88806000 Criciuma, SC, BrazilUniv Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, BR-05403900 Sao Paulo, BrazilUniv Sao Paulo State UNESP, Dept Phys Educ, Immunometab Res Grp, BR-19060900 Presidente Prudente, SP, BrazilUniv Sao Paulo State UNESP, Dept Phys Educ, Immunometab Res Grp, BR-19060900 Presidente Prudente, SP, BrazilFAPESP: 13/14788-9FAPESP: 07/58942-0CNPq: CNPq: 563961/2010-4CNPq: 479076/2012-0CNPq: 457581/2013-1CAPES: CAPES: 074/2012CAPES: 095/2010Hindawi Publishing CorporationSao Judas Tadeu Univ USJTUniversidade de São Paulo (USP)Univ Extremo Catarinense UNESCUniversidade Estadual Paulista (Unesp)Rodrigues, BrunoSantana, Aline AlvesSantamarina, Aline BovetoOyama, Lila MissaeCaperuto, Erico ChagasSouza, Claudio Teodoro deBarboza, Catarina de AndradeRocha, Leandro YanaseFigueroa, DiegoMostarda, CristianoIrigoyen, Maria ClaudiaLira, Fabio Santos [UNESP]2014-12-03T13:11:39Z2014-12-03T13:11:39Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://dx.doi.org/10.1155/2014/207131Mediators Of Inflammation. New York: Hindawi Publishing Corporation, 13 p., 2014.0962-9351http://hdl.handle.net/11449/11338110.1155/2014/207131WOS:000338068400001WOS000338068400001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediators of Inflammation3.5491,370info:eu-repo/semantics/openAccess2024-06-18T18:18:17Zoai:repositorio.unesp.br:11449/113381Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:55:59.349236Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System
title Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System
spellingShingle Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System
Rodrigues, Bruno
title_short Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System
title_full Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System
title_fullStr Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System
title_full_unstemmed Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System
title_sort Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System
author Rodrigues, Bruno
author_facet Rodrigues, Bruno
Santana, Aline Alves
Santamarina, Aline Boveto
Oyama, Lila Missae
Caperuto, Erico Chagas
Souza, Claudio Teodoro de
Barboza, Catarina de Andrade
Rocha, Leandro Yanase
Figueroa, Diego
Mostarda, Cristiano
Irigoyen, Maria Claudia
Lira, Fabio Santos [UNESP]
author_role author
author2 Santana, Aline Alves
Santamarina, Aline Boveto
Oyama, Lila Missae
Caperuto, Erico Chagas
Souza, Claudio Teodoro de
Barboza, Catarina de Andrade
Rocha, Leandro Yanase
Figueroa, Diego
Mostarda, Cristiano
Irigoyen, Maria Claudia
Lira, Fabio Santos [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sao Judas Tadeu Univ USJT
Universidade de São Paulo (USP)
Univ Extremo Catarinense UNESC
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Rodrigues, Bruno
Santana, Aline Alves
Santamarina, Aline Boveto
Oyama, Lila Missae
Caperuto, Erico Chagas
Souza, Claudio Teodoro de
Barboza, Catarina de Andrade
Rocha, Leandro Yanase
Figueroa, Diego
Mostarda, Cristiano
Irigoyen, Maria Claudia
Lira, Fabio Santos [UNESP]
description The aim of this study was to evaluate the effects of exercise training (ET, 50-70% of VO2max, 5 days/week) and detraining (DT) on inflammatory and metabolic profile after myocardial infarction (MI) in rats. Male Wistar rats were divided into control (C, n = 8), sedentary infarcted (SI, n = 9), trained infarcted (TI, n = 10; 3 months of ET), and detrained infarcted (DI, n = 11; 2 months of ET + 1 month of DT). After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated. ET after MI improved cardiac and vascular autonomic modulation, and these benefits were correlated with reduced inflammatory cytokines on the heart and adipose tissue. These positive changes were sustained even after 1 month of detraining. No expressive changes were observed in oxidative stress and lipolytic pathway in experimental groups. In conclusion, our results strongly suggest that the autonomic improvement promoted by ET, and maintained even after the detraining period, was associated with reduced inflammatory profile in the left ventricle and adipose tissue of rats subjected to MI. These data encourage enhancing cardiovascular autonomic function as a therapeutic strategy for the treatment of inflammatory process triggered by MI.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-03T13:11:39Z
2014-12-03T13:11:39Z
2014-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2014/207131
Mediators Of Inflammation. New York: Hindawi Publishing Corporation, 13 p., 2014.
0962-9351
http://hdl.handle.net/11449/113381
10.1155/2014/207131
WOS:000338068400001
WOS000338068400001.pdf
url http://dx.doi.org/10.1155/2014/207131
http://hdl.handle.net/11449/113381
identifier_str_mv Mediators Of Inflammation. New York: Hindawi Publishing Corporation, 13 p., 2014.
0962-9351
10.1155/2014/207131
WOS:000338068400001
WOS000338068400001.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mediators of Inflammation
3.549
1,370
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv 13
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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