Beta-caseína A2 como um diferencial na qualidade do leite

• Autor(a) principal: Corbucci, Flávio Sader [UNESP]
• Data de Publicação: 2017
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/156709; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2018-07-04/000901739.pdf
• topic: Caseina; Genetica animal; Leite - Composição; Bovino de leite; Beta-casomorphin-7

Milk containing the A1 variant of beta-casein is considered a predisposing factor to human diseases mainly in genetically susceptible individuals. The present systematic review aimed to relate the advantages of milk consumption with the A2 variant of beta-casein and its applicability to industry and farmers. Using five databases, a bibliographic survey was performed with the descriptors: (bovine) AND (milk protein) AND (polymorphism OR illness) AND (beta-casein OR beta-casomorphin-7). The A1 variant of the 13 known beta-casein variants is responsible for the production of beta-casomorphine-7, mainly by enzymatic hydrolysis, which is related to the development of type 1 diabetes mellitus in children, cardiovascular diseases, allergies and autism. In contrast, the A2 variant shows no significant production of this peptide and is correlated with increases in solids and milk production. As the gene frequency of the A2 allele is higher in zebu breeds, this makes Brazil privileged because it has the herd mostly of Bos indicus animals that can be used as a genetic resource suitable for the production of milk only with the beta casein A2 protein. The selection against allelic variants A1 may be suggested, since the A2 allele may result in positive effects for the herd and in a value-added product that may represent a differential from common milk and benefits for consumer health