Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood

Detalhes bibliográficos
Autor(a) principal: Colombo, Natália Helena [UNESP]
Data de Publicação: 2016
Outros Autores: Pereira, Jesse Augusto [UNESP], Da Silva, Márjully Eduardo Rodrigues [UNESP], Ribas, Laís Fernanda Fonseca [UNESP], Parisotto, Thaís Manzano, Mattos-Graner, Renata De Oliveira, Smith, Daniel J., Duque, Cristiane [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.archoralbio.2016.03.006
http://hdl.handle.net/11449/172763
Resumo: Objective Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC.
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spelling Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhoodEarly childhood cariesGlucan binding proteinsImunoglobulin AS. mutansObjective Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC.UNESP - Univ Estadual Paulista Araçatuba Dental School Department of Pediatric Dentistry and Public Health, R. José Bonifácio, 1193Sao Francisco University Dental School Laboratory of Microbiology and Molecular BiologyUNICAMP- University of Campinas Piracicaba Dental School Department of Oral DiagnosisForsyth Institute Department of Immunology and Infectious DiseaseUNESP - Univ Estadual Paulista Araçatuba Dental School Department of Pediatric Dentistry and Public Health, R. José Bonifácio, 1193Universidade Estadual Paulista (Unesp)Laboratory of Microbiology and Molecular BiologyUniversidade Estadual de Campinas (UNICAMP)Forsyth InstituteColombo, Natália Helena [UNESP]Pereira, Jesse Augusto [UNESP]Da Silva, Márjully Eduardo Rodrigues [UNESP]Ribas, Laís Fernanda Fonseca [UNESP]Parisotto, Thaís ManzanoMattos-Graner, Renata De OliveiraSmith, Daniel J.Duque, Cristiane [UNESP]2018-12-11T17:02:05Z2018-12-11T17:02:05Z2016-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article22-27application/pdfhttp://dx.doi.org/10.1016/j.archoralbio.2016.03.006Archives of Oral Biology, v. 67, p. 22-27.1879-15060003-9969http://hdl.handle.net/11449/17276310.1016/j.archoralbio.2016.03.0062-s2.0-849622771622-s2.0-84962277162.pdf56518745094936170000-0002-2575-279XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Oral Biology0,752info:eu-repo/semantics/openAccess2024-09-19T17:57:24Zoai:repositorio.unesp.br:11449/172763Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T17:57:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood
title Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood
spellingShingle Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood
Colombo, Natália Helena [UNESP]
Early childhood caries
Glucan binding proteins
Imunoglobulin A
S. mutans
title_short Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood
title_full Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood
title_fullStr Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood
title_full_unstemmed Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood
title_sort Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood
author Colombo, Natália Helena [UNESP]
author_facet Colombo, Natália Helena [UNESP]
Pereira, Jesse Augusto [UNESP]
Da Silva, Márjully Eduardo Rodrigues [UNESP]
Ribas, Laís Fernanda Fonseca [UNESP]
Parisotto, Thaís Manzano
Mattos-Graner, Renata De Oliveira
Smith, Daniel J.
Duque, Cristiane [UNESP]
author_role author
author2 Pereira, Jesse Augusto [UNESP]
Da Silva, Márjully Eduardo Rodrigues [UNESP]
Ribas, Laís Fernanda Fonseca [UNESP]
Parisotto, Thaís Manzano
Mattos-Graner, Renata De Oliveira
Smith, Daniel J.
Duque, Cristiane [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Laboratory of Microbiology and Molecular Biology
Universidade Estadual de Campinas (UNICAMP)
Forsyth Institute
dc.contributor.author.fl_str_mv Colombo, Natália Helena [UNESP]
Pereira, Jesse Augusto [UNESP]
Da Silva, Márjully Eduardo Rodrigues [UNESP]
Ribas, Laís Fernanda Fonseca [UNESP]
Parisotto, Thaís Manzano
Mattos-Graner, Renata De Oliveira
Smith, Daniel J.
Duque, Cristiane [UNESP]
dc.subject.por.fl_str_mv Early childhood caries
Glucan binding proteins
Imunoglobulin A
S. mutans
topic Early childhood caries
Glucan binding proteins
Imunoglobulin A
S. mutans
description Objective Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC.
publishDate 2016
dc.date.none.fl_str_mv 2016-07-01
2018-12-11T17:02:05Z
2018-12-11T17:02:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.archoralbio.2016.03.006
Archives of Oral Biology, v. 67, p. 22-27.
1879-1506
0003-9969
http://hdl.handle.net/11449/172763
10.1016/j.archoralbio.2016.03.006
2-s2.0-84962277162
2-s2.0-84962277162.pdf
5651874509493617
0000-0002-2575-279X
url http://dx.doi.org/10.1016/j.archoralbio.2016.03.006
http://hdl.handle.net/11449/172763
identifier_str_mv Archives of Oral Biology, v. 67, p. 22-27.
1879-1506
0003-9969
10.1016/j.archoralbio.2016.03.006
2-s2.0-84962277162
2-s2.0-84962277162.pdf
5651874509493617
0000-0002-2575-279X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Archives of Oral Biology
0,752
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22-27
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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