Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.archoralbio.2016.03.006 http://hdl.handle.net/11449/172763 |
Resumo: | Objective Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC. |
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Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhoodEarly childhood cariesGlucan binding proteinsImunoglobulin AS. mutansObjective Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC.UNESP - Univ Estadual Paulista Araçatuba Dental School Department of Pediatric Dentistry and Public Health, R. José Bonifácio, 1193Sao Francisco University Dental School Laboratory of Microbiology and Molecular BiologyUNICAMP- University of Campinas Piracicaba Dental School Department of Oral DiagnosisForsyth Institute Department of Immunology and Infectious DiseaseUNESP - Univ Estadual Paulista Araçatuba Dental School Department of Pediatric Dentistry and Public Health, R. José Bonifácio, 1193Universidade Estadual Paulista (Unesp)Laboratory of Microbiology and Molecular BiologyUniversidade Estadual de Campinas (UNICAMP)Forsyth InstituteColombo, Natália Helena [UNESP]Pereira, Jesse Augusto [UNESP]Da Silva, Márjully Eduardo Rodrigues [UNESP]Ribas, Laís Fernanda Fonseca [UNESP]Parisotto, Thaís ManzanoMattos-Graner, Renata De OliveiraSmith, Daniel J.Duque, Cristiane [UNESP]2018-12-11T17:02:05Z2018-12-11T17:02:05Z2016-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article22-27application/pdfhttp://dx.doi.org/10.1016/j.archoralbio.2016.03.006Archives of Oral Biology, v. 67, p. 22-27.1879-15060003-9969http://hdl.handle.net/11449/17276310.1016/j.archoralbio.2016.03.0062-s2.0-849622771622-s2.0-84962277162.pdf56518745094936170000-0002-2575-279XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Oral Biology0,752info:eu-repo/semantics/openAccess2024-09-19T17:57:24Zoai:repositorio.unesp.br:11449/172763Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T17:57:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood |
title |
Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood |
spellingShingle |
Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood Colombo, Natália Helena [UNESP] Early childhood caries Glucan binding proteins Imunoglobulin A S. mutans |
title_short |
Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood |
title_full |
Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood |
title_fullStr |
Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood |
title_full_unstemmed |
Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood |
title_sort |
Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood |
author |
Colombo, Natália Helena [UNESP] |
author_facet |
Colombo, Natália Helena [UNESP] Pereira, Jesse Augusto [UNESP] Da Silva, Márjully Eduardo Rodrigues [UNESP] Ribas, Laís Fernanda Fonseca [UNESP] Parisotto, Thaís Manzano Mattos-Graner, Renata De Oliveira Smith, Daniel J. Duque, Cristiane [UNESP] |
author_role |
author |
author2 |
Pereira, Jesse Augusto [UNESP] Da Silva, Márjully Eduardo Rodrigues [UNESP] Ribas, Laís Fernanda Fonseca [UNESP] Parisotto, Thaís Manzano Mattos-Graner, Renata De Oliveira Smith, Daniel J. Duque, Cristiane [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Laboratory of Microbiology and Molecular Biology Universidade Estadual de Campinas (UNICAMP) Forsyth Institute |
dc.contributor.author.fl_str_mv |
Colombo, Natália Helena [UNESP] Pereira, Jesse Augusto [UNESP] Da Silva, Márjully Eduardo Rodrigues [UNESP] Ribas, Laís Fernanda Fonseca [UNESP] Parisotto, Thaís Manzano Mattos-Graner, Renata De Oliveira Smith, Daniel J. Duque, Cristiane [UNESP] |
dc.subject.por.fl_str_mv |
Early childhood caries Glucan binding proteins Imunoglobulin A S. mutans |
topic |
Early childhood caries Glucan binding proteins Imunoglobulin A S. mutans |
description |
Objective Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-01 2018-12-11T17:02:05Z 2018-12-11T17:02:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.archoralbio.2016.03.006 Archives of Oral Biology, v. 67, p. 22-27. 1879-1506 0003-9969 http://hdl.handle.net/11449/172763 10.1016/j.archoralbio.2016.03.006 2-s2.0-84962277162 2-s2.0-84962277162.pdf 5651874509493617 0000-0002-2575-279X |
url |
http://dx.doi.org/10.1016/j.archoralbio.2016.03.006 http://hdl.handle.net/11449/172763 |
identifier_str_mv |
Archives of Oral Biology, v. 67, p. 22-27. 1879-1506 0003-9969 10.1016/j.archoralbio.2016.03.006 2-s2.0-84962277162 2-s2.0-84962277162.pdf 5651874509493617 0000-0002-2575-279X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Oral Biology 0,752 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
22-27 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1813546520866193408 |