Adenanthin Is an Efficient Inhibitor of Peroxiredoxins from Pathogens, Inhibits Bacterial Growth, and Potentiates Antibiotic Activities

• Autor(a) principal: Santos, Melina Cardoso dos [UNESP]
• Data de Publicação: 2022
• Outros Autores: Tairum, Carlos Abrunhosa, Cabrera, Vitoria Isabela Montanhero [UNESP], Cauz, Ana Carolina Guimarães, Ribeiro, Luiz Fernando [UNESP], Toledo Junior, José Carlos, Toyama, Marcos Hikari [UNESP], Lago, João Henrique Ghilardi, Brocchi, Marcelo, Netto, Luis Eduardo Soares, Oliveira, Marcos Antonio de [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1021/acs.chemrestox.2c00049; http://hdl.handle.net/11449/241042

The emergence and re-emergence of bacterial strains resistant to multiple drugs represent a global health threat, and the search for novel biological targets is a worldwide concern. AhpC are enzymes involved in bacterial redox homeostasis by metabolizing diverse kinds of hydroperoxides. In pathogenic bacteria, AhpC are related to several functions, as some isoforms are characterized as virulence factors. However, no inhibitor has been systematically evaluated to date. Here we show that the natural ent-kaurane Adenanthin (Adn) efficiently inhibits AhpC and molecular interactions were explored by computer assisted simulations. Additionally, Adn interferes with growth and potentializes the effect of antibiotics (kanamycin and PMBN), positioning Adn as a promising compound to treat infections caused by multiresistant bacterial strains.