Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response

Detalhes bibliográficos
Autor(a) principal: Castro, Almir L. [UNESP]
Data de Publicação: 1983
Outros Autores: Almeida, Eloisa F. [UNESP], Vadenal, Ricardo [UNESP], Lopes, Oswaldo U. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1161/01.hyp.5.6_pt_3.v85
http://hdl.handle.net/11449/223903
Resumo: The role of the central nervous system, in general, and of the hypothalamus, in particular, in the genesis of various forms of experimental hypertension has been the object of increased investigation. Lesions of the dnteroventral area of the third ventricle (AV3V) in rats seem to block the development of various forms of hypertension. In the present experiments, AV3V was kept intact but its connections with the caudal neuroaxis were.severed by means of a curved knife (2 mm radius), stereotaxically placed at the level of the arcuate nucleus. This disconnection, per se, induces poh/dipsia, and a reduction of the pressor effect of i.v.-infused angiotensin II. The interactions of simultaneously performed hypothalamic disconnection (HD) and Goldblatt one-kidney, one clip, (1K1C) or two-kidney, one clip (2K1C) hypertensions was studied. It was found that HD retards and attenuates the development of 1K1C hypertension but does not materially affect the evolution of the 2K1C model. Rats with established 1K1C or 2K1C hypertensions were not affected by HD, whereas rats with chronic HD (4 weeks) showed slight and slow developing hypertension in response to clipping. The possible significance of these results with respect to the neural connections of AV3V is discussed. © 1983 American Heart Association, Inc.
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spelling Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual responseBrain disconnectionCentral nervous systemHypertensionHypothalamus angiotensin IIThe role of the central nervous system, in general, and of the hypothalamus, in particular, in the genesis of various forms of experimental hypertension has been the object of increased investigation. Lesions of the dnteroventral area of the third ventricle (AV3V) in rats seem to block the development of various forms of hypertension. In the present experiments, AV3V was kept intact but its connections with the caudal neuroaxis were.severed by means of a curved knife (2 mm radius), stereotaxically placed at the level of the arcuate nucleus. This disconnection, per se, induces poh/dipsia, and a reduction of the pressor effect of i.v.-infused angiotensin II. The interactions of simultaneously performed hypothalamic disconnection (HD) and Goldblatt one-kidney, one clip, (1K1C) or two-kidney, one clip (2K1C) hypertensions was studied. It was found that HD retards and attenuates the development of 1K1C hypertension but does not materially affect the evolution of the 2K1C model. Rats with established 1K1C or 2K1C hypertensions were not affected by HD, whereas rats with chronic HD (4 weeks) showed slight and slow developing hypertension in response to clipping. The possible significance of these results with respect to the neural connections of AV3V is discussed. © 1983 American Heart Association, Inc.Department of Physiological Sciences Universidade Estadual Paulista, AraçatubaDepartment of Physiology and Biophysics Institute de CiSncias Biome’dicas Universidade de Sao PauloDepartment of Physiological Sciences Universidade Estadual Paulista, AraçatubaUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Castro, Almir L. [UNESP]Almeida, Eloisa F. [UNESP]Vadenal, Ricardo [UNESP]Lopes, Oswaldo U. [UNESP]2022-04-28T19:53:45Z2022-04-28T19:53:45Z1983-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article85-89http://dx.doi.org/10.1161/01.hyp.5.6_pt_3.v85Hypertension, v. 5, n. 6, p. 85-89, 1983.1524-45630194-911Xhttp://hdl.handle.net/11449/22390310.1161/01.hyp.5.6_pt_3.v852-s2.0-0021021721Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengHypertensioninfo:eu-repo/semantics/openAccess2024-09-19T14:03:05Zoai:repositorio.unesp.br:11449/223903Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T14:03:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
title Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
spellingShingle Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
Castro, Almir L. [UNESP]
Brain disconnection
Central nervous system
Hypertension
Hypothalamus angiotensin II
title_short Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
title_full Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
title_fullStr Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
title_full_unstemmed Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
title_sort Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
author Castro, Almir L. [UNESP]
author_facet Castro, Almir L. [UNESP]
Almeida, Eloisa F. [UNESP]
Vadenal, Ricardo [UNESP]
Lopes, Oswaldo U. [UNESP]
author_role author
author2 Almeida, Eloisa F. [UNESP]
Vadenal, Ricardo [UNESP]
Lopes, Oswaldo U. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Castro, Almir L. [UNESP]
Almeida, Eloisa F. [UNESP]
Vadenal, Ricardo [UNESP]
Lopes, Oswaldo U. [UNESP]
dc.subject.por.fl_str_mv Brain disconnection
Central nervous system
Hypertension
Hypothalamus angiotensin II
topic Brain disconnection
Central nervous system
Hypertension
Hypothalamus angiotensin II
description The role of the central nervous system, in general, and of the hypothalamus, in particular, in the genesis of various forms of experimental hypertension has been the object of increased investigation. Lesions of the dnteroventral area of the third ventricle (AV3V) in rats seem to block the development of various forms of hypertension. In the present experiments, AV3V was kept intact but its connections with the caudal neuroaxis were.severed by means of a curved knife (2 mm radius), stereotaxically placed at the level of the arcuate nucleus. This disconnection, per se, induces poh/dipsia, and a reduction of the pressor effect of i.v.-infused angiotensin II. The interactions of simultaneously performed hypothalamic disconnection (HD) and Goldblatt one-kidney, one clip, (1K1C) or two-kidney, one clip (2K1C) hypertensions was studied. It was found that HD retards and attenuates the development of 1K1C hypertension but does not materially affect the evolution of the 2K1C model. Rats with established 1K1C or 2K1C hypertensions were not affected by HD, whereas rats with chronic HD (4 weeks) showed slight and slow developing hypertension in response to clipping. The possible significance of these results with respect to the neural connections of AV3V is discussed. © 1983 American Heart Association, Inc.
publishDate 1983
dc.date.none.fl_str_mv 1983-01-01
2022-04-28T19:53:45Z
2022-04-28T19:53:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1161/01.hyp.5.6_pt_3.v85
Hypertension, v. 5, n. 6, p. 85-89, 1983.
1524-4563
0194-911X
http://hdl.handle.net/11449/223903
10.1161/01.hyp.5.6_pt_3.v85
2-s2.0-0021021721
url http://dx.doi.org/10.1161/01.hyp.5.6_pt_3.v85
http://hdl.handle.net/11449/223903
identifier_str_mv Hypertension, v. 5, n. 6, p. 85-89, 1983.
1524-4563
0194-911X
10.1161/01.hyp.5.6_pt_3.v85
2-s2.0-0021021721
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Hypertension
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 85-89
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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