Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response
Autor(a) principal: | |
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Data de Publicação: | 1983 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1161/01.hyp.5.6_pt_3.v85 http://hdl.handle.net/11449/223903 |
Resumo: | The role of the central nervous system, in general, and of the hypothalamus, in particular, in the genesis of various forms of experimental hypertension has been the object of increased investigation. Lesions of the dnteroventral area of the third ventricle (AV3V) in rats seem to block the development of various forms of hypertension. In the present experiments, AV3V was kept intact but its connections with the caudal neuroaxis were.severed by means of a curved knife (2 mm radius), stereotaxically placed at the level of the arcuate nucleus. This disconnection, per se, induces poh/dipsia, and a reduction of the pressor effect of i.v.-infused angiotensin II. The interactions of simultaneously performed hypothalamic disconnection (HD) and Goldblatt one-kidney, one clip, (1K1C) or two-kidney, one clip (2K1C) hypertensions was studied. It was found that HD retards and attenuates the development of 1K1C hypertension but does not materially affect the evolution of the 2K1C model. Rats with established 1K1C or 2K1C hypertensions were not affected by HD, whereas rats with chronic HD (4 weeks) showed slight and slow developing hypertension in response to clipping. The possible significance of these results with respect to the neural connections of AV3V is discussed. © 1983 American Heart Association, Inc. |
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Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual responseBrain disconnectionCentral nervous systemHypertensionHypothalamus angiotensin IIThe role of the central nervous system, in general, and of the hypothalamus, in particular, in the genesis of various forms of experimental hypertension has been the object of increased investigation. Lesions of the dnteroventral area of the third ventricle (AV3V) in rats seem to block the development of various forms of hypertension. In the present experiments, AV3V was kept intact but its connections with the caudal neuroaxis were.severed by means of a curved knife (2 mm radius), stereotaxically placed at the level of the arcuate nucleus. This disconnection, per se, induces poh/dipsia, and a reduction of the pressor effect of i.v.-infused angiotensin II. The interactions of simultaneously performed hypothalamic disconnection (HD) and Goldblatt one-kidney, one clip, (1K1C) or two-kidney, one clip (2K1C) hypertensions was studied. It was found that HD retards and attenuates the development of 1K1C hypertension but does not materially affect the evolution of the 2K1C model. Rats with established 1K1C or 2K1C hypertensions were not affected by HD, whereas rats with chronic HD (4 weeks) showed slight and slow developing hypertension in response to clipping. The possible significance of these results with respect to the neural connections of AV3V is discussed. © 1983 American Heart Association, Inc.Department of Physiological Sciences Universidade Estadual Paulista, AraçatubaDepartment of Physiology and Biophysics Institute de CiSncias Biome’dicas Universidade de Sao PauloDepartment of Physiological Sciences Universidade Estadual Paulista, AraçatubaUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Castro, Almir L. [UNESP]Almeida, Eloisa F. [UNESP]Vadenal, Ricardo [UNESP]Lopes, Oswaldo U. [UNESP]2022-04-28T19:53:45Z2022-04-28T19:53:45Z1983-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article85-89http://dx.doi.org/10.1161/01.hyp.5.6_pt_3.v85Hypertension, v. 5, n. 6, p. 85-89, 1983.1524-45630194-911Xhttp://hdl.handle.net/11449/22390310.1161/01.hyp.5.6_pt_3.v852-s2.0-0021021721Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengHypertensioninfo:eu-repo/semantics/openAccess2024-09-19T14:03:05Zoai:repositorio.unesp.br:11449/223903Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T14:03:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response |
title |
Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response |
spellingShingle |
Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response Castro, Almir L. [UNESP] Brain disconnection Central nervous system Hypertension Hypothalamus angiotensin II |
title_short |
Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response |
title_full |
Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response |
title_fullStr |
Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response |
title_full_unstemmed |
Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response |
title_sort |
Effects of anterior hypothalamic disconnection on the evolution of goldblatt renal hypertension: A dual response |
author |
Castro, Almir L. [UNESP] |
author_facet |
Castro, Almir L. [UNESP] Almeida, Eloisa F. [UNESP] Vadenal, Ricardo [UNESP] Lopes, Oswaldo U. [UNESP] |
author_role |
author |
author2 |
Almeida, Eloisa F. [UNESP] Vadenal, Ricardo [UNESP] Lopes, Oswaldo U. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Castro, Almir L. [UNESP] Almeida, Eloisa F. [UNESP] Vadenal, Ricardo [UNESP] Lopes, Oswaldo U. [UNESP] |
dc.subject.por.fl_str_mv |
Brain disconnection Central nervous system Hypertension Hypothalamus angiotensin II |
topic |
Brain disconnection Central nervous system Hypertension Hypothalamus angiotensin II |
description |
The role of the central nervous system, in general, and of the hypothalamus, in particular, in the genesis of various forms of experimental hypertension has been the object of increased investigation. Lesions of the dnteroventral area of the third ventricle (AV3V) in rats seem to block the development of various forms of hypertension. In the present experiments, AV3V was kept intact but its connections with the caudal neuroaxis were.severed by means of a curved knife (2 mm radius), stereotaxically placed at the level of the arcuate nucleus. This disconnection, per se, induces poh/dipsia, and a reduction of the pressor effect of i.v.-infused angiotensin II. The interactions of simultaneously performed hypothalamic disconnection (HD) and Goldblatt one-kidney, one clip, (1K1C) or two-kidney, one clip (2K1C) hypertensions was studied. It was found that HD retards and attenuates the development of 1K1C hypertension but does not materially affect the evolution of the 2K1C model. Rats with established 1K1C or 2K1C hypertensions were not affected by HD, whereas rats with chronic HD (4 weeks) showed slight and slow developing hypertension in response to clipping. The possible significance of these results with respect to the neural connections of AV3V is discussed. © 1983 American Heart Association, Inc. |
publishDate |
1983 |
dc.date.none.fl_str_mv |
1983-01-01 2022-04-28T19:53:45Z 2022-04-28T19:53:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1161/01.hyp.5.6_pt_3.v85 Hypertension, v. 5, n. 6, p. 85-89, 1983. 1524-4563 0194-911X http://hdl.handle.net/11449/223903 10.1161/01.hyp.5.6_pt_3.v85 2-s2.0-0021021721 |
url |
http://dx.doi.org/10.1161/01.hyp.5.6_pt_3.v85 http://hdl.handle.net/11449/223903 |
identifier_str_mv |
Hypertension, v. 5, n. 6, p. 85-89, 1983. 1524-4563 0194-911X 10.1161/01.hyp.5.6_pt_3.v85 2-s2.0-0021021721 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Hypertension |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
85-89 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1813546500783865856 |