Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitus

Detalhes bibliográficos
Autor(a) principal: Sena, Erika M A B.
Data de Publicação: 2022
Outros Autores: Silva, Dianna V L., Américo, Madileine F., Nascimento, Jhony W G., Miranda, José R A. [UNESP], Corá, Luciana A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0004-2803.202202000-42
http://hdl.handle.net/11449/240489
Resumo: Background – Gastrointestinal (GI) motility disorders in type 2 diabetes mellitus (T2DM) are common. However, the endpoints in well-controlled T2DM in elderly patients are barely understood. Objective – To evaluate GI transit and gastric myoelectric activity in elderly patients with T2DM who were undergoing treatment with metformin and to compare them with non-diabetic healthy controls. Methods – A total of thirty participants were enrolled in this study: young non-diabetic (n=10), elderly non-diabetic controls (n=10), and patients with T2DM managed with met-formin (n=10). After fasting overnight, the participants ingested a standard meal and magnetic markers for non-invasive monitoring of GI transit and gastric contractility using the alternating current biosusceptometry and electrogastrography techniques. Results – Mean gastric emptying time, mean colon arrival time, and mean intestinal transit time were determined. There were no significant differences between the groups and in the parameters evaluated (P>0.05). The frequency and amplitude of gastric myoelectric activity were not different between groups; however, abnormal rhythmic index and the half-bandwidth were slightly higher for both elderly diabetic and non-diabetic groups compared with the young adults (P<0.01 and P<0.05, respectively). Conclusion – Our study showed unaltered gastric emptying and intestinal transit in T2DM patients with good glycemic control, and suggest changes in the gastric electrical activity can be a part of aging.
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spelling Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitusMotilidade gastrintestinal em pacientes idosos com diabetes mellitus tipo 2 bem controlado.Elderlygastrointestinal motilityglycemic controlmetformintype 2 diabetes mellitusBackground – Gastrointestinal (GI) motility disorders in type 2 diabetes mellitus (T2DM) are common. However, the endpoints in well-controlled T2DM in elderly patients are barely understood. Objective – To evaluate GI transit and gastric myoelectric activity in elderly patients with T2DM who were undergoing treatment with metformin and to compare them with non-diabetic healthy controls. Methods – A total of thirty participants were enrolled in this study: young non-diabetic (n=10), elderly non-diabetic controls (n=10), and patients with T2DM managed with met-formin (n=10). After fasting overnight, the participants ingested a standard meal and magnetic markers for non-invasive monitoring of GI transit and gastric contractility using the alternating current biosusceptometry and electrogastrography techniques. Results – Mean gastric emptying time, mean colon arrival time, and mean intestinal transit time were determined. There were no significant differences between the groups and in the parameters evaluated (P>0.05). The frequency and amplitude of gastric myoelectric activity were not different between groups; however, abnormal rhythmic index and the half-bandwidth were slightly higher for both elderly diabetic and non-diabetic groups compared with the young adults (P<0.01 and P<0.05, respectively). Conclusion – Our study showed unaltered gastric emptying and intestinal transit in T2DM patients with good glycemic control, and suggest changes in the gastric electrical activity can be a part of aging.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de AlagoasUniversidade Federal de Alagoas Hospital Universitário Professor Alberto Antunes, ALUniversidade Estadual de Ciências da Saúde de Alagoas Centro de Ciências Integradoras, ALUniversidade Federal do Mato Grosso Instituto de Ciências Biológicas e da Saúde, MTUniversidade Federal de Alagoas Rede Nordeste de Biotecnologia, ALUniversidade Estadual Paulista Departamento de Física e Biofísica, SPUniversidade Estadual Paulista Departamento de Física e Biofísica, SPHospital Universitário Professor Alberto AntunesCentro de Ciências IntegradorasInstituto de Ciências Biológicas e da SaúdeRede Nordeste de BiotecnologiaUniversidade Estadual Paulista (UNESP)Sena, Erika M A B.Silva, Dianna V L.Américo, Madileine F.Nascimento, Jhony W G.Miranda, José R A. [UNESP]Corá, Luciana A.2023-03-01T20:19:23Z2023-03-01T20:19:23Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article231-237http://dx.doi.org/10.1590/S0004-2803.202202000-42Arquivos de Gastroenterologia, v. 59, n. 2, p. 231-237, 2022.1678-42190004-2803http://hdl.handle.net/11449/24048910.1590/S0004-2803.202202000-422-s2.0-85134435166Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos de Gastroenterologiainfo:eu-repo/semantics/openAccess2023-03-01T20:19:24Zoai:repositorio.unesp.br:11449/240489Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:48:38.818874Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitus
Motilidade gastrintestinal em pacientes idosos com diabetes mellitus tipo 2 bem controlado.
title Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitus
spellingShingle Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitus
Sena, Erika M A B.
Elderly
gastrointestinal motility
glycemic control
metformin
type 2 diabetes mellitus
title_short Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitus
title_full Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitus
title_fullStr Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitus
title_full_unstemmed Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitus
title_sort Gastrointestinal motility in elderly patients with well-controlled type 2 diabetes mellitus
author Sena, Erika M A B.
author_facet Sena, Erika M A B.
Silva, Dianna V L.
Américo, Madileine F.
Nascimento, Jhony W G.
Miranda, José R A. [UNESP]
Corá, Luciana A.
author_role author
author2 Silva, Dianna V L.
Américo, Madileine F.
Nascimento, Jhony W G.
Miranda, José R A. [UNESP]
Corá, Luciana A.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Hospital Universitário Professor Alberto Antunes
Centro de Ciências Integradoras
Instituto de Ciências Biológicas e da Saúde
Rede Nordeste de Biotecnologia
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Sena, Erika M A B.
Silva, Dianna V L.
Américo, Madileine F.
Nascimento, Jhony W G.
Miranda, José R A. [UNESP]
Corá, Luciana A.
dc.subject.por.fl_str_mv Elderly
gastrointestinal motility
glycemic control
metformin
type 2 diabetes mellitus
topic Elderly
gastrointestinal motility
glycemic control
metformin
type 2 diabetes mellitus
description Background – Gastrointestinal (GI) motility disorders in type 2 diabetes mellitus (T2DM) are common. However, the endpoints in well-controlled T2DM in elderly patients are barely understood. Objective – To evaluate GI transit and gastric myoelectric activity in elderly patients with T2DM who were undergoing treatment with metformin and to compare them with non-diabetic healthy controls. Methods – A total of thirty participants were enrolled in this study: young non-diabetic (n=10), elderly non-diabetic controls (n=10), and patients with T2DM managed with met-formin (n=10). After fasting overnight, the participants ingested a standard meal and magnetic markers for non-invasive monitoring of GI transit and gastric contractility using the alternating current biosusceptometry and electrogastrography techniques. Results – Mean gastric emptying time, mean colon arrival time, and mean intestinal transit time were determined. There were no significant differences between the groups and in the parameters evaluated (P>0.05). The frequency and amplitude of gastric myoelectric activity were not different between groups; however, abnormal rhythmic index and the half-bandwidth were slightly higher for both elderly diabetic and non-diabetic groups compared with the young adults (P<0.01 and P<0.05, respectively). Conclusion – Our study showed unaltered gastric emptying and intestinal transit in T2DM patients with good glycemic control, and suggest changes in the gastric electrical activity can be a part of aging.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-01T20:19:23Z
2023-03-01T20:19:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-2803.202202000-42
Arquivos de Gastroenterologia, v. 59, n. 2, p. 231-237, 2022.
1678-4219
0004-2803
http://hdl.handle.net/11449/240489
10.1590/S0004-2803.202202000-42
2-s2.0-85134435166
url http://dx.doi.org/10.1590/S0004-2803.202202000-42
http://hdl.handle.net/11449/240489
identifier_str_mv Arquivos de Gastroenterologia, v. 59, n. 2, p. 231-237, 2022.
1678-4219
0004-2803
10.1590/S0004-2803.202202000-42
2-s2.0-85134435166
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Gastroenterologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 231-237
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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