Oral colonization by yeasts in hiv-positive patients in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0036-46652012000100004 http://hdl.handle.net/11449/22616 |
Resumo: | Introduction: In HIV-infected patients, colonization of the oral cavity by potential pathogenic yeast may lead to development of systemic fungemia. We evaluated the prevalence of yeast in the oral cavity of Brazilian HIV-positive patients and verified whether or not the species characterized were enzymatically active. Furthermore, the species identified were tested for their susceptibility to antifungal treatment. Methods: Patient saliva and oropharyngeal candidiasis samples were collected from 60 seropositive HIV patients and identified by the API20C system. Enzymatic activity was evaluated by the production of proteinase and phospholipase. Susceptibility to antifungal treatments were determined using the broth microdilution method. Results: the most commonly isolated species were C. albicans (51.56%) followed by non-albicans Candida species (43.73%), Trichosporon mucoides (3.12%) and Kodamaea ohmeri (1.56%). Oral colonization by association of different species was observed in 42% of the patients. Enzymatic activity was verified in most of species isolated, except for C. glabrata, C. lusitaniae and C. guilliermondii. Resistance to Fluconazole and Amphotericin B was observed in isolates of C. albicans, C. glabrata, C. parapsilosis, C. krusei, and K. ohmeri. Conclusion: HIV-positive patients are orally colonized by single or multiple species of yeast that are occasionally resistant to Fluconazole or Amphotericin B. |
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Oral colonization by yeasts in hiv-positive patients in BrazilAcquired immunodeficiency syndromeCandidaTrichosporon mucoidesKodamaea ohmeriColonizationIntroduction: In HIV-infected patients, colonization of the oral cavity by potential pathogenic yeast may lead to development of systemic fungemia. We evaluated the prevalence of yeast in the oral cavity of Brazilian HIV-positive patients and verified whether or not the species characterized were enzymatically active. Furthermore, the species identified were tested for their susceptibility to antifungal treatment. Methods: Patient saliva and oropharyngeal candidiasis samples were collected from 60 seropositive HIV patients and identified by the API20C system. Enzymatic activity was evaluated by the production of proteinase and phospholipase. Susceptibility to antifungal treatments were determined using the broth microdilution method. Results: the most commonly isolated species were C. albicans (51.56%) followed by non-albicans Candida species (43.73%), Trichosporon mucoides (3.12%) and Kodamaea ohmeri (1.56%). Oral colonization by association of different species was observed in 42% of the patients. Enzymatic activity was verified in most of species isolated, except for C. glabrata, C. lusitaniae and C. guilliermondii. Resistance to Fluconazole and Amphotericin B was observed in isolates of C. albicans, C. glabrata, C. parapsilosis, C. krusei, and K. ohmeri. Conclusion: HIV-positive patients are orally colonized by single or multiple species of yeast that are occasionally resistant to Fluconazole or Amphotericin B.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Pró-Reitoria de Pesquisa da UNESP (PROPe UNESP)Univ Estadual Paulista UNESP, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP, BrazilEmilio Ribas Inst Infectol, BR-01246900 São Paulo, BrazilUniv Estadual Paulista UNESP, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP, BrazilFAPESP: 2009/52283-0Inst Medicina Tropical São PauloUniversidade Estadual Paulista (Unesp)Instituto de Infectologia Emílio RibasJunqueira, Juliana Campos [UNESP]Vilela, Simone F. G. [UNESP]Rossoni, Rodnei D. [UNESP]Barbosa, Junia O. [UNESP]Costa, Anna Carolina B. P. [UNESP]Rasteiro, Vanessa M. C. [UNESP]Suleiman, Jamal M. A. H.Jorge, Antonio Olavo Cardoso [UNESP]2014-05-20T14:04:28Z2014-05-20T14:04:28Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17-24application/pdfhttp://dx.doi.org/10.1590/S0036-46652012000100004Revista do Instituto de Medicina Tropical de São Paulo. São Paulo: Inst Medicina Tropical São Paulo, v. 54, n. 1, p. 17-24, 2012.0036-4665http://hdl.handle.net/11449/2261610.1590/S0036-46652012000100004S0036-46652012000100004WOS:000300796100004S0036-46652012000100004.pdf032202054105590016646883578042990053567153623569Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista do Instituto de Medicina Tropical de São Paulo1.4890,669info:eu-repo/semantics/openAccess2023-12-18T06:16:56Zoai:repositorio.unesp.br:11449/22616Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-18T06:16:56Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Oral colonization by yeasts in hiv-positive patients in Brazil |
title |
Oral colonization by yeasts in hiv-positive patients in Brazil |
spellingShingle |
Oral colonization by yeasts in hiv-positive patients in Brazil Junqueira, Juliana Campos [UNESP] Acquired immunodeficiency syndrome Candida Trichosporon mucoides Kodamaea ohmeri Colonization |
title_short |
Oral colonization by yeasts in hiv-positive patients in Brazil |
title_full |
Oral colonization by yeasts in hiv-positive patients in Brazil |
title_fullStr |
Oral colonization by yeasts in hiv-positive patients in Brazil |
title_full_unstemmed |
Oral colonization by yeasts in hiv-positive patients in Brazil |
title_sort |
Oral colonization by yeasts in hiv-positive patients in Brazil |
author |
Junqueira, Juliana Campos [UNESP] |
author_facet |
Junqueira, Juliana Campos [UNESP] Vilela, Simone F. G. [UNESP] Rossoni, Rodnei D. [UNESP] Barbosa, Junia O. [UNESP] Costa, Anna Carolina B. P. [UNESP] Rasteiro, Vanessa M. C. [UNESP] Suleiman, Jamal M. A. H. Jorge, Antonio Olavo Cardoso [UNESP] |
author_role |
author |
author2 |
Vilela, Simone F. G. [UNESP] Rossoni, Rodnei D. [UNESP] Barbosa, Junia O. [UNESP] Costa, Anna Carolina B. P. [UNESP] Rasteiro, Vanessa M. C. [UNESP] Suleiman, Jamal M. A. H. Jorge, Antonio Olavo Cardoso [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Instituto de Infectologia Emílio Ribas |
dc.contributor.author.fl_str_mv |
Junqueira, Juliana Campos [UNESP] Vilela, Simone F. G. [UNESP] Rossoni, Rodnei D. [UNESP] Barbosa, Junia O. [UNESP] Costa, Anna Carolina B. P. [UNESP] Rasteiro, Vanessa M. C. [UNESP] Suleiman, Jamal M. A. H. Jorge, Antonio Olavo Cardoso [UNESP] |
dc.subject.por.fl_str_mv |
Acquired immunodeficiency syndrome Candida Trichosporon mucoides Kodamaea ohmeri Colonization |
topic |
Acquired immunodeficiency syndrome Candida Trichosporon mucoides Kodamaea ohmeri Colonization |
description |
Introduction: In HIV-infected patients, colonization of the oral cavity by potential pathogenic yeast may lead to development of systemic fungemia. We evaluated the prevalence of yeast in the oral cavity of Brazilian HIV-positive patients and verified whether or not the species characterized were enzymatically active. Furthermore, the species identified were tested for their susceptibility to antifungal treatment. Methods: Patient saliva and oropharyngeal candidiasis samples were collected from 60 seropositive HIV patients and identified by the API20C system. Enzymatic activity was evaluated by the production of proteinase and phospholipase. Susceptibility to antifungal treatments were determined using the broth microdilution method. Results: the most commonly isolated species were C. albicans (51.56%) followed by non-albicans Candida species (43.73%), Trichosporon mucoides (3.12%) and Kodamaea ohmeri (1.56%). Oral colonization by association of different species was observed in 42% of the patients. Enzymatic activity was verified in most of species isolated, except for C. glabrata, C. lusitaniae and C. guilliermondii. Resistance to Fluconazole and Amphotericin B was observed in isolates of C. albicans, C. glabrata, C. parapsilosis, C. krusei, and K. ohmeri. Conclusion: HIV-positive patients are orally colonized by single or multiple species of yeast that are occasionally resistant to Fluconazole or Amphotericin B. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2014-05-20T14:04:28Z 2014-05-20T14:04:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0036-46652012000100004 Revista do Instituto de Medicina Tropical de São Paulo. São Paulo: Inst Medicina Tropical São Paulo, v. 54, n. 1, p. 17-24, 2012. 0036-4665 http://hdl.handle.net/11449/22616 10.1590/S0036-46652012000100004 S0036-46652012000100004 WOS:000300796100004 S0036-46652012000100004.pdf 0322020541055900 1664688357804299 0053567153623569 |
url |
http://dx.doi.org/10.1590/S0036-46652012000100004 http://hdl.handle.net/11449/22616 |
identifier_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo. São Paulo: Inst Medicina Tropical São Paulo, v. 54, n. 1, p. 17-24, 2012. 0036-4665 10.1590/S0036-46652012000100004 S0036-46652012000100004 WOS:000300796100004 S0036-46652012000100004.pdf 0322020541055900 1664688357804299 0053567153623569 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo 1.489 0,669 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
17-24 application/pdf |
dc.publisher.none.fl_str_mv |
Inst Medicina Tropical São Paulo |
publisher.none.fl_str_mv |
Inst Medicina Tropical São Paulo |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965326062911488 |