Chemical composition and antiproliferative, antioxidant and trypanocidal activities of the fruits from Campomanesia xanthocarpa (Mart.) O. Berg (Myrtaceae)

• Autor(a) principal: Salmazzo, Gustavo Ruivo
• Data de Publicação: 2019
• Outros Autores: Verdan, Maria Helena, Silva, Flávia [UNESP], Cicarelli, Regina Maria [UNESP], Mota, Jonas da Silva, Salvador, Marcos José, de Carvalho, João Ernesto, Cardoso, Cláudia Andrea Lima
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1080/14786419.2019.1607333; http://hdl.handle.net/11449/187686
• topic: Campomanesia xanthocarpa; chalcones; flavanones; guavira; Trypanossoma cruzi

Chemical investigation of the extracts of the fruits from Campomanesia xanthocarpa resulted in the isolation of six known compounds identified by NMR and comparison with literature data (2′,4′-dihydroxy-5′-methyl-6′-methoxychalcone (1), 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone (2), 2′-hydroxy-3′-methyl-4′,6′-dimethoxychalcone (3), 2′,6′-dihydroxy-3′-methyl-4′-methoxychalcone (4), 5-hydroxy-7-methoxy-8-methylflavanone (5) and 7-hydroxy-5-methoxy-6-methylflavanone (6)). The considerable antioxidant capacity of the extracts was demonstrated by ORAC-FL and DPPH tests. The antiproliferative assay of the extracts and 5 was done in vitro, against many different cancer cell lines besides a healthy one. The extracts presented low cytotoxicity and the substance demonstrated promising results against all the cancer cell lines tested, with IC 50 values ranging from 4.75 to 45.81 µmol L −1 . The in vitro trypanocidal activity was evaluated against the epimastigote form of the Y strain of Trypanosoma cruzi and an improvement in the activity of the substances 2 (221.81 µmol L −1 ) and 5 (61.87 µmol L −1 ) was observed regarding the values obtained for the extracts.