Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats

Detalhes bibliográficos
Autor(a) principal: Minicucci, Marcos Ferreira [UNESP]
Data de Publicação: 2011
Outros Autores: Gaiolla, Paula Schmidt Azevedo [UNESP], Santos, Daniel F. B. [UNESP], Polegato, Bertha Furlan [UNESP], Santos, Priscila P. [UNESP], Okoshi, Katashi [UNESP], Paiva, Sergio Alberto Rupp de [UNESP], Zornoff, Leonardo Antonio Mamede [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0066-782X2011005000117
http://hdl.handle.net/11449/72879
Resumo: Background: The prediction of the ventricular remodeling process after acute myocardial infarction (AMI) may have important clinical implications. Objetive: To analyze echocardiographic variables predictors of remodeling in the infarction model in rats. Methods: The animals underwent echocardiography in two moments, five days and three months after infarction (AMI group) or sham surgery (control group). Linear regression was used to identify the echocardiographic variables on the fifth day after the infarction, which were predictive of remodeling after three months of coronary occlusion. We considered as a criterion of remodeling in this study, the values of left ventricular diastolic diameter (LVDD) after three months of infarction. Results: The infarction induced increase in the left chambers, associated with changes in systolic and diastolic functions. The variables body weight, left ventricular wall stress index (LVWSI), systolic area (SA), diastolic area (DA), LVDD, left ventricular systolic diameter (LVSD), fractional area change (FAC), ejection fraction (EF), fractional shortening (%Short), posterior wall shortening velocity (PWSV) and infarct size assessed five days after infarction were predictors of LVDD after three months. At the multivariate regression analysis, we included the size of infarction, the LVWSI and PWSV. The LVWSI (coefficient: 4.402, standard error: 2.221, p = 0.05), but not the size of infarction and PWSV, was a predictor of remodeling after three months of infarction. Conclusion: LVPSI was an independent predictor of remodeling three months after the myocardial infarction and could be included in the clinical stratification after the coronary occlusion.
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spelling Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in ratsEchocardiographyMyocardial infarctionRatsVentricular remodelingacute heart infarctionanimal cellanimal experimentanimal modelanimal tissuebody weightcontrolled studyechocardiographyheart ejection fractionheart infarction sizeheart ventricle remodelingmalenonhumanratAnimalsDisease Models, AnimalMaleMyocardial InfarctionRats, WistarTime FactorsVentricular Dysfunction, LeftVentricular RemodelingBackground: The prediction of the ventricular remodeling process after acute myocardial infarction (AMI) may have important clinical implications. Objetive: To analyze echocardiographic variables predictors of remodeling in the infarction model in rats. Methods: The animals underwent echocardiography in two moments, five days and three months after infarction (AMI group) or sham surgery (control group). Linear regression was used to identify the echocardiographic variables on the fifth day after the infarction, which were predictive of remodeling after three months of coronary occlusion. We considered as a criterion of remodeling in this study, the values of left ventricular diastolic diameter (LVDD) after three months of infarction. Results: The infarction induced increase in the left chambers, associated with changes in systolic and diastolic functions. The variables body weight, left ventricular wall stress index (LVWSI), systolic area (SA), diastolic area (DA), LVDD, left ventricular systolic diameter (LVSD), fractional area change (FAC), ejection fraction (EF), fractional shortening (%Short), posterior wall shortening velocity (PWSV) and infarct size assessed five days after infarction were predictors of LVDD after three months. At the multivariate regression analysis, we included the size of infarction, the LVWSI and PWSV. The LVWSI (coefficient: 4.402, standard error: 2.221, p = 0.05), but not the size of infarction and PWSV, was a predictor of remodeling after three months of infarction. Conclusion: LVPSI was an independent predictor of remodeling three months after the myocardial infarction and could be included in the clinical stratification after the coronary occlusion.Faculdade de Medicina de Botucatu, Botucatu, SPFaculdade de Medicina de Botucatu, Botucatu, SPUniversidade Estadual Paulista (Unesp)Minicucci, Marcos Ferreira [UNESP]Gaiolla, Paula Schmidt Azevedo [UNESP]Santos, Daniel F. B. [UNESP]Polegato, Bertha Furlan [UNESP]Santos, Priscila P. [UNESP]Okoshi, Katashi [UNESP]Paiva, Sergio Alberto Rupp de [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]2014-05-27T11:26:15Z2014-05-27T11:26:15Z2011-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article502-506application/pdfhttp://dx.doi.org/10.1590/S0066-782X2011005000117Arquivos Brasileiros de Cardiologia, v. 97, n. 6, p. 502-506, 2011.0066-782X1678-4170http://hdl.handle.net/11449/7287910.1590/S0066-782X2011005000117S0066-782X20110050001172-s2.0-848563582422-s2.0-84856358242.pdf15909715763094205016839015394547121314080140264774387040344716730000-0002-5843-6232Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2024-08-14T17:22:14Zoai:repositorio.unesp.br:11449/72879Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
title Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
spellingShingle Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
Minicucci, Marcos Ferreira [UNESP]
Echocardiography
Myocardial infarction
Rats
Ventricular remodeling
acute heart infarction
animal cell
animal experiment
animal model
animal tissue
body weight
controlled study
echocardiography
heart ejection fraction
heart infarction size
heart ventricle remodeling
male
nonhuman
rat
Animals
Disease Models, Animal
Male
Myocardial Infarction
Rats, Wistar
Time Factors
Ventricular Dysfunction, Left
Ventricular Remodeling
title_short Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
title_full Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
title_fullStr Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
title_full_unstemmed Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
title_sort Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
author Minicucci, Marcos Ferreira [UNESP]
author_facet Minicucci, Marcos Ferreira [UNESP]
Gaiolla, Paula Schmidt Azevedo [UNESP]
Santos, Daniel F. B. [UNESP]
Polegato, Bertha Furlan [UNESP]
Santos, Priscila P. [UNESP]
Okoshi, Katashi [UNESP]
Paiva, Sergio Alberto Rupp de [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
author_role author
author2 Gaiolla, Paula Schmidt Azevedo [UNESP]
Santos, Daniel F. B. [UNESP]
Polegato, Bertha Furlan [UNESP]
Santos, Priscila P. [UNESP]
Okoshi, Katashi [UNESP]
Paiva, Sergio Alberto Rupp de [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Minicucci, Marcos Ferreira [UNESP]
Gaiolla, Paula Schmidt Azevedo [UNESP]
Santos, Daniel F. B. [UNESP]
Polegato, Bertha Furlan [UNESP]
Santos, Priscila P. [UNESP]
Okoshi, Katashi [UNESP]
Paiva, Sergio Alberto Rupp de [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
dc.subject.por.fl_str_mv Echocardiography
Myocardial infarction
Rats
Ventricular remodeling
acute heart infarction
animal cell
animal experiment
animal model
animal tissue
body weight
controlled study
echocardiography
heart ejection fraction
heart infarction size
heart ventricle remodeling
male
nonhuman
rat
Animals
Disease Models, Animal
Male
Myocardial Infarction
Rats, Wistar
Time Factors
Ventricular Dysfunction, Left
Ventricular Remodeling
topic Echocardiography
Myocardial infarction
Rats
Ventricular remodeling
acute heart infarction
animal cell
animal experiment
animal model
animal tissue
body weight
controlled study
echocardiography
heart ejection fraction
heart infarction size
heart ventricle remodeling
male
nonhuman
rat
Animals
Disease Models, Animal
Male
Myocardial Infarction
Rats, Wistar
Time Factors
Ventricular Dysfunction, Left
Ventricular Remodeling
description Background: The prediction of the ventricular remodeling process after acute myocardial infarction (AMI) may have important clinical implications. Objetive: To analyze echocardiographic variables predictors of remodeling in the infarction model in rats. Methods: The animals underwent echocardiography in two moments, five days and three months after infarction (AMI group) or sham surgery (control group). Linear regression was used to identify the echocardiographic variables on the fifth day after the infarction, which were predictive of remodeling after three months of coronary occlusion. We considered as a criterion of remodeling in this study, the values of left ventricular diastolic diameter (LVDD) after three months of infarction. Results: The infarction induced increase in the left chambers, associated with changes in systolic and diastolic functions. The variables body weight, left ventricular wall stress index (LVWSI), systolic area (SA), diastolic area (DA), LVDD, left ventricular systolic diameter (LVSD), fractional area change (FAC), ejection fraction (EF), fractional shortening (%Short), posterior wall shortening velocity (PWSV) and infarct size assessed five days after infarction were predictors of LVDD after three months. At the multivariate regression analysis, we included the size of infarction, the LVWSI and PWSV. The LVWSI (coefficient: 4.402, standard error: 2.221, p = 0.05), but not the size of infarction and PWSV, was a predictor of remodeling after three months of infarction. Conclusion: LVPSI was an independent predictor of remodeling three months after the myocardial infarction and could be included in the clinical stratification after the coronary occlusion.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
2014-05-27T11:26:15Z
2014-05-27T11:26:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0066-782X2011005000117
Arquivos Brasileiros de Cardiologia, v. 97, n. 6, p. 502-506, 2011.
0066-782X
1678-4170
http://hdl.handle.net/11449/72879
10.1590/S0066-782X2011005000117
S0066-782X2011005000117
2-s2.0-84856358242
2-s2.0-84856358242.pdf
1590971576309420
5016839015394547
1213140801402647
7438704034471673
0000-0002-5843-6232
url http://dx.doi.org/10.1590/S0066-782X2011005000117
http://hdl.handle.net/11449/72879
identifier_str_mv Arquivos Brasileiros de Cardiologia, v. 97, n. 6, p. 502-506, 2011.
0066-782X
1678-4170
10.1590/S0066-782X2011005000117
S0066-782X2011005000117
2-s2.0-84856358242
2-s2.0-84856358242.pdf
1590971576309420
5016839015394547
1213140801402647
7438704034471673
0000-0002-5843-6232
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Cardiologia
1.318
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 502-506
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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