Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0066-782X2011005000117 http://hdl.handle.net/11449/72879 |
Resumo: | Background: The prediction of the ventricular remodeling process after acute myocardial infarction (AMI) may have important clinical implications. Objetive: To analyze echocardiographic variables predictors of remodeling in the infarction model in rats. Methods: The animals underwent echocardiography in two moments, five days and three months after infarction (AMI group) or sham surgery (control group). Linear regression was used to identify the echocardiographic variables on the fifth day after the infarction, which were predictive of remodeling after three months of coronary occlusion. We considered as a criterion of remodeling in this study, the values of left ventricular diastolic diameter (LVDD) after three months of infarction. Results: The infarction induced increase in the left chambers, associated with changes in systolic and diastolic functions. The variables body weight, left ventricular wall stress index (LVWSI), systolic area (SA), diastolic area (DA), LVDD, left ventricular systolic diameter (LVSD), fractional area change (FAC), ejection fraction (EF), fractional shortening (%Short), posterior wall shortening velocity (PWSV) and infarct size assessed five days after infarction were predictors of LVDD after three months. At the multivariate regression analysis, we included the size of infarction, the LVWSI and PWSV. The LVWSI (coefficient: 4.402, standard error: 2.221, p = 0.05), but not the size of infarction and PWSV, was a predictor of remodeling after three months of infarction. Conclusion: LVPSI was an independent predictor of remodeling three months after the myocardial infarction and could be included in the clinical stratification after the coronary occlusion. |
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Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in ratsEchocardiographyMyocardial infarctionRatsVentricular remodelingacute heart infarctionanimal cellanimal experimentanimal modelanimal tissuebody weightcontrolled studyechocardiographyheart ejection fractionheart infarction sizeheart ventricle remodelingmalenonhumanratAnimalsDisease Models, AnimalMaleMyocardial InfarctionRats, WistarTime FactorsVentricular Dysfunction, LeftVentricular RemodelingBackground: The prediction of the ventricular remodeling process after acute myocardial infarction (AMI) may have important clinical implications. Objetive: To analyze echocardiographic variables predictors of remodeling in the infarction model in rats. Methods: The animals underwent echocardiography in two moments, five days and three months after infarction (AMI group) or sham surgery (control group). Linear regression was used to identify the echocardiographic variables on the fifth day after the infarction, which were predictive of remodeling after three months of coronary occlusion. We considered as a criterion of remodeling in this study, the values of left ventricular diastolic diameter (LVDD) after three months of infarction. Results: The infarction induced increase in the left chambers, associated with changes in systolic and diastolic functions. The variables body weight, left ventricular wall stress index (LVWSI), systolic area (SA), diastolic area (DA), LVDD, left ventricular systolic diameter (LVSD), fractional area change (FAC), ejection fraction (EF), fractional shortening (%Short), posterior wall shortening velocity (PWSV) and infarct size assessed five days after infarction were predictors of LVDD after three months. At the multivariate regression analysis, we included the size of infarction, the LVWSI and PWSV. The LVWSI (coefficient: 4.402, standard error: 2.221, p = 0.05), but not the size of infarction and PWSV, was a predictor of remodeling after three months of infarction. Conclusion: LVPSI was an independent predictor of remodeling three months after the myocardial infarction and could be included in the clinical stratification after the coronary occlusion.Faculdade de Medicina de Botucatu, Botucatu, SPFaculdade de Medicina de Botucatu, Botucatu, SPUniversidade Estadual Paulista (Unesp)Minicucci, Marcos Ferreira [UNESP]Gaiolla, Paula Schmidt Azevedo [UNESP]Santos, Daniel F. B. [UNESP]Polegato, Bertha Furlan [UNESP]Santos, Priscila P. [UNESP]Okoshi, Katashi [UNESP]Paiva, Sergio Alberto Rupp de [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]2014-05-27T11:26:15Z2014-05-27T11:26:15Z2011-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article502-506application/pdfhttp://dx.doi.org/10.1590/S0066-782X2011005000117Arquivos Brasileiros de Cardiologia, v. 97, n. 6, p. 502-506, 2011.0066-782X1678-4170http://hdl.handle.net/11449/7287910.1590/S0066-782X2011005000117S0066-782X20110050001172-s2.0-848563582422-s2.0-84856358242.pdf15909715763094205016839015394547121314080140264774387040344716730000-0002-5843-6232Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2024-08-14T17:22:14Zoai:repositorio.unesp.br:11449/72879Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats |
title |
Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats |
spellingShingle |
Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats Minicucci, Marcos Ferreira [UNESP] Echocardiography Myocardial infarction Rats Ventricular remodeling acute heart infarction animal cell animal experiment animal model animal tissue body weight controlled study echocardiography heart ejection fraction heart infarction size heart ventricle remodeling male nonhuman rat Animals Disease Models, Animal Male Myocardial Infarction Rats, Wistar Time Factors Ventricular Dysfunction, Left Ventricular Remodeling |
title_short |
Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats |
title_full |
Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats |
title_fullStr |
Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats |
title_full_unstemmed |
Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats |
title_sort |
Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats |
author |
Minicucci, Marcos Ferreira [UNESP] |
author_facet |
Minicucci, Marcos Ferreira [UNESP] Gaiolla, Paula Schmidt Azevedo [UNESP] Santos, Daniel F. B. [UNESP] Polegato, Bertha Furlan [UNESP] Santos, Priscila P. [UNESP] Okoshi, Katashi [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] |
author_role |
author |
author2 |
Gaiolla, Paula Schmidt Azevedo [UNESP] Santos, Daniel F. B. [UNESP] Polegato, Bertha Furlan [UNESP] Santos, Priscila P. [UNESP] Okoshi, Katashi [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Minicucci, Marcos Ferreira [UNESP] Gaiolla, Paula Schmidt Azevedo [UNESP] Santos, Daniel F. B. [UNESP] Polegato, Bertha Furlan [UNESP] Santos, Priscila P. [UNESP] Okoshi, Katashi [UNESP] Paiva, Sergio Alberto Rupp de [UNESP] Zornoff, Leonardo Antonio Mamede [UNESP] |
dc.subject.por.fl_str_mv |
Echocardiography Myocardial infarction Rats Ventricular remodeling acute heart infarction animal cell animal experiment animal model animal tissue body weight controlled study echocardiography heart ejection fraction heart infarction size heart ventricle remodeling male nonhuman rat Animals Disease Models, Animal Male Myocardial Infarction Rats, Wistar Time Factors Ventricular Dysfunction, Left Ventricular Remodeling |
topic |
Echocardiography Myocardial infarction Rats Ventricular remodeling acute heart infarction animal cell animal experiment animal model animal tissue body weight controlled study echocardiography heart ejection fraction heart infarction size heart ventricle remodeling male nonhuman rat Animals Disease Models, Animal Male Myocardial Infarction Rats, Wistar Time Factors Ventricular Dysfunction, Left Ventricular Remodeling |
description |
Background: The prediction of the ventricular remodeling process after acute myocardial infarction (AMI) may have important clinical implications. Objetive: To analyze echocardiographic variables predictors of remodeling in the infarction model in rats. Methods: The animals underwent echocardiography in two moments, five days and three months after infarction (AMI group) or sham surgery (control group). Linear regression was used to identify the echocardiographic variables on the fifth day after the infarction, which were predictive of remodeling after three months of coronary occlusion. We considered as a criterion of remodeling in this study, the values of left ventricular diastolic diameter (LVDD) after three months of infarction. Results: The infarction induced increase in the left chambers, associated with changes in systolic and diastolic functions. The variables body weight, left ventricular wall stress index (LVWSI), systolic area (SA), diastolic area (DA), LVDD, left ventricular systolic diameter (LVSD), fractional area change (FAC), ejection fraction (EF), fractional shortening (%Short), posterior wall shortening velocity (PWSV) and infarct size assessed five days after infarction were predictors of LVDD after three months. At the multivariate regression analysis, we included the size of infarction, the LVWSI and PWSV. The LVWSI (coefficient: 4.402, standard error: 2.221, p = 0.05), but not the size of infarction and PWSV, was a predictor of remodeling after three months of infarction. Conclusion: LVPSI was an independent predictor of remodeling three months after the myocardial infarction and could be included in the clinical stratification after the coronary occlusion. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 2014-05-27T11:26:15Z 2014-05-27T11:26:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0066-782X2011005000117 Arquivos Brasileiros de Cardiologia, v. 97, n. 6, p. 502-506, 2011. 0066-782X 1678-4170 http://hdl.handle.net/11449/72879 10.1590/S0066-782X2011005000117 S0066-782X2011005000117 2-s2.0-84856358242 2-s2.0-84856358242.pdf 1590971576309420 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
url |
http://dx.doi.org/10.1590/S0066-782X2011005000117 http://hdl.handle.net/11449/72879 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia, v. 97, n. 6, p. 502-506, 2011. 0066-782X 1678-4170 10.1590/S0066-782X2011005000117 S0066-782X2011005000117 2-s2.0-84856358242 2-s2.0-84856358242.pdf 1590971576309420 5016839015394547 1213140801402647 7438704034471673 0000-0002-5843-6232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia 1.318 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
502-506 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128114626134016 |