Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.physbeh.2010.10.014 http://hdl.handle.net/11449/16172 |
Resumo: | The objective of this study was to find out if lipopolysaccharide (LPS) administered intraperitoneally affects sodium and water intake and renal excretion in dehydrated rats. LPS (0.3-5 mg/kg b.w.) inhibited 0.3 M NaCl intake induced by subcutaneous injection of the diuretic furosemide (FUR. 10 mg/kg b.w.) combined with the angiotensin converting enzyme inhibitor, captopril (CAP, 5 mg/kg b.w.). Only the highest doses of LPS (2.5 and 5 mg/kg) inhibited water intake induced by FURO/CAP. LPS (0.6 mg/kg) reduced urinary volume and sodium excretion, but had no effect on mean arterial pressure or heart rate of rats treated with FURO/CAP. LPS (0.3-5.0 mg/kg) abolished intracellular thirst and reduced by 50% the urine sodium concentration of rats that received 2 ml of 2 M NaCl by gavage. LPS (0.3-5.0 mg/kg) also reduced thirst in rats treated with FURO alone (10 mg/rat sc). The results suggest that LPS has a preferential, but not exclusive, inhibitory effect on sodium intake and on intracellular thirst. The inhibition of hydro-mineral intake and the antinatriuresis caused by LPS in dehydrated rats may contribute to the multiple effects of the endotoxin on fluid and electrolyte balance and be part of the strategy to cope with infections. (C) 2010 Elsevier B.V. All rights reserved. |
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Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated ratsLPSSodium appetiteThirstDehydrationKidneySickness behaviorThe objective of this study was to find out if lipopolysaccharide (LPS) administered intraperitoneally affects sodium and water intake and renal excretion in dehydrated rats. LPS (0.3-5 mg/kg b.w.) inhibited 0.3 M NaCl intake induced by subcutaneous injection of the diuretic furosemide (FUR. 10 mg/kg b.w.) combined with the angiotensin converting enzyme inhibitor, captopril (CAP, 5 mg/kg b.w.). Only the highest doses of LPS (2.5 and 5 mg/kg) inhibited water intake induced by FURO/CAP. LPS (0.6 mg/kg) reduced urinary volume and sodium excretion, but had no effect on mean arterial pressure or heart rate of rats treated with FURO/CAP. LPS (0.3-5.0 mg/kg) abolished intracellular thirst and reduced by 50% the urine sodium concentration of rats that received 2 ml of 2 M NaCl by gavage. LPS (0.3-5.0 mg/kg) also reduced thirst in rats treated with FURO alone (10 mg/rat sc). The results suggest that LPS has a preferential, but not exclusive, inhibitory effect on sodium intake and on intracellular thirst. The inhibition of hydro-mineral intake and the antinatriuresis caused by LPS in dehydrated rats may contribute to the multiple effects of the endotoxin on fluid and electrolyte balance and be part of the strategy to cope with infections. (C) 2010 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)São Paulo State Univ UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 São Paulo, BrazilSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801903 São Paulo, BrazilSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Prod & Toxicol, BR-14801903 São Paulo, BrazilSão Paulo State Univ UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 São Paulo, BrazilSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801903 São Paulo, BrazilSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Prod & Toxicol, BR-14801903 São Paulo, BrazilPergamon-Elsevier B.V. LtdUniversidade Estadual Paulista (Unesp)Almeida, Roberto L. de [UNESP]Constancio, Juliana [UNESP]Vendramini, Regina Célia [UNESP]Fracasso, Jose F. [UNESP]Menani, José Vanderlei [UNESP]De Luca, Laurival A. [UNESP]2014-05-20T13:45:51Z2014-05-20T13:45:51Z2011-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article164-169application/pdfhttp://dx.doi.org/10.1016/j.physbeh.2010.10.014Physiology & Behavior. Oxford: Pergamon-Elsevier B.V. Ltd, v. 102, n. 2, p. 164-169, 2011.0031-9384http://hdl.handle.net/11449/1617210.1016/j.physbeh.2010.10.014WOS:000286711200008WOS000286711200008.pdf7641979287850489Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiology & Behavior2.5171,088info:eu-repo/semantics/openAccess2024-06-24T14:51:40Zoai:repositorio.unesp.br:11449/16172Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:03:35.157252Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats |
title |
Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats |
spellingShingle |
Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats Almeida, Roberto L. de [UNESP] LPS Sodium appetite Thirst Dehydration Kidney Sickness behavior |
title_short |
Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats |
title_full |
Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats |
title_fullStr |
Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats |
title_full_unstemmed |
Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats |
title_sort |
Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats |
author |
Almeida, Roberto L. de [UNESP] |
author_facet |
Almeida, Roberto L. de [UNESP] Constancio, Juliana [UNESP] Vendramini, Regina Célia [UNESP] Fracasso, Jose F. [UNESP] Menani, José Vanderlei [UNESP] De Luca, Laurival A. [UNESP] |
author_role |
author |
author2 |
Constancio, Juliana [UNESP] Vendramini, Regina Célia [UNESP] Fracasso, Jose F. [UNESP] Menani, José Vanderlei [UNESP] De Luca, Laurival A. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Almeida, Roberto L. de [UNESP] Constancio, Juliana [UNESP] Vendramini, Regina Célia [UNESP] Fracasso, Jose F. [UNESP] Menani, José Vanderlei [UNESP] De Luca, Laurival A. [UNESP] |
dc.subject.por.fl_str_mv |
LPS Sodium appetite Thirst Dehydration Kidney Sickness behavior |
topic |
LPS Sodium appetite Thirst Dehydration Kidney Sickness behavior |
description |
The objective of this study was to find out if lipopolysaccharide (LPS) administered intraperitoneally affects sodium and water intake and renal excretion in dehydrated rats. LPS (0.3-5 mg/kg b.w.) inhibited 0.3 M NaCl intake induced by subcutaneous injection of the diuretic furosemide (FUR. 10 mg/kg b.w.) combined with the angiotensin converting enzyme inhibitor, captopril (CAP, 5 mg/kg b.w.). Only the highest doses of LPS (2.5 and 5 mg/kg) inhibited water intake induced by FURO/CAP. LPS (0.6 mg/kg) reduced urinary volume and sodium excretion, but had no effect on mean arterial pressure or heart rate of rats treated with FURO/CAP. LPS (0.3-5.0 mg/kg) abolished intracellular thirst and reduced by 50% the urine sodium concentration of rats that received 2 ml of 2 M NaCl by gavage. LPS (0.3-5.0 mg/kg) also reduced thirst in rats treated with FURO alone (10 mg/rat sc). The results suggest that LPS has a preferential, but not exclusive, inhibitory effect on sodium intake and on intracellular thirst. The inhibition of hydro-mineral intake and the antinatriuresis caused by LPS in dehydrated rats may contribute to the multiple effects of the endotoxin on fluid and electrolyte balance and be part of the strategy to cope with infections. (C) 2010 Elsevier B.V. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02-01 2014-05-20T13:45:51Z 2014-05-20T13:45:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.physbeh.2010.10.014 Physiology & Behavior. Oxford: Pergamon-Elsevier B.V. Ltd, v. 102, n. 2, p. 164-169, 2011. 0031-9384 http://hdl.handle.net/11449/16172 10.1016/j.physbeh.2010.10.014 WOS:000286711200008 WOS000286711200008.pdf 7641979287850489 |
url |
http://dx.doi.org/10.1016/j.physbeh.2010.10.014 http://hdl.handle.net/11449/16172 |
identifier_str_mv |
Physiology & Behavior. Oxford: Pergamon-Elsevier B.V. Ltd, v. 102, n. 2, p. 164-169, 2011. 0031-9384 10.1016/j.physbeh.2010.10.014 WOS:000286711200008 WOS000286711200008.pdf 7641979287850489 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physiology & Behavior 2.517 1,088 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
164-169 application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier B.V. Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier B.V. Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128602456195072 |