Avaliação temporal da pressão arterial durante treinamento físico aeróbio, associado ou não ao tratamento com Perindopril em ratos espontaneamente hipertensos

• Autor(a) principal: Cunha, Gustavo Henrique Alves de Freitas [UNESP]
• Data de Publicação: 2018
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/203136; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2019-03-19/000913024.pdf
• topic: Hipertensão; Enzima conversora da angiotensina; Exercícios físicos; Hypertension

There are several forms of treatment for Arterial Hypertension, which os a chronic disease characterized by sustained high systolic and diastolic blood pressure (BP), which is one of the main causes for the development of cardiovascular diseases. Among tretaments, there are pharmacological and non-pharmacological, such as physical training (T). Isolated, both are capable to decrease BP, however, little is known about the effects of the combination of TF and the use of drugs on the behavior of the BP. It is important to determine what treatment is more effective, which one responds first and if the combination of the two strategies would be more effective in controlling BP. Objectives: The objective of this study was to perform a time-course assessment of blood pressure during aerobic physical training, associated or not with Perindopril treatment in spontaneously hypertensive rats. METHODS: We selected 19 spontaneously hypertensive rats (SHR), divided into 4 groups: sedentary control (SC), sedentary perindopril (SP), trained control (TC) and trained perindopril (TP), who underwent a physical training protocol (60% of the maximum physical capacity, 5 days a week, for 60 days). The rats were treated with perindopril or water (3mg / kg, per day, via gavage). In addition, 10 Wistar rats were used as normotensive control group. All rats were submitted to maximal stress test and caudal blood pressure measurement, which were measured weekly. Statistical analysis were 1, 2 or 3-way ANOVA (p <0.05)... (Complete abstract electronic access below)