Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection

Detalhes bibliográficos
Autor(a) principal: Salomão Junior, João Batista
Data de Publicação: 2011
Outros Autores: Gardinassi, Luiz G. A. [UNESP], Simas, Paulo V. M. [UNESP], Bittar, Cintia O. [UNESP], Souza, Fátima Pereira de [UNESP], Rahal, Paula [UNESP], Zanetta, Dirce M. T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2223/JPED.2085
http://hdl.handle.net/11449/21602
Resumo: Objective: To evaluate the prevalence and seasonality of human respiratory syncytial virus (HRSV) in children aged 0 to 6 years, hospitalized with acute lower respiratory infection (ALRI) in Sao Jose do Rio Preto, SP, Brazil, and the association between age, diagnosis, and HRSV.Methods: Between May 2004 and September 2005, we studied 290 consecutive episodes of community-acquired ALRI in children aged 0 to 6 years admitted to the Hospital de Base of Sao Jose do Rio Preto. In order to detect HRSV, nasopharyngeal secretion samples were collected and RT-PCR molecular analysis was performed.Results: The HRSV prevalence was 29.3% for the cases of hospitalized patients with ALRI. ALRI was common in infants (median age = 13.5 months). HRSV was more frequent in cases of bronchiolitis (64%) and during the first year of life (35%). Episodes of HRSV infection occurred between fall and spring, showing higher frequency in 2004 than in 2005. Clinical and radiological criteria were not sufficient to establish the diagnosis of infection with HRSV. Antibiotic therapy was used in 78.8% of episodes of HRSV.Conclusions: There was a high prevalence of HRSV in children aged 0 to 6 years who were hospitalized for ALRI, predominantly in younger patients or those with bronchiolitis. The circulation of the virus varied in the two years studied. Our results suggest the need for laboratory diagnosis of HRSV in the clinical practice.
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spelling Human respiratory syncytial virus in children hospitalized for acute lower respiratory infectionRespiratory infectionshuman respiratory syncytial virushospitalized childrenbronchiolitisObjective: To evaluate the prevalence and seasonality of human respiratory syncytial virus (HRSV) in children aged 0 to 6 years, hospitalized with acute lower respiratory infection (ALRI) in Sao Jose do Rio Preto, SP, Brazil, and the association between age, diagnosis, and HRSV.Methods: Between May 2004 and September 2005, we studied 290 consecutive episodes of community-acquired ALRI in children aged 0 to 6 years admitted to the Hospital de Base of Sao Jose do Rio Preto. In order to detect HRSV, nasopharyngeal secretion samples were collected and RT-PCR molecular analysis was performed.Results: The HRSV prevalence was 29.3% for the cases of hospitalized patients with ALRI. ALRI was common in infants (median age = 13.5 months). HRSV was more frequent in cases of bronchiolitis (64%) and during the first year of life (35%). Episodes of HRSV infection occurred between fall and spring, showing higher frequency in 2004 than in 2005. Clinical and radiological criteria were not sufficient to establish the diagnosis of infection with HRSV. Antibiotic therapy was used in 78.8% of episodes of HRSV.Conclusions: There was a high prevalence of HRSV in children aged 0 to 6 years who were hospitalized for ALRI, predominantly in younger patients or those with bronchiolitis. The circulation of the virus varied in the two years studied. Our results suggest the need for laboratory diagnosis of HRSV in the clinical practice.OBJETIVO: Avaliar a prevalência e a sazonalidade do vírus respiratório sincicial humano (VRSH) em crianças de 0 a 6 anos hospitalizadas por infecção aguda das vias aéreas inferiores (IVAI) em São José do Rio Preto (SP) e a associação entre faixa etária, diagnóstico e VRSH. MÉTODOS: Entre maio de 2004 e setembro de 2005, foram estudados 290 episódios consecutivos de IVAI adquiridos na comunidade em crianças de 0 a 6 anos internadas no Hospital de Base de São José do Rio Preto. Para identificação do VRSH, foram coletadas amostras de secreção de nasofaringe e realizou-se análise molecular por meio da técnica de RT-PCR. RESULTADOS: A prevalência de VRSH foi de 29,3% nos episódios de IVAI hospitalizados. A IVAI foi frequente em lactentes (mediana de idade = 13,5 meses). O VRSH foi mais frequente nos casos de bronquiolite (64%) e no primeiro ano de vida (35%). Os episódios de infecção por VRSH ocorreram entre o outono e a primavera, com frequência maior em 2004 do que em 2005. Os critérios clínicos e radiológicos não foram suficientes para o diagnóstico de infecção pelo VRSH. Em 78,8% dos episódios de VRSH, houve tratamento com antibiótico. CONCLUSÕES: A prevalência do VRSH em crianças de 0 a 6 anos hospitalizadas por IVAI foi elevada, com predomínio nas mais jovens ou com bronquiolite. A circulação do vírus variou nos dois anos estudados. Os resultados sugerem necessidade de diagnóstico laboratorial do VRSR na prática clínica.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fac Med Sao Jose Rio Preto FAMERP, Sao Jose do Rio Preto, SP, BrazilUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas IBILCE, Sao Jose do Rio Preto, SP, BrazilUniv Estadual Paulista, Microbiol IBILCE, Sao Jose do Rio Preto, SP, BrazilUniv Estadual Paulista, IBILCE, Sao Jose do Rio Preto, SP, BrazilFAMERP, Sao Jose do Rio Preto, SP, BrazilUniv São Paulo, Fac Saúde Publ, São Paulo, BrazilUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas IBILCE, Sao Jose do Rio Preto, SP, BrazilUniv Estadual Paulista, Microbiol IBILCE, Sao Jose do Rio Preto, SP, BrazilUniv Estadual Paulista, IBILCE, Sao Jose do Rio Preto, SP, BrazilFAPESP: 04/06883-2Sociedade Brasileira de PediatriaUniversidade Estadual Paulista (Unesp)Faculdade de Medicina de São José do Rio Preto (FAMERP)Universidade de São Paulo (USP)Salomão Junior, João BatistaGardinassi, Luiz G. A. [UNESP]Simas, Paulo V. M. [UNESP]Bittar, Cintia O. [UNESP]Souza, Fátima Pereira de [UNESP]Rahal, Paula [UNESP]Zanetta, Dirce M. T.2014-05-20T14:01:07Z2014-05-20T14:01:07Z2011-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article219-224application/pdfapplication/pdfhttp://dx.doi.org/10.2223/JPED.2085Jornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 87, n. 3, p. 219-224, 2011.0021-7557http://hdl.handle.net/11449/2160210.2223/JPED.2085S0021-75572011000300007WOS:000292405300007S0021-75572011000300007-en.pdfS0021-75572011000300007-pt.pdf799108236267121233135113347839860000-0001-5693-61480000-0002-4731-4977Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJornal de Pediatria1.6900,704info:eu-repo/semantics/openAccess2023-11-05T06:07:43Zoai:repositorio.unesp.br:11449/21602Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:57:24.491937Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection
title Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection
spellingShingle Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection
Salomão Junior, João Batista
Respiratory infections
human respiratory syncytial virus
hospitalized children
bronchiolitis
title_short Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection
title_full Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection
title_fullStr Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection
title_full_unstemmed Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection
title_sort Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection
author Salomão Junior, João Batista
author_facet Salomão Junior, João Batista
Gardinassi, Luiz G. A. [UNESP]
Simas, Paulo V. M. [UNESP]
Bittar, Cintia O. [UNESP]
Souza, Fátima Pereira de [UNESP]
Rahal, Paula [UNESP]
Zanetta, Dirce M. T.
author_role author
author2 Gardinassi, Luiz G. A. [UNESP]
Simas, Paulo V. M. [UNESP]
Bittar, Cintia O. [UNESP]
Souza, Fátima Pereira de [UNESP]
Rahal, Paula [UNESP]
Zanetta, Dirce M. T.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Faculdade de Medicina de São José do Rio Preto (FAMERP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Salomão Junior, João Batista
Gardinassi, Luiz G. A. [UNESP]
Simas, Paulo V. M. [UNESP]
Bittar, Cintia O. [UNESP]
Souza, Fátima Pereira de [UNESP]
Rahal, Paula [UNESP]
Zanetta, Dirce M. T.
dc.subject.por.fl_str_mv Respiratory infections
human respiratory syncytial virus
hospitalized children
bronchiolitis
topic Respiratory infections
human respiratory syncytial virus
hospitalized children
bronchiolitis
description Objective: To evaluate the prevalence and seasonality of human respiratory syncytial virus (HRSV) in children aged 0 to 6 years, hospitalized with acute lower respiratory infection (ALRI) in Sao Jose do Rio Preto, SP, Brazil, and the association between age, diagnosis, and HRSV.Methods: Between May 2004 and September 2005, we studied 290 consecutive episodes of community-acquired ALRI in children aged 0 to 6 years admitted to the Hospital de Base of Sao Jose do Rio Preto. In order to detect HRSV, nasopharyngeal secretion samples were collected and RT-PCR molecular analysis was performed.Results: The HRSV prevalence was 29.3% for the cases of hospitalized patients with ALRI. ALRI was common in infants (median age = 13.5 months). HRSV was more frequent in cases of bronchiolitis (64%) and during the first year of life (35%). Episodes of HRSV infection occurred between fall and spring, showing higher frequency in 2004 than in 2005. Clinical and radiological criteria were not sufficient to establish the diagnosis of infection with HRSV. Antibiotic therapy was used in 78.8% of episodes of HRSV.Conclusions: There was a high prevalence of HRSV in children aged 0 to 6 years who were hospitalized for ALRI, predominantly in younger patients or those with bronchiolitis. The circulation of the virus varied in the two years studied. Our results suggest the need for laboratory diagnosis of HRSV in the clinical practice.
publishDate 2011
dc.date.none.fl_str_mv 2011-05-01
2014-05-20T14:01:07Z
2014-05-20T14:01:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2223/JPED.2085
Jornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 87, n. 3, p. 219-224, 2011.
0021-7557
http://hdl.handle.net/11449/21602
10.2223/JPED.2085
S0021-75572011000300007
WOS:000292405300007
S0021-75572011000300007-en.pdf
S0021-75572011000300007-pt.pdf
7991082362671212
3313511334783986
0000-0001-5693-6148
0000-0002-4731-4977
url http://dx.doi.org/10.2223/JPED.2085
http://hdl.handle.net/11449/21602
identifier_str_mv Jornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 87, n. 3, p. 219-224, 2011.
0021-7557
10.2223/JPED.2085
S0021-75572011000300007
WOS:000292405300007
S0021-75572011000300007-en.pdf
S0021-75572011000300007-pt.pdf
7991082362671212
3313511334783986
0000-0001-5693-6148
0000-0002-4731-4977
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language eng
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dc.format.none.fl_str_mv 219-224
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application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
publisher.none.fl_str_mv Sociedade Brasileira de Pediatria
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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