Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin aging
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2015/818656 http://hdl.handle.net/11449/177715 |
Resumo: | The availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin. Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the field of dermatological products. Recent studies have shown the influence of the rheological features of a vehicle on the release of drugs and active compounds from the formulation. In this context, the aim of this study was to evaluate the influence of the rheological features of two different emulsion formulations on the release of alpha-lipoic acid. Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging. The rheological and mechanical behavior and the in vitro release profile were assayed. The results showed that rheological features, such as viscosity, thixotropy, and compliance, strongly influenced the release of ALA from the emulsion and that the presence of a hydrophilic polymer in one of the emulsions was an important factor affecting the rheology and, therefore, the release of ALA. |
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Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin agingThe availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin. Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the field of dermatological products. Recent studies have shown the influence of the rheological features of a vehicle on the release of drugs and active compounds from the formulation. In this context, the aim of this study was to evaluate the influence of the rheological features of two different emulsion formulations on the release of alpha-lipoic acid. Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging. The rheological and mechanical behavior and the in vitro release profile were assayed. The results showed that rheological features, such as viscosity, thixotropy, and compliance, strongly influenced the release of ALA from the emulsion and that the presence of a hydrophilic polymer in one of the emulsions was an important factor affecting the rheology and, therefore, the release of ALA.Faculdade de Ciências Farmacêuticas UNESP Univ Estadual Paulista LaCos, Rodovia Araraquara Jau, Km 1Centro Universitário de Araraquara (UNIARA), Rua Carlos Gomes 1338Research Institute for Medicines and Pharmaceutical Sciences (IMed.UL) Faculty of Pharmacy University of Lisbon, Avenida Prof. Gama PintoFaculdade de Ciências Farmacêuticas UNESP Univ Estadual Paulista LaCos, Rodovia Araraquara Jau, Km 1Universidade Estadual Paulista (Unesp)Centro Universitário de Araraquara (UNIARA)University of LisbonIsaac, Vera Lucia Borges [UNESP]Chiari-Andréo, Bruna Galdorfini [UNESP]Marto, Joana MarquesMoraes, Jemima Daniela Dias [UNESP]Leone, Beatriz Alves [UNESP]Corrêa, Marcos Antonio [UNESP]Ribeiro, Helena Margarida2018-12-11T17:26:45Z2018-12-11T17:26:45Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2015/818656BioMed Research International, v. 2015.2314-61412314-6133http://hdl.handle.net/11449/17771510.1155/2015/8186562-s2.0-849541371212-s2.0-84954137121.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioMed Research International0,9350,935info:eu-repo/semantics/openAccess2023-12-29T06:17:40Zoai:repositorio.unesp.br:11449/177715Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-29T06:17:40Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin aging |
title |
Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin aging |
spellingShingle |
Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin aging Isaac, Vera Lucia Borges [UNESP] |
title_short |
Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin aging |
title_full |
Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin aging |
title_fullStr |
Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin aging |
title_full_unstemmed |
Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin aging |
title_sort |
Rheology as a tool to predict the release of alpha-lipoic acid from emulsions used for the prevention of skin aging |
author |
Isaac, Vera Lucia Borges [UNESP] |
author_facet |
Isaac, Vera Lucia Borges [UNESP] Chiari-Andréo, Bruna Galdorfini [UNESP] Marto, Joana Marques Moraes, Jemima Daniela Dias [UNESP] Leone, Beatriz Alves [UNESP] Corrêa, Marcos Antonio [UNESP] Ribeiro, Helena Margarida |
author_role |
author |
author2 |
Chiari-Andréo, Bruna Galdorfini [UNESP] Marto, Joana Marques Moraes, Jemima Daniela Dias [UNESP] Leone, Beatriz Alves [UNESP] Corrêa, Marcos Antonio [UNESP] Ribeiro, Helena Margarida |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Centro Universitário de Araraquara (UNIARA) University of Lisbon |
dc.contributor.author.fl_str_mv |
Isaac, Vera Lucia Borges [UNESP] Chiari-Andréo, Bruna Galdorfini [UNESP] Marto, Joana Marques Moraes, Jemima Daniela Dias [UNESP] Leone, Beatriz Alves [UNESP] Corrêa, Marcos Antonio [UNESP] Ribeiro, Helena Margarida |
description |
The availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin. Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the field of dermatological products. Recent studies have shown the influence of the rheological features of a vehicle on the release of drugs and active compounds from the formulation. In this context, the aim of this study was to evaluate the influence of the rheological features of two different emulsion formulations on the release of alpha-lipoic acid. Alpha-lipoic acid (ALA) was chosen for this study because of its antioxidant characteristics, which could be useful for the prevention of skin diseases and aging. The rheological and mechanical behavior and the in vitro release profile were assayed. The results showed that rheological features, such as viscosity, thixotropy, and compliance, strongly influenced the release of ALA from the emulsion and that the presence of a hydrophilic polymer in one of the emulsions was an important factor affecting the rheology and, therefore, the release of ALA. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 2018-12-11T17:26:45Z 2018-12-11T17:26:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2015/818656 BioMed Research International, v. 2015. 2314-6141 2314-6133 http://hdl.handle.net/11449/177715 10.1155/2015/818656 2-s2.0-84954137121 2-s2.0-84954137121.pdf |
url |
http://dx.doi.org/10.1155/2015/818656 http://hdl.handle.net/11449/177715 |
identifier_str_mv |
BioMed Research International, v. 2015. 2314-6141 2314-6133 10.1155/2015/818656 2-s2.0-84954137121 2-s2.0-84954137121.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BioMed Research International 0,935 0,935 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965444624351232 |