Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1007/s10973-019-08958-3 http://hdl.handle.net/11449/198126 |
Resumo: | Novel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams. |
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Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acidCiprofloxacinCocrystalMechanochemical synthesisThermal analysisNovel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Institute of Chemistry São Paulo State University (UNESP)School of Sciences São Paulo State University (UNESP)Institute of Chemistry São Paulo State University (UNESP)School of Sciences São Paulo State University (UNESP)CAPES: 001FAPESP: 2013/09022-7FAPESP: 2017/14936-9FAPESP: 2018/12463-9FAPESP: 2018/24378-6Universidade Estadual Paulista (Unesp)de Almeida, Amanda Cosmo [UNESP]Ferreira, Patrícia Osório [UNESP]Torquetti, Carolina [UNESP]Ekawa, Bruno [UNESP]Carvalho, Ana Carina Sobral [UNESP]dos Santos, Everton Carvalho [UNESP]Caires, Flávio Junior [UNESP]2020-12-12T00:59:53Z2020-12-12T00:59:53Z2020-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2293-2303http://dx.doi.org/10.1007/s10973-019-08958-3Journal of Thermal Analysis and Calorimetry, v. 140, n. 5, p. 2293-2303, 2020.1588-29261388-6150http://hdl.handle.net/11449/19812610.1007/s10973-019-08958-32-s2.0-85074838952Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Thermal Analysis and Calorimetryinfo:eu-repo/semantics/openAccess2021-10-23T08:59:34Zoai:repositorio.unesp.br:11449/198126Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T20:34:21.222490Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid |
| title |
Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid |
| spellingShingle |
Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid de Almeida, Amanda Cosmo [UNESP] Ciprofloxacin Cocrystal Mechanochemical synthesis Thermal analysis |
| title_short |
Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid |
| title_full |
Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid |
| title_fullStr |
Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid |
| title_full_unstemmed |
Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid |
| title_sort |
Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid |
| author |
de Almeida, Amanda Cosmo [UNESP] |
| author_facet |
de Almeida, Amanda Cosmo [UNESP] Ferreira, Patrícia Osório [UNESP] Torquetti, Carolina [UNESP] Ekawa, Bruno [UNESP] Carvalho, Ana Carina Sobral [UNESP] dos Santos, Everton Carvalho [UNESP] Caires, Flávio Junior [UNESP] |
| author_role |
author |
| author2 |
Ferreira, Patrícia Osório [UNESP] Torquetti, Carolina [UNESP] Ekawa, Bruno [UNESP] Carvalho, Ana Carina Sobral [UNESP] dos Santos, Everton Carvalho [UNESP] Caires, Flávio Junior [UNESP] |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
| dc.contributor.author.fl_str_mv |
de Almeida, Amanda Cosmo [UNESP] Ferreira, Patrícia Osório [UNESP] Torquetti, Carolina [UNESP] Ekawa, Bruno [UNESP] Carvalho, Ana Carina Sobral [UNESP] dos Santos, Everton Carvalho [UNESP] Caires, Flávio Junior [UNESP] |
| dc.subject.por.fl_str_mv |
Ciprofloxacin Cocrystal Mechanochemical synthesis Thermal analysis |
| topic |
Ciprofloxacin Cocrystal Mechanochemical synthesis Thermal analysis |
| description |
Novel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12-12T00:59:53Z 2020-12-12T00:59:53Z 2020-06-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10973-019-08958-3 Journal of Thermal Analysis and Calorimetry, v. 140, n. 5, p. 2293-2303, 2020. 1588-2926 1388-6150 http://hdl.handle.net/11449/198126 10.1007/s10973-019-08958-3 2-s2.0-85074838952 |
| url |
http://dx.doi.org/10.1007/s10973-019-08958-3 http://hdl.handle.net/11449/198126 |
| identifier_str_mv |
Journal of Thermal Analysis and Calorimetry, v. 140, n. 5, p. 2293-2303, 2020. 1588-2926 1388-6150 10.1007/s10973-019-08958-3 2-s2.0-85074838952 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal of Thermal Analysis and Calorimetry |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
2293-2303 |
| dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1803045682050760704 |