Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/12633 http://hdl.handle.net/11449/71401 |
Resumo: | The aims of this investigation was to evaluate the effect of hepatoprotective treatments with a compound prepared by the association of N-Acetyl DL-Methionine (5%) + Choline chloride (2%) + Caffeine (1%) + Thiamine hydrochloride (1%) + Nicotinamida (0,5%)+ Pyridoxine hydrochloride (0.04%), administered through intramuscular (IM) route, at doses of 0.2, 0.6 and 1.0 mL/kg of BW, through the study of leukocytes responses in rats submitted to acute intoxication with CCl4. 147 females were randomized into 21 groups, performing five different treatments, which were evaluated seven animals in four periods: two, four, six and eight days after CCl4-induced intoxication. In this study, it was observed absolute eosinophilia and monocytosis in animals untreated and treated with the lowest dose of 0.2 mL. These responses were significantly better in animals treated with 0.6 and 1.0 mL/ kg BW. The untreated animals showed thrombocytopenia, when compared to treated animals. Absolute neutropenia and lymphocytosis was observed in all rats intoxicated with CCl4, there is no difference among treatments. The analysis of white blood cells demonstrated that the hepatoprotective treatments favored the leukocyte response, by act beneficially on the population of these cells, supporting the hypothesis that these events may reduce the deleterious effects in liver tissue after intoxication by CCl4. |
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Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4Hepatoprotective treatment improves leukocyte responses of Wistar rats intoxicated by CCl4Carbon tetrachlorideHepatoprotectiveLeukocytesRatsAnimaliaRattusRattus norvegicusThe aims of this investigation was to evaluate the effect of hepatoprotective treatments with a compound prepared by the association of N-Acetyl DL-Methionine (5%) + Choline chloride (2%) + Caffeine (1%) + Thiamine hydrochloride (1%) + Nicotinamida (0,5%)+ Pyridoxine hydrochloride (0.04%), administered through intramuscular (IM) route, at doses of 0.2, 0.6 and 1.0 mL/kg of BW, through the study of leukocytes responses in rats submitted to acute intoxication with CCl4. 147 females were randomized into 21 groups, performing five different treatments, which were evaluated seven animals in four periods: two, four, six and eight days after CCl4-induced intoxication. In this study, it was observed absolute eosinophilia and monocytosis in animals untreated and treated with the lowest dose of 0.2 mL. These responses were significantly better in animals treated with 0.6 and 1.0 mL/ kg BW. The untreated animals showed thrombocytopenia, when compared to treated animals. Absolute neutropenia and lymphocytosis was observed in all rats intoxicated with CCl4, there is no difference among treatments. The analysis of white blood cells demonstrated that the hepatoprotective treatments favored the leukocyte response, by act beneficially on the population of these cells, supporting the hypothesis that these events may reduce the deleterious effects in liver tissue after intoxication by CCl4.Unicastelo, Descalvado/SPCPPAR- Depto. Patologia Veterinária FCAV/Unesp Campus de JaboticabalDepto. de Pesquisas Veterinárias Empresa Ouro Fino Saúde Animal LtdaCPPAR- Depto. Patologia Veterinária FCAV/Unesp Campus de JaboticabalUnicasteloUniversidade Estadual Paulista (Unesp)Empresa Ouro Fino Saúde Animal LtdaBelo, M. A A [UNESP]Souza, L. M. [UNESP]Soares, V. E. [UNESP]Sobreira, M. F RCasol, D. M SToma, S. B.2014-05-27T11:24:32Z2014-05-27T11:24:32Z2009-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article74-82application/pdfhttp://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/12633Archives of Veterinary Science, v. 14, n. 2, p. 74-82, 2009.1517-784Xhttp://hdl.handle.net/11449/714012-s2.0-779551657022-s2.0-77955165702.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArchives of Veterinary Scienceinfo:eu-repo/semantics/openAccess2024-04-12T13:07:00Zoai:repositorio.unesp.br:11449/71401Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-12T13:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4 Hepatoprotective treatment improves leukocyte responses of Wistar rats intoxicated by CCl4 |
title |
Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4 |
spellingShingle |
Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4 Belo, M. A A [UNESP] Carbon tetrachloride Hepatoprotective Leukocytes Rats Animalia Rattus Rattus norvegicus |
title_short |
Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4 |
title_full |
Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4 |
title_fullStr |
Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4 |
title_full_unstemmed |
Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4 |
title_sort |
Tratamento hepatoprotetor favorece a resposta leucocitária de ratos wistar intoxicados por CCL4 |
author |
Belo, M. A A [UNESP] |
author_facet |
Belo, M. A A [UNESP] Souza, L. M. [UNESP] Soares, V. E. [UNESP] Sobreira, M. F R Casol, D. M S Toma, S. B. |
author_role |
author |
author2 |
Souza, L. M. [UNESP] Soares, V. E. [UNESP] Sobreira, M. F R Casol, D. M S Toma, S. B. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Unicastelo Universidade Estadual Paulista (Unesp) Empresa Ouro Fino Saúde Animal Ltda |
dc.contributor.author.fl_str_mv |
Belo, M. A A [UNESP] Souza, L. M. [UNESP] Soares, V. E. [UNESP] Sobreira, M. F R Casol, D. M S Toma, S. B. |
dc.subject.por.fl_str_mv |
Carbon tetrachloride Hepatoprotective Leukocytes Rats Animalia Rattus Rattus norvegicus |
topic |
Carbon tetrachloride Hepatoprotective Leukocytes Rats Animalia Rattus Rattus norvegicus |
description |
The aims of this investigation was to evaluate the effect of hepatoprotective treatments with a compound prepared by the association of N-Acetyl DL-Methionine (5%) + Choline chloride (2%) + Caffeine (1%) + Thiamine hydrochloride (1%) + Nicotinamida (0,5%)+ Pyridoxine hydrochloride (0.04%), administered through intramuscular (IM) route, at doses of 0.2, 0.6 and 1.0 mL/kg of BW, through the study of leukocytes responses in rats submitted to acute intoxication with CCl4. 147 females were randomized into 21 groups, performing five different treatments, which were evaluated seven animals in four periods: two, four, six and eight days after CCl4-induced intoxication. In this study, it was observed absolute eosinophilia and monocytosis in animals untreated and treated with the lowest dose of 0.2 mL. These responses were significantly better in animals treated with 0.6 and 1.0 mL/ kg BW. The untreated animals showed thrombocytopenia, when compared to treated animals. Absolute neutropenia and lymphocytosis was observed in all rats intoxicated with CCl4, there is no difference among treatments. The analysis of white blood cells demonstrated that the hepatoprotective treatments favored the leukocyte response, by act beneficially on the population of these cells, supporting the hypothesis that these events may reduce the deleterious effects in liver tissue after intoxication by CCl4. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 2014-05-27T11:24:32Z 2014-05-27T11:24:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/12633 Archives of Veterinary Science, v. 14, n. 2, p. 74-82, 2009. 1517-784X http://hdl.handle.net/11449/71401 2-s2.0-77955165702 2-s2.0-77955165702.pdf |
url |
http://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/12633 http://hdl.handle.net/11449/71401 |
identifier_str_mv |
Archives of Veterinary Science, v. 14, n. 2, p. 74-82, 2009. 1517-784X 2-s2.0-77955165702 2-s2.0-77955165702.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Archives of Veterinary Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
74-82 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965072671375360 |