Avaliação da densidade radiográfica no reparo alveolar de ratas ovariectomizadas tratadas com o imunomodulador P-MAPA

• Autor(a) principal: Silva, Tales Candido Garcia da [UNESP]
• Data de Publicação: 2010
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149424; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-26/000855184.pdf
• topic: Ovariectomia; Fatores imunológicos; Radiografia; Ovariectomy

Osteoporosis is a disease characterized by low bone mass and deterioration of bone tissue mineralization microaquitetural generated by estrogen deficiency displayed by sufferers. Recently osteoporosis has emerged as a major public health problem and comes to the relationship between estrogen deficiency and bone metabolism. The health professionals have great interest in the subject, leading to the study drugs that may assist the process of bone remodeling and repair. Aiming to evaluate the effectiveness of a new immunomodulator, P-MAPA, the process of alveolar repair in ovariectomized rats through the radiographic method, we used 60 rats with three months of age. Thirty were ovariectomized (OVZ) and the other 30 were false-operated (SHAM), and half of each group received the medication mentioned. Was extracted from the upper right central incisor 15 days after ovariectomy or sham surgery. On day seven, 21 and 45 days after extraction, was the sacrifice of animals. After statistical analysis of results obtained by the Tukey test, there was only statistically significant difference when comparing the repair times in each group, however, the difference was not established when groups in certain experimental times. Based on these, we can conclude that the method used for radiographic analysis of alveolar repair in not possible to verify significant differences between groups OVZ or SHAM, and treated or not in different repair times, the treated group with P-MAPA appeared suffer any influence of the drug tested, generating more modulated optical densities when examined times of experiment. We also showed the need for additional experiments with larger followup time for the verification of differences using the methodology of radiological images and the association of the experimental findings of this study with other sensitive methods such as microscopic...