Extracellular vesicles: structure, function, and potential clinical uses in renal diseases
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1414-431X20132964 http://hdl.handle.net/11449/211264 |
Resumo: | Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40-100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. The therapeutic potential of extracellular vesicles is very broad, with applications including a route of drug delivery and as biomarkers for diagnosis. Extracellular vesicles extracted from stem cells may be used for treatment of many diseases including kidney diseases. This review highlights mechanisms of synthesis and function, and the potential uses of well-characterized extracellular vesicles, mainly exosomes, with a special focus on renal functions and diseases. |
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Extracellular vesicles: structure, function, and potential clinical uses in renal diseasesExtracellular vesiclesCell biologyKidney diseasesDiagnosisTreatmentInterest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40-100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. The therapeutic potential of extracellular vesicles is very broad, with applications including a route of drug delivery and as biomarkers for diagnosis. Extracellular vesicles extracted from stem cells may be used for treatment of many diseases including kidney diseases. This review highlights mechanisms of synthesis and function, and the potential uses of well-characterized extracellular vesicles, mainly exosomes, with a special focus on renal functions and diseases.Universidade Federal Paulista, Escola Paulista de MedicinaUniversidade Cruzeiro do Sul, Ciências Biológicas e da SaúdeAssociação Brasileira de Divulgação CientíficaUniversidade Federal PaulistaUniversidade Cruzeiro do SulBorges, F.t.Reis, L.a.Schor, N.2021-07-14T10:21:47Z2021-07-14T10:21:47Z2013-10-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article824-830application/pdfhttp://dx.doi.org/10.1590/1414-431X20132964Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 46, n. 10, p. 824-830, 2013.0100-879X1414-431Xhttp://hdl.handle.net/11449/21126410.1590/1414-431X20132964S0100-879X2013001000824S0100-879X2013001000824.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccess2024-01-09T06:26:53Zoai:repositorio.unesp.br:11449/211264Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-09T06:26:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Extracellular vesicles: structure, function, and potential clinical uses in renal diseases |
title |
Extracellular vesicles: structure, function, and potential clinical uses in renal diseases |
spellingShingle |
Extracellular vesicles: structure, function, and potential clinical uses in renal diseases Borges, F.t. Extracellular vesicles Cell biology Kidney diseases Diagnosis Treatment |
title_short |
Extracellular vesicles: structure, function, and potential clinical uses in renal diseases |
title_full |
Extracellular vesicles: structure, function, and potential clinical uses in renal diseases |
title_fullStr |
Extracellular vesicles: structure, function, and potential clinical uses in renal diseases |
title_full_unstemmed |
Extracellular vesicles: structure, function, and potential clinical uses in renal diseases |
title_sort |
Extracellular vesicles: structure, function, and potential clinical uses in renal diseases |
author |
Borges, F.t. |
author_facet |
Borges, F.t. Reis, L.a. Schor, N. |
author_role |
author |
author2 |
Reis, L.a. Schor, N. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Federal Paulista Universidade Cruzeiro do Sul |
dc.contributor.author.fl_str_mv |
Borges, F.t. Reis, L.a. Schor, N. |
dc.subject.por.fl_str_mv |
Extracellular vesicles Cell biology Kidney diseases Diagnosis Treatment |
topic |
Extracellular vesicles Cell biology Kidney diseases Diagnosis Treatment |
description |
Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40-100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. The therapeutic potential of extracellular vesicles is very broad, with applications including a route of drug delivery and as biomarkers for diagnosis. Extracellular vesicles extracted from stem cells may be used for treatment of many diseases including kidney diseases. This review highlights mechanisms of synthesis and function, and the potential uses of well-characterized extracellular vesicles, mainly exosomes, with a special focus on renal functions and diseases. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-10-02 2021-07-14T10:21:47Z 2021-07-14T10:21:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1414-431X20132964 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 46, n. 10, p. 824-830, 2013. 0100-879X 1414-431X http://hdl.handle.net/11449/211264 10.1590/1414-431X20132964 S0100-879X2013001000824 S0100-879X2013001000824.pdf |
url |
http://dx.doi.org/10.1590/1414-431X20132964 http://hdl.handle.net/11449/211264 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 46, n. 10, p. 824-830, 2013. 0100-879X 1414-431X 10.1590/1414-431X20132964 S0100-879X2013001000824 S0100-879X2013001000824.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
824-830 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965565666721792 |