Multidrug resistant bacteria isolated from septic arthritis in horses
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-736X2017000400005 http://hdl.handle.net/11449/175036 |
Resumo: | Septic arthritis is a debilitating joint infectious disease of equines that requires early diagnosis and immediate therapeutic intervention to prevent degenerative effects on the articular cartilage, as well as loss of athletic ability and work performance of the animals. Few studies have investigated the etiological complexity of this disease, as well as multidrug resistance of isolates. In this study, 60 horses with arthritis had synovial fluid samples aseptically collected, and tested by microbiological culture and in vitro susceptibility test (disk diffusion) using nine antimicrobials belonging to six different pharmacological groups. Bacteria were isolated in 45 (75.0%) samples, as follows: Streptococcus equi subsp. equi (11=18.3%), Escherichia coli (9=15.0%), Staphylococcus aureus (6=10.0%), Streptococcus equi subsp. zooepidemicus (5=8.3%), Staphylococcus intermedius (2=3.3%), Proteus vulgaris (2=3.3%), Trueperella pyogenes (2=3.3%), Pseudomonas aeruginosa (2=3.3%), Klebsiella pneumoniae (1=1.7%), Rhodococcus equi (1=1.7%), Staphylococcus epidermidis (1=1.7%), Klebsiella oxytoca (1=1.7%), Nocardia asteroides (1=1.7%), and Enterobacter cloacae (1=1.7%). Ceftiofur was the most effective drug (> 70% efficacy) against the pathogens in the disk diffusion test. In contrast, high resistance rate (> 70% resistance) was observed to penicillin (42.2%), enrofloxacin (33.3%), and amikacin (31.2%). Eleven (24.4%) isolates were resistant to three or more different pharmacological groups and were considered multidrug resistant strains. The present study emphasizes the etiological complexity of equine septic arthritis, and highlights the need to institute treatment based on the in vitro susceptibility pattern, due to the multidrug resistance of isolates. According to the available literature, this is the first report in Brazil on the investigation of the etiology. of the septic arthritis in a great number of horses associated with multidrug resistance of the isolates. |
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Multidrug resistant bacteria isolated from septic arthritis in horsesAntimicrobial resistanceArthritisEtiologyHorsesJoint infectious diseasesSeptic arthritis is a debilitating joint infectious disease of equines that requires early diagnosis and immediate therapeutic intervention to prevent degenerative effects on the articular cartilage, as well as loss of athletic ability and work performance of the animals. Few studies have investigated the etiological complexity of this disease, as well as multidrug resistance of isolates. In this study, 60 horses with arthritis had synovial fluid samples aseptically collected, and tested by microbiological culture and in vitro susceptibility test (disk diffusion) using nine antimicrobials belonging to six different pharmacological groups. Bacteria were isolated in 45 (75.0%) samples, as follows: Streptococcus equi subsp. equi (11=18.3%), Escherichia coli (9=15.0%), Staphylococcus aureus (6=10.0%), Streptococcus equi subsp. zooepidemicus (5=8.3%), Staphylococcus intermedius (2=3.3%), Proteus vulgaris (2=3.3%), Trueperella pyogenes (2=3.3%), Pseudomonas aeruginosa (2=3.3%), Klebsiella pneumoniae (1=1.7%), Rhodococcus equi (1=1.7%), Staphylococcus epidermidis (1=1.7%), Klebsiella oxytoca (1=1.7%), Nocardia asteroides (1=1.7%), and Enterobacter cloacae (1=1.7%). Ceftiofur was the most effective drug (> 70% efficacy) against the pathogens in the disk diffusion test. In contrast, high resistance rate (> 70% resistance) was observed to penicillin (42.2%), enrofloxacin (33.3%), and amikacin (31.2%). Eleven (24.4%) isolates were resistant to three or more different pharmacological groups and were considered multidrug resistant strains. The present study emphasizes the etiological complexity of equine septic arthritis, and highlights the need to institute treatment based on the in vitro susceptibility pattern, due to the multidrug resistance of isolates. According to the available literature, this is the first report in Brazil on the investigation of the etiology. of the septic arthritis in a great number of horses associated with multidrug resistance of the isolates.Departamento de Higiene Veterinária e Saúde Pública Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista (Unesp), Cx. Postal 560Departamento de Clínica Médica de Grandes Animais Universidade de Rio Verde (UniRV), Cx. Postal 104Programa de Pós-Graduação em Reprodução Animal Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade de São Pulo (USP), Cx. Postal 225Médica Veterinária Autônoma, Av. Panamericana, Carrera 13, dBarrio Ciudad JardinPós-doutor pela Mississippi State University USA. Department of Pathobiology and Population Medicine College of Veterinary MedicineDepartamento de Higiene Veterinária e Saúde Pública Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista (Unesp), Cx. Postal 560Universidade Estadual Paulista (Unesp)Universidade de Rio Verde (UniRV)Universidade de São Paulo (USP)Médica Veterinária AutônomaCollege of Veterinary MedicineMotta, Rodrigo G. [UNESP]Martins, Lorrayne S.A.Motta, Igor G.Guerra, Simony T. [UNESP]de Paula, Carolina L. [UNESP]Bolanos, Carmen Alicia Daza [UNESP]da Silva, Rodrigo CostaRibeiro, Marcio Garcia [UNESP]2018-12-11T17:13:56Z2018-12-11T17:13:56Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article325-330application/pdfhttp://dx.doi.org/10.1590/S0100-736X2017000400005Pesquisa Veterinaria Brasileira, v. 37, n. 4, p. 325-330, 2017.1678-51500100-736Xhttp://hdl.handle.net/11449/17503610.1590/S0100-736X2017000400005S0100-736X20170004003252-s2.0-85027318614S0100-736X2017000400325.pdf2209124317273797Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2023-11-26T06:11:34Zoai:repositorio.unesp.br:11449/175036Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-26T06:11:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Multidrug resistant bacteria isolated from septic arthritis in horses |
title |
Multidrug resistant bacteria isolated from septic arthritis in horses |
spellingShingle |
Multidrug resistant bacteria isolated from septic arthritis in horses Motta, Rodrigo G. [UNESP] Antimicrobial resistance Arthritis Etiology Horses Joint infectious diseases |
title_short |
Multidrug resistant bacteria isolated from septic arthritis in horses |
title_full |
Multidrug resistant bacteria isolated from septic arthritis in horses |
title_fullStr |
Multidrug resistant bacteria isolated from septic arthritis in horses |
title_full_unstemmed |
Multidrug resistant bacteria isolated from septic arthritis in horses |
title_sort |
Multidrug resistant bacteria isolated from septic arthritis in horses |
author |
Motta, Rodrigo G. [UNESP] |
author_facet |
Motta, Rodrigo G. [UNESP] Martins, Lorrayne S.A. Motta, Igor G. Guerra, Simony T. [UNESP] de Paula, Carolina L. [UNESP] Bolanos, Carmen Alicia Daza [UNESP] da Silva, Rodrigo Costa Ribeiro, Marcio Garcia [UNESP] |
author_role |
author |
author2 |
Martins, Lorrayne S.A. Motta, Igor G. Guerra, Simony T. [UNESP] de Paula, Carolina L. [UNESP] Bolanos, Carmen Alicia Daza [UNESP] da Silva, Rodrigo Costa Ribeiro, Marcio Garcia [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de Rio Verde (UniRV) Universidade de São Paulo (USP) Médica Veterinária Autônoma College of Veterinary Medicine |
dc.contributor.author.fl_str_mv |
Motta, Rodrigo G. [UNESP] Martins, Lorrayne S.A. Motta, Igor G. Guerra, Simony T. [UNESP] de Paula, Carolina L. [UNESP] Bolanos, Carmen Alicia Daza [UNESP] da Silva, Rodrigo Costa Ribeiro, Marcio Garcia [UNESP] |
dc.subject.por.fl_str_mv |
Antimicrobial resistance Arthritis Etiology Horses Joint infectious diseases |
topic |
Antimicrobial resistance Arthritis Etiology Horses Joint infectious diseases |
description |
Septic arthritis is a debilitating joint infectious disease of equines that requires early diagnosis and immediate therapeutic intervention to prevent degenerative effects on the articular cartilage, as well as loss of athletic ability and work performance of the animals. Few studies have investigated the etiological complexity of this disease, as well as multidrug resistance of isolates. In this study, 60 horses with arthritis had synovial fluid samples aseptically collected, and tested by microbiological culture and in vitro susceptibility test (disk diffusion) using nine antimicrobials belonging to six different pharmacological groups. Bacteria were isolated in 45 (75.0%) samples, as follows: Streptococcus equi subsp. equi (11=18.3%), Escherichia coli (9=15.0%), Staphylococcus aureus (6=10.0%), Streptococcus equi subsp. zooepidemicus (5=8.3%), Staphylococcus intermedius (2=3.3%), Proteus vulgaris (2=3.3%), Trueperella pyogenes (2=3.3%), Pseudomonas aeruginosa (2=3.3%), Klebsiella pneumoniae (1=1.7%), Rhodococcus equi (1=1.7%), Staphylococcus epidermidis (1=1.7%), Klebsiella oxytoca (1=1.7%), Nocardia asteroides (1=1.7%), and Enterobacter cloacae (1=1.7%). Ceftiofur was the most effective drug (> 70% efficacy) against the pathogens in the disk diffusion test. In contrast, high resistance rate (> 70% resistance) was observed to penicillin (42.2%), enrofloxacin (33.3%), and amikacin (31.2%). Eleven (24.4%) isolates were resistant to three or more different pharmacological groups and were considered multidrug resistant strains. The present study emphasizes the etiological complexity of equine septic arthritis, and highlights the need to institute treatment based on the in vitro susceptibility pattern, due to the multidrug resistance of isolates. According to the available literature, this is the first report in Brazil on the investigation of the etiology. of the septic arthritis in a great number of horses associated with multidrug resistance of the isolates. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T17:13:56Z 2018-12-11T17:13:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-736X2017000400005 Pesquisa Veterinaria Brasileira, v. 37, n. 4, p. 325-330, 2017. 1678-5150 0100-736X http://hdl.handle.net/11449/175036 10.1590/S0100-736X2017000400005 S0100-736X2017000400325 2-s2.0-85027318614 S0100-736X2017000400325.pdf 2209124317273797 |
url |
http://dx.doi.org/10.1590/S0100-736X2017000400005 http://hdl.handle.net/11449/175036 |
identifier_str_mv |
Pesquisa Veterinaria Brasileira, v. 37, n. 4, p. 325-330, 2017. 1678-5150 0100-736X 10.1590/S0100-736X2017000400005 S0100-736X2017000400325 2-s2.0-85027318614 S0100-736X2017000400325.pdf 2209124317273797 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Veterinaria Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
325-330 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965074300862464 |