Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdx
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng spa |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4067/S0717-95022011000400048 http://hdl.handle.net/11449/226750 |
Resumo: | Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressive loss of muscular strength. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stability. The aim of this study was to verify the possible protective anti-inflammatory effect of citrus oil on mdx muscle fibers. Thus, adult male and female mdx mice (014/06-CEEA) were divided into control and citrus-treated. After 60 days of treatment, one ml of blood was collected for creatine kinase (CK) test. Diaphragm, sternomastoideus, anterior tibial and gastrocnemius muscles were removed and processed according to histological routine methods. The observed alterations indicate a direct effect of citrus. Recent studies have improved the diagnosis of muscular diseases but with no definitions of efficient treatments. Intervention with several therapies is important to many patients presenting muscular dystrophy, which enables them to live longer and be more active, while there is no development of gene therapies. |
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Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdxEffect of Citrus aurantium L. essential oil on muscle regeneration in mdx miceCentral nucleiCitrus aurantium L.Creatine kinaseDuchenne muscular dystrophyMdx mouseMuscle fiberMuscle regenerationDuchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressive loss of muscular strength. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stability. The aim of this study was to verify the possible protective anti-inflammatory effect of citrus oil on mdx muscle fibers. Thus, adult male and female mdx mice (014/06-CEEA) were divided into control and citrus-treated. After 60 days of treatment, one ml of blood was collected for creatine kinase (CK) test. Diaphragm, sternomastoideus, anterior tibial and gastrocnemius muscles were removed and processed according to histological routine methods. The observed alterations indicate a direct effect of citrus. Recent studies have improved the diagnosis of muscular diseases but with no definitions of efficient treatments. Intervention with several therapies is important to many patients presenting muscular dystrophy, which enables them to live longer and be more active, while there is no development of gene therapies.Department of Morphology Institute of Biosciences São Paulo State University (UNESP), Botucatu Municipality, São Paulo StateDepartment of Anatomy Institute of Biology State University of Campinas (UNICAMP), Campinas Municipality, São Paulo StateDepartment of Physiology Institute of Biosciences São Paulo State University (UNESP), Botucatu Municipality, São Paulo StateDepartment of Morphology Institute of Biosciences São Paulo State University (UNESP), Botucatu Municipality, São Paulo StateDepartment of Physiology Institute of Biosciences São Paulo State University (UNESP), Botucatu Municipality, São Paulo StateUniversidade Estadual Paulista (UNESP)Universidade Estadual de Campinas (UNICAMP)de Souza, Paula Aiello Tomé [UNESP]Marques, Maria JúliaLima, Clélia Akiko Hiruma [UNESP]Matheus, Selma Maria Michelin2022-04-29T02:55:21Z2022-04-29T02:55:21Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1357-1363http://dx.doi.org/10.4067/S0717-95022011000400048International Journal of Morphology, v. 29, n. 4, p. 1357-1363, 2011.0717-95020717-9367http://hdl.handle.net/11449/22675010.4067/S0717-950220110004000482-s2.0-84858757784Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengspaInternational Journal of Morphologyinfo:eu-repo/semantics/openAccess2022-04-29T02:55:21Zoai:repositorio.unesp.br:11449/226750Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:03:46.356163Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdx Effect of Citrus aurantium L. essential oil on muscle regeneration in mdx mice |
title |
Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdx |
spellingShingle |
Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdx de Souza, Paula Aiello Tomé [UNESP] Central nuclei Citrus aurantium L. Creatine kinase Duchenne muscular dystrophy Mdx mouse Muscle fiber Muscle regeneration |
title_short |
Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdx |
title_full |
Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdx |
title_fullStr |
Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdx |
title_full_unstemmed |
Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdx |
title_sort |
Efecto del aceite esencial de Citrus aurantium L. en la regeneración muscular en ratones mdx |
author |
de Souza, Paula Aiello Tomé [UNESP] |
author_facet |
de Souza, Paula Aiello Tomé [UNESP] Marques, Maria Júlia Lima, Clélia Akiko Hiruma [UNESP] Matheus, Selma Maria Michelin |
author_role |
author |
author2 |
Marques, Maria Júlia Lima, Clélia Akiko Hiruma [UNESP] Matheus, Selma Maria Michelin |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
de Souza, Paula Aiello Tomé [UNESP] Marques, Maria Júlia Lima, Clélia Akiko Hiruma [UNESP] Matheus, Selma Maria Michelin |
dc.subject.por.fl_str_mv |
Central nuclei Citrus aurantium L. Creatine kinase Duchenne muscular dystrophy Mdx mouse Muscle fiber Muscle regeneration |
topic |
Central nuclei Citrus aurantium L. Creatine kinase Duchenne muscular dystrophy Mdx mouse Muscle fiber Muscle regeneration |
description |
Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressive loss of muscular strength. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stability. The aim of this study was to verify the possible protective anti-inflammatory effect of citrus oil on mdx muscle fibers. Thus, adult male and female mdx mice (014/06-CEEA) were divided into control and citrus-treated. After 60 days of treatment, one ml of blood was collected for creatine kinase (CK) test. Diaphragm, sternomastoideus, anterior tibial and gastrocnemius muscles were removed and processed according to histological routine methods. The observed alterations indicate a direct effect of citrus. Recent studies have improved the diagnosis of muscular diseases but with no definitions of efficient treatments. Intervention with several therapies is important to many patients presenting muscular dystrophy, which enables them to live longer and be more active, while there is no development of gene therapies. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 2022-04-29T02:55:21Z 2022-04-29T02:55:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4067/S0717-95022011000400048 International Journal of Morphology, v. 29, n. 4, p. 1357-1363, 2011. 0717-9502 0717-9367 http://hdl.handle.net/11449/226750 10.4067/S0717-95022011000400048 2-s2.0-84858757784 |
url |
http://dx.doi.org/10.4067/S0717-95022011000400048 http://hdl.handle.net/11449/226750 |
identifier_str_mv |
International Journal of Morphology, v. 29, n. 4, p. 1357-1363, 2011. 0717-9502 0717-9367 10.4067/S0717-95022011000400048 2-s2.0-84858757784 |
dc.language.iso.fl_str_mv |
eng spa |
language |
eng spa |
dc.relation.none.fl_str_mv |
International Journal of Morphology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1357-1363 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128310261055488 |