Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1021/acsapm.1c01437 http://hdl.handle.net/11449/241721 |
Resumo: | Bacterial cellulose nanocrystals (BCNC) stand out as versatile biocolloidal building blocks for materials that are high-performance, owing to their inherently high crystallinity and specific modulus and surface area, and sustainable, as BCNC are both biobased and biodegradable. BCNC materials are also promising for their multifunctionality because of their huge potential to undergo physical and/or chemical surface modification. This is particularly appealing for biomedical applications thanks to the biocompatibility, high purity, and low toxicity of BCNC. We report on films based on surface-modified BCNC with varying contents of 3-glycidyloxypropyltrimethoxysilane (GPTMS) or 3-aminopropyltriethoxysilane (APTS). Importantly, these highly pure and crystalline needle-shaped BCNC were isolated from scraps generated at industrial operations when shaping bacterial cellulose membranes into wound dressings. The films were extensively characterized as far as their structural characteristics, with emphasis on the major features targeting at biological applications. Compared with pristine BCNC, the films performed better from the thermal stability standpoint and maintained the noncytotoxicity against nontransforming fibroblasts. The latter claim was independent of GPTMS content, but dose-dependent for APTS and valid for films containing up to 30% of this coupling agent. Altogether, this contribution expands the wingspan of nanocellulose-based materials in biomedical applications while mitigating the waste of natural resources by upcycling an industrial byproduct, falling within the circular bioeconomy framework. |
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Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystalsbiocellulosecellulose nanowhiskershybridsmicrobial cellulosesiloxanesupcyclingBacterial cellulose nanocrystals (BCNC) stand out as versatile biocolloidal building blocks for materials that are high-performance, owing to their inherently high crystallinity and specific modulus and surface area, and sustainable, as BCNC are both biobased and biodegradable. BCNC materials are also promising for their multifunctionality because of their huge potential to undergo physical and/or chemical surface modification. This is particularly appealing for biomedical applications thanks to the biocompatibility, high purity, and low toxicity of BCNC. We report on films based on surface-modified BCNC with varying contents of 3-glycidyloxypropyltrimethoxysilane (GPTMS) or 3-aminopropyltriethoxysilane (APTS). Importantly, these highly pure and crystalline needle-shaped BCNC were isolated from scraps generated at industrial operations when shaping bacterial cellulose membranes into wound dressings. The films were extensively characterized as far as their structural characteristics, with emphasis on the major features targeting at biological applications. Compared with pristine BCNC, the films performed better from the thermal stability standpoint and maintained the noncytotoxicity against nontransforming fibroblasts. The latter claim was independent of GPTMS content, but dose-dependent for APTS and valid for films containing up to 30% of this coupling agent. Altogether, this contribution expands the wingspan of nanocellulose-based materials in biomedical applications while mitigating the waste of natural resources by upcycling an industrial byproduct, falling within the circular bioeconomy framework.Department of Chemistry Federal University of Maranhão - UFMA, MaranhãoDepartment of Chemistry Federal University of São Carlos - UFSCar, São PauloBiopolymers and Biomaterials Laboratory (BioPolMat) University of Araraquara - UNIARA, São PauloSchool of Pharmaceutical Sciences São Paulo State University - UNESP, São PauloDepartment of Physics Federal University of Maranhão - UFMA, MaranhãoMutagenisis Laboratory University of Araraquara - UNIARA, São PauloDepartment of Chemistry Faculty of Philosophy Sciences and Letters at Ribeirão Preto (FFCLRP) University of São Paulo - USP, São PauloChemistry Institute São Paulo State University - UNESP, São PauloDepartment of Materials Engineering - DEMa Federal University of São Carlos - UFSCar, São PauloSchool of Pharmaceutical Sciences São Paulo State University - UNESP, São PauloChemistry Institute São Paulo State University - UNESP, São PauloFederal University of Maranhão - UFMAUniversidade Federal de São Carlos (UFSCar)University of Araraquara - UNIARAUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Lima, Lais R.Conte, Gabriela V.Brandão, Larissa R.Sábio, Rafael M. [UNESP]De Menezes, Alan S.Resende, Flávia AparecidaCaiut, José M. A.Ribeiro, Sidney J. L. [UNESP]Otoni, Caio G.Alcântara, Ana C. S.Barud, Hernane Da S.2023-03-01T21:18:24Z2023-03-01T21:18:24Z2022-04-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2306-2313http://dx.doi.org/10.1021/acsapm.1c01437ACS Applied Polymer Materials, v. 4, n. 4, p. 2306-2313, 2022.2637-6105http://hdl.handle.net/11449/24172110.1021/acsapm.1c014372-s2.0-85127959483Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengACS Applied Polymer Materialsinfo:eu-repo/semantics/openAccess2023-03-01T21:18:24Zoai:repositorio.unesp.br:11449/241721Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:43:45.826815Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals |
title |
Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals |
spellingShingle |
Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals Lima, Lais R. biocellulose cellulose nanowhiskers hybrids microbial cellulose siloxanes upcycling |
title_short |
Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals |
title_full |
Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals |
title_fullStr |
Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals |
title_full_unstemmed |
Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals |
title_sort |
Fabrication of Noncytotoxic Functional Siloxane-Coated Bacterial Cellulose Nanocrystals |
author |
Lima, Lais R. |
author_facet |
Lima, Lais R. Conte, Gabriela V. Brandão, Larissa R. Sábio, Rafael M. [UNESP] De Menezes, Alan S. Resende, Flávia Aparecida Caiut, José M. A. Ribeiro, Sidney J. L. [UNESP] Otoni, Caio G. Alcântara, Ana C. S. Barud, Hernane Da S. |
author_role |
author |
author2 |
Conte, Gabriela V. Brandão, Larissa R. Sábio, Rafael M. [UNESP] De Menezes, Alan S. Resende, Flávia Aparecida Caiut, José M. A. Ribeiro, Sidney J. L. [UNESP] Otoni, Caio G. Alcântara, Ana C. S. Barud, Hernane Da S. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Maranhão - UFMA Universidade Federal de São Carlos (UFSCar) University of Araraquara - UNIARA Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Lima, Lais R. Conte, Gabriela V. Brandão, Larissa R. Sábio, Rafael M. [UNESP] De Menezes, Alan S. Resende, Flávia Aparecida Caiut, José M. A. Ribeiro, Sidney J. L. [UNESP] Otoni, Caio G. Alcântara, Ana C. S. Barud, Hernane Da S. |
dc.subject.por.fl_str_mv |
biocellulose cellulose nanowhiskers hybrids microbial cellulose siloxanes upcycling |
topic |
biocellulose cellulose nanowhiskers hybrids microbial cellulose siloxanes upcycling |
description |
Bacterial cellulose nanocrystals (BCNC) stand out as versatile biocolloidal building blocks for materials that are high-performance, owing to their inherently high crystallinity and specific modulus and surface area, and sustainable, as BCNC are both biobased and biodegradable. BCNC materials are also promising for their multifunctionality because of their huge potential to undergo physical and/or chemical surface modification. This is particularly appealing for biomedical applications thanks to the biocompatibility, high purity, and low toxicity of BCNC. We report on films based on surface-modified BCNC with varying contents of 3-glycidyloxypropyltrimethoxysilane (GPTMS) or 3-aminopropyltriethoxysilane (APTS). Importantly, these highly pure and crystalline needle-shaped BCNC were isolated from scraps generated at industrial operations when shaping bacterial cellulose membranes into wound dressings. The films were extensively characterized as far as their structural characteristics, with emphasis on the major features targeting at biological applications. Compared with pristine BCNC, the films performed better from the thermal stability standpoint and maintained the noncytotoxicity against nontransforming fibroblasts. The latter claim was independent of GPTMS content, but dose-dependent for APTS and valid for films containing up to 30% of this coupling agent. Altogether, this contribution expands the wingspan of nanocellulose-based materials in biomedical applications while mitigating the waste of natural resources by upcycling an industrial byproduct, falling within the circular bioeconomy framework. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-08 2023-03-01T21:18:24Z 2023-03-01T21:18:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1021/acsapm.1c01437 ACS Applied Polymer Materials, v. 4, n. 4, p. 2306-2313, 2022. 2637-6105 http://hdl.handle.net/11449/241721 10.1021/acsapm.1c01437 2-s2.0-85127959483 |
url |
http://dx.doi.org/10.1021/acsapm.1c01437 http://hdl.handle.net/11449/241721 |
identifier_str_mv |
ACS Applied Polymer Materials, v. 4, n. 4, p. 2306-2313, 2022. 2637-6105 10.1021/acsapm.1c01437 2-s2.0-85127959483 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
ACS Applied Polymer Materials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2306-2313 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128692672528384 |