Hiperplasia gengival associada ao uso de medicamentos anticonvulsivantes: revisão sistemática

• Autor(a) principal: Cláudio, Marina Módolo [UNESP]
• Data de Publicação: 2015
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149702; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-31/000867939.pdf
• topic: Hiperplasia gengival; Anticonvulsivantes; Prevalência; Gingival hyperplasia

Gingival Hyperplasia associated with the use of medicines is an adverse effect of systemic drug treatment caused by three classes of drugs, anticonvulsants, immunosuppressants and calcium channel blockers. The objective of this study was to conduct a systematic review of the literature to ascertain the prevalence of Gingival Hyperplasia associated with the use of anticonvulsants and the main drug that leads to this clinical picture. A search was done on Pubmed database, using the words phenytoin, anticonvulsants, gingival overgrowth and gingival hyperplasia. After the collection of the articles, they were evaluated by two reviewers, who have selected the articles according to the following criteria: controlled clinical studies; prospective and retrospective studies and studies that evaluated the prevalence of Gingival Hyperplasia associated with the use of anticonvulsants. At the end were selected 8 articles, which showed prevalence gingival hyperplasia, ranging from 0 to 76%. It is concluded that one of the anticonvulsants used, phenytoin is the drug with a higher incidence of Gingival Hyperplasia associated with its use, varying their occurrence between 34.5% and 61.1% of the patients that use. However, studies are needed with a view to understanding the mechanism of action of drug induced gingival overgrowth of the, in addition to ways of preventing this increase, since gingival hyperplasia associated with the use of medicines remains a significant side effect, which is exacerbated by poor oral hygiene of patients with motor disabilities