The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00228-017-2243-1 http://hdl.handle.net/11449/169631 |
Resumo: | Purpose: Rocuronium (ROC) is a neuromuscular blocker mainly eliminated by biliary excretion dependent on organic anion transporting polypeptide 1A2 (OATP1A2) hepatocellular uptake. However, the influence of SLCO1A2 (gene encoding OATP1A2) genetic polymorphism on ROC pharmacokinetics was never described before. The objective of this work was to evaluate the influence of genetic polymorphisms of SLCO1A2 on the pharmacokinetics of rocuronium (ROC). Methods: Patients undergoing elective surgeries under general anesthesia using rocuronium as a neuromuscular blocker were genotyped for SLCO1A2 polymorphisms in the coding region (41A>G, 382A>T, 404A>T, 502C>T, 516A>C, 559G>A, 830C>A, and 833delA) and in the promoter region (-1105G>A, -1032G>A, -715T>C, -361G>A, and -189_-188insA). Rocuronium pharmacokinetic parameters were estimated by non-compartmental analysis. Results: None of the patients had heterozygous or homozygous variant of 404A>T, 382A>T, 502C>T, 833delA, 830C>A, 41A>G, and -715T>C. A linkage disequilibrium was found between -1105G>A and -1032G>A genotypes. Patients genotyped as -A or AA (n = 17) for SLCO1A2 -189_-188InsA showed reduced total clearance of ROC compared to patients genotyped as −/− (n = 13) (151.6 vs 207.1 mL/min, p ≤ 0.05). The pharmacokinetics parameters of ROC were not significantly different between other SLCO1A2 genotypes. Conclusion: SLCO1A2 -189_-188InsA polymorphism is related to the reduced clearance of rocuronium in patients submitted to elective surgeries under general anesthesia. Trial registration: NCT 02399397 (ClinicalTrials.gov). |
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Repositório Institucional da UNESP |
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The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeriesNeuromuscular blockadePharmacogeneticsPharmacokineticsRocuroniumSNPsPurpose: Rocuronium (ROC) is a neuromuscular blocker mainly eliminated by biliary excretion dependent on organic anion transporting polypeptide 1A2 (OATP1A2) hepatocellular uptake. However, the influence of SLCO1A2 (gene encoding OATP1A2) genetic polymorphism on ROC pharmacokinetics was never described before. The objective of this work was to evaluate the influence of genetic polymorphisms of SLCO1A2 on the pharmacokinetics of rocuronium (ROC). Methods: Patients undergoing elective surgeries under general anesthesia using rocuronium as a neuromuscular blocker were genotyped for SLCO1A2 polymorphisms in the coding region (41A>G, 382A>T, 404A>T, 502C>T, 516A>C, 559G>A, 830C>A, and 833delA) and in the promoter region (-1105G>A, -1032G>A, -715T>C, -361G>A, and -189_-188insA). Rocuronium pharmacokinetic parameters were estimated by non-compartmental analysis. Results: None of the patients had heterozygous or homozygous variant of 404A>T, 382A>T, 502C>T, 833delA, 830C>A, 41A>G, and -715T>C. A linkage disequilibrium was found between -1105G>A and -1032G>A genotypes. Patients genotyped as -A or AA (n = 17) for SLCO1A2 -189_-188InsA showed reduced total clearance of ROC compared to patients genotyped as −/− (n = 13) (151.6 vs 207.1 mL/min, p ≤ 0.05). The pharmacokinetics parameters of ROC were not significantly different between other SLCO1A2 genotypes. Conclusion: SLCO1A2 -189_-188InsA polymorphism is related to the reduced clearance of rocuronium in patients submitted to elective surgeries under general anesthesia. Trial registration: NCT 02399397 (ClinicalTrials.gov).Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade de São Paulo (USP) Faculdade de Ciências Farmacêuticas de Ribeirão PretoUniversidade de São Paulo (USP) Faculdade de Medicina de Ribeirão PretoUniversidade Estadual Paulista (UNESP) Faculdade de Ciências FarmacêuticasUniversidade Estadual Paulista (UNESP) Faculdade de Ciências FarmacêuticasFAPESP: 2013/14730-0Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Costa, A. C.C.Coelho, E. B.Lanchote, V. L.Correia, B. V. [UNESP]Abumansur, J. T.Lauretti, G. R.de Moraes, N. V. [UNESP]2018-12-11T16:46:56Z2018-12-11T16:46:56Z2017-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article957-963application/pdfhttp://dx.doi.org/10.1007/s00228-017-2243-1European Journal of Clinical Pharmacology, v. 73, n. 8, p. 957-963, 2017.1432-10410031-6970http://hdl.handle.net/11449/16963110.1007/s00228-017-2243-12-s2.0-850174451152-s2.0-85017445115.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Clinical Pharmacology1,1591,159info:eu-repo/semantics/openAccess2023-12-15T06:21:38Zoai:repositorio.unesp.br:11449/169631Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-15T06:21:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries |
title |
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries |
spellingShingle |
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries Costa, A. C.C. Neuromuscular blockade Pharmacogenetics Pharmacokinetics Rocuronium SNPs |
title_short |
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries |
title_full |
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries |
title_fullStr |
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries |
title_full_unstemmed |
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries |
title_sort |
The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries |
author |
Costa, A. C.C. |
author_facet |
Costa, A. C.C. Coelho, E. B. Lanchote, V. L. Correia, B. V. [UNESP] Abumansur, J. T. Lauretti, G. R. de Moraes, N. V. [UNESP] |
author_role |
author |
author2 |
Coelho, E. B. Lanchote, V. L. Correia, B. V. [UNESP] Abumansur, J. T. Lauretti, G. R. de Moraes, N. V. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Costa, A. C.C. Coelho, E. B. Lanchote, V. L. Correia, B. V. [UNESP] Abumansur, J. T. Lauretti, G. R. de Moraes, N. V. [UNESP] |
dc.subject.por.fl_str_mv |
Neuromuscular blockade Pharmacogenetics Pharmacokinetics Rocuronium SNPs |
topic |
Neuromuscular blockade Pharmacogenetics Pharmacokinetics Rocuronium SNPs |
description |
Purpose: Rocuronium (ROC) is a neuromuscular blocker mainly eliminated by biliary excretion dependent on organic anion transporting polypeptide 1A2 (OATP1A2) hepatocellular uptake. However, the influence of SLCO1A2 (gene encoding OATP1A2) genetic polymorphism on ROC pharmacokinetics was never described before. The objective of this work was to evaluate the influence of genetic polymorphisms of SLCO1A2 on the pharmacokinetics of rocuronium (ROC). Methods: Patients undergoing elective surgeries under general anesthesia using rocuronium as a neuromuscular blocker were genotyped for SLCO1A2 polymorphisms in the coding region (41A>G, 382A>T, 404A>T, 502C>T, 516A>C, 559G>A, 830C>A, and 833delA) and in the promoter region (-1105G>A, -1032G>A, -715T>C, -361G>A, and -189_-188insA). Rocuronium pharmacokinetic parameters were estimated by non-compartmental analysis. Results: None of the patients had heterozygous or homozygous variant of 404A>T, 382A>T, 502C>T, 833delA, 830C>A, 41A>G, and -715T>C. A linkage disequilibrium was found between -1105G>A and -1032G>A genotypes. Patients genotyped as -A or AA (n = 17) for SLCO1A2 -189_-188InsA showed reduced total clearance of ROC compared to patients genotyped as −/− (n = 13) (151.6 vs 207.1 mL/min, p ≤ 0.05). The pharmacokinetics parameters of ROC were not significantly different between other SLCO1A2 genotypes. Conclusion: SLCO1A2 -189_-188InsA polymorphism is related to the reduced clearance of rocuronium in patients submitted to elective surgeries under general anesthesia. Trial registration: NCT 02399397 (ClinicalTrials.gov). |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-01 2018-12-11T16:46:56Z 2018-12-11T16:46:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00228-017-2243-1 European Journal of Clinical Pharmacology, v. 73, n. 8, p. 957-963, 2017. 1432-1041 0031-6970 http://hdl.handle.net/11449/169631 10.1007/s00228-017-2243-1 2-s2.0-85017445115 2-s2.0-85017445115.pdf |
url |
http://dx.doi.org/10.1007/s00228-017-2243-1 http://hdl.handle.net/11449/169631 |
identifier_str_mv |
European Journal of Clinical Pharmacology, v. 73, n. 8, p. 957-963, 2017. 1432-1041 0031-6970 10.1007/s00228-017-2243-1 2-s2.0-85017445115 2-s2.0-85017445115.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal of Clinical Pharmacology 1,159 1,159 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
957-963 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803649996914950144 |