Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systems

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Sabrina Dias
Data de Publicação: 2016
Outros Autores: Guimes, Rodrigues Filho, Meneguin, Andreia Bagliotti [UNESP], Prezotti, Fabiola Garavello [UNESP], Boni, Fernanda Isadora [UNESP], Ferreira Cury, Beatriz Stringhetti [UNESP], Daflon Gremiao, Maria Palmira [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.carbpol.2016.07.069
http://hdl.handle.net/11449/159016
Resumo: Cellulose triacetate (CTA) films were produced from cellulose extracted from sugarcane bagasse. The films were characterized using scanning electron microscopy (SEM), water vapor permeability (WVP), mechanical properties (MP), enzymatic digestion (ED), and mucoadhesive properties evaluation (MPE). WVP showed that more concentrated films have higher values; asymmetric films had higher values than symmetric films. MP showed that symmetric membranes are more resistant than asymmetric ones. All films presented high mucoadhesiveness. From the WVP and MP results, a symmetric membrane with 6.5% CTA was selected for the coating of gellan gum (GG) particles incorporating ketoprofen (KET). Thermogravimetric analysis (TGA) showed that the CTA coating does not influence the thermal stability of the particles. Coated particles released 100% of the KET in 24 h, while uncoated particles released the same amount in 4 h. The results highlight the CTA potential in the development of new controlled oral delivery systems. (C) 2016 Elsevier Ltd. All rights reserved.
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spelling Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systemsCellulose triacetateGellan gumCoatingMucoadhesiveControlled releaseKetoprofenCellulose triacetate (CTA) films were produced from cellulose extracted from sugarcane bagasse. The films were characterized using scanning electron microscopy (SEM), water vapor permeability (WVP), mechanical properties (MP), enzymatic digestion (ED), and mucoadhesive properties evaluation (MPE). WVP showed that more concentrated films have higher values; asymmetric films had higher values than symmetric films. MP showed that symmetric membranes are more resistant than asymmetric ones. All films presented high mucoadhesiveness. From the WVP and MP results, a symmetric membrane with 6.5% CTA was selected for the coating of gellan gum (GG) particles incorporating ketoprofen (KET). Thermogravimetric analysis (TGA) showed that the CTA coating does not influence the thermal stability of the particles. Coated particles released 100% of the KET in 24 h, while uncoated particles released the same amount in 4 h. The results highlight the CTA potential in the development of new controlled oral delivery systems. (C) 2016 Elsevier Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Fed Uberlandia, Inst Chem, Uberlandia, MG, BrazilUniv Fed Uberlandia, Integrated Sci Coll Pontal FACIP, Ituiutaba, MG, BrazilState Univ Paulista Julio de Mesquita Filho, Sao Paulo, BrazilState Univ Paulista Julio de Mesquita Filho, Sao Paulo, BrazilFAPEMIG: CEX-APQ-01128/13Elsevier B.V.Universidade Federal de Uberlândia (UFU)Universidade Estadual Paulista (Unesp)Ribeiro, Sabrina DiasGuimes, Rodrigues FilhoMeneguin, Andreia Bagliotti [UNESP]Prezotti, Fabiola Garavello [UNESP]Boni, Fernanda Isadora [UNESP]Ferreira Cury, Beatriz Stringhetti [UNESP]Daflon Gremiao, Maria Palmira [UNESP]2018-11-26T15:30:47Z2018-11-26T15:30:47Z2016-11-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article764-774application/pdfhttp://dx.doi.org/10.1016/j.carbpol.2016.07.069Carbohydrate Polymers. Oxford: Elsevier Sci Ltd, v. 152, p. 764-774, 2016.0144-8617http://hdl.handle.net/11449/15901610.1016/j.carbpol.2016.07.069WOS:000380944500086WOS000380944500086.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCarbohydrate Polymers1,428info:eu-repo/semantics/openAccess2023-12-08T06:17:52Zoai:repositorio.unesp.br:11449/159016Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:45:26.920399Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systems
title Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systems
spellingShingle Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systems
Ribeiro, Sabrina Dias
Cellulose triacetate
Gellan gum
Coating
Mucoadhesive
Controlled release
Ketoprofen
title_short Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systems
title_full Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systems
title_fullStr Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systems
title_full_unstemmed Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systems
title_sort Cellulose triacetate films obtained from sugarcane bagasse: Evaluation as coating and mucoadhesive material for drug delivery systems
author Ribeiro, Sabrina Dias
author_facet Ribeiro, Sabrina Dias
Guimes, Rodrigues Filho
Meneguin, Andreia Bagliotti [UNESP]
Prezotti, Fabiola Garavello [UNESP]
Boni, Fernanda Isadora [UNESP]
Ferreira Cury, Beatriz Stringhetti [UNESP]
Daflon Gremiao, Maria Palmira [UNESP]
author_role author
author2 Guimes, Rodrigues Filho
Meneguin, Andreia Bagliotti [UNESP]
Prezotti, Fabiola Garavello [UNESP]
Boni, Fernanda Isadora [UNESP]
Ferreira Cury, Beatriz Stringhetti [UNESP]
Daflon Gremiao, Maria Palmira [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Uberlândia (UFU)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ribeiro, Sabrina Dias
Guimes, Rodrigues Filho
Meneguin, Andreia Bagliotti [UNESP]
Prezotti, Fabiola Garavello [UNESP]
Boni, Fernanda Isadora [UNESP]
Ferreira Cury, Beatriz Stringhetti [UNESP]
Daflon Gremiao, Maria Palmira [UNESP]
dc.subject.por.fl_str_mv Cellulose triacetate
Gellan gum
Coating
Mucoadhesive
Controlled release
Ketoprofen
topic Cellulose triacetate
Gellan gum
Coating
Mucoadhesive
Controlled release
Ketoprofen
description Cellulose triacetate (CTA) films were produced from cellulose extracted from sugarcane bagasse. The films were characterized using scanning electron microscopy (SEM), water vapor permeability (WVP), mechanical properties (MP), enzymatic digestion (ED), and mucoadhesive properties evaluation (MPE). WVP showed that more concentrated films have higher values; asymmetric films had higher values than symmetric films. MP showed that symmetric membranes are more resistant than asymmetric ones. All films presented high mucoadhesiveness. From the WVP and MP results, a symmetric membrane with 6.5% CTA was selected for the coating of gellan gum (GG) particles incorporating ketoprofen (KET). Thermogravimetric analysis (TGA) showed that the CTA coating does not influence the thermal stability of the particles. Coated particles released 100% of the KET in 24 h, while uncoated particles released the same amount in 4 h. The results highlight the CTA potential in the development of new controlled oral delivery systems. (C) 2016 Elsevier Ltd. All rights reserved.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-05
2018-11-26T15:30:47Z
2018-11-26T15:30:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.carbpol.2016.07.069
Carbohydrate Polymers. Oxford: Elsevier Sci Ltd, v. 152, p. 764-774, 2016.
0144-8617
http://hdl.handle.net/11449/159016
10.1016/j.carbpol.2016.07.069
WOS:000380944500086
WOS000380944500086.pdf
url http://dx.doi.org/10.1016/j.carbpol.2016.07.069
http://hdl.handle.net/11449/159016
identifier_str_mv Carbohydrate Polymers. Oxford: Elsevier Sci Ltd, v. 152, p. 764-774, 2016.
0144-8617
10.1016/j.carbpol.2016.07.069
WOS:000380944500086
WOS000380944500086.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Carbohydrate Polymers
1,428
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 764-774
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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