Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndrome

Detalhes bibliográficos
Autor(a) principal: de Alencar Britto, Revilane Parente
Data de Publicação: 2019
Outros Autores: Veiga, Rogério da Silva, Marcucci, Maria Cristina [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/198555
Resumo: Over the last three decades, the interest of the scientific community in investigating the use of saffron (Crocus sativus L.) as a potential therapeutic or preventive agent for a number of health conditions has increased. The purpose of this review is to examine the therapeutic role of saffron and its products in cardioprotection, atherosclerosis, dyslipidemia, systemic arterial hypertension (HAS), diabetes, insulin resistance and obesity. Most of the therapeutic properties of saffron are due to the presence of carotenoids (crocin, crocetin and safranal) playing an important antioxidant and anti-inflammatory role, suppressing pro-inflammatory cytokines and reactive oxygen species, reducing oxidative stress, peroxidation lipid metabolism, endothelial dysfunction, atherosclerosis, hypertension, dyslipidemia, insulin resistance and appetite. Further evidence is needed to investigate the benefits and molecular mechanisms of action, doses, and toxicity of saffron and its constituents in humans.
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spelling Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndromePotencial terapéutico del azafrán {Crocus sativus L.) en el síndrome metabólicoPotencial terapêutico do açafrão (Crocus sativus L.) na síndrome metabólicaAnti-inflammatoryAntioxidantsCardiovascular diseaseCrocus sativusMetabolic syndromeSaffronOver the last three decades, the interest of the scientific community in investigating the use of saffron (Crocus sativus L.) as a potential therapeutic or preventive agent for a number of health conditions has increased. The purpose of this review is to examine the therapeutic role of saffron and its products in cardioprotection, atherosclerosis, dyslipidemia, systemic arterial hypertension (HAS), diabetes, insulin resistance and obesity. Most of the therapeutic properties of saffron are due to the presence of carotenoids (crocin, crocetin and safranal) playing an important antioxidant and anti-inflammatory role, suppressing pro-inflammatory cytokines and reactive oxygen species, reducing oxidative stress, peroxidation lipid metabolism, endothelial dysfunction, atherosclerosis, hypertension, dyslipidemia, insulin resistance and appetite. Further evidence is needed to investigate the benefits and molecular mechanisms of action, doses, and toxicity of saffron and its constituents in humans.Centro de Recuperação e Educação Nutricional Hospital Geral do Estado Prof. Osvaldo Brandão VilelaFaculdade de Ciências Médicas da Santa Casa de São Paulo, R. Vila BuarqueDepartamento de Biopatologia Bucal Faculdade de Odontologia da UNESPDepartamento de Biopatologia Bucal Faculdade de Odontologia da UNESPHospital Geral do Estado Prof. Osvaldo Brandão VilelaFaculdade de Ciências Médicas da Santa Casa de São PauloUniversidade Estadual Paulista (Unesp)de Alencar Britto, Revilane ParenteVeiga, Rogério da SilvaMarcucci, Maria Cristina [UNESP]2020-12-12T01:16:04Z2020-12-12T01:16:04Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article139-147Revista de Fitoterapia, v. 18, n. 2, p. 139-147, 2019.1988-58061576-0952http://hdl.handle.net/11449/1985552-s2.0-85079851832Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista de Fitoterapiainfo:eu-repo/semantics/openAccess2021-10-22T16:05:43Zoai:repositorio.unesp.br:11449/198555Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:53:41.425644Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndrome
Potencial terapéutico del azafrán {Crocus sativus L.) en el síndrome metabólico
Potencial terapêutico do açafrão (Crocus sativus L.) na síndrome metabólica
title Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndrome
spellingShingle Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndrome
de Alencar Britto, Revilane Parente
Anti-inflammatory
Antioxidants
Cardiovascular disease
Crocus sativus
Metabolic syndrome
Saffron
title_short Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndrome
title_full Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndrome
title_fullStr Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndrome
title_full_unstemmed Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndrome
title_sort Potential therapeutic of saffron (Crocus sativus L.) in the metabolic syndrome
author de Alencar Britto, Revilane Parente
author_facet de Alencar Britto, Revilane Parente
Veiga, Rogério da Silva
Marcucci, Maria Cristina [UNESP]
author_role author
author2 Veiga, Rogério da Silva
Marcucci, Maria Cristina [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Hospital Geral do Estado Prof. Osvaldo Brandão Vilela
Faculdade de Ciências Médicas da Santa Casa de São Paulo
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv de Alencar Britto, Revilane Parente
Veiga, Rogério da Silva
Marcucci, Maria Cristina [UNESP]
dc.subject.por.fl_str_mv Anti-inflammatory
Antioxidants
Cardiovascular disease
Crocus sativus
Metabolic syndrome
Saffron
topic Anti-inflammatory
Antioxidants
Cardiovascular disease
Crocus sativus
Metabolic syndrome
Saffron
description Over the last three decades, the interest of the scientific community in investigating the use of saffron (Crocus sativus L.) as a potential therapeutic or preventive agent for a number of health conditions has increased. The purpose of this review is to examine the therapeutic role of saffron and its products in cardioprotection, atherosclerosis, dyslipidemia, systemic arterial hypertension (HAS), diabetes, insulin resistance and obesity. Most of the therapeutic properties of saffron are due to the presence of carotenoids (crocin, crocetin and safranal) playing an important antioxidant and anti-inflammatory role, suppressing pro-inflammatory cytokines and reactive oxygen species, reducing oxidative stress, peroxidation lipid metabolism, endothelial dysfunction, atherosclerosis, hypertension, dyslipidemia, insulin resistance and appetite. Further evidence is needed to investigate the benefits and molecular mechanisms of action, doses, and toxicity of saffron and its constituents in humans.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
2020-12-12T01:16:04Z
2020-12-12T01:16:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Revista de Fitoterapia, v. 18, n. 2, p. 139-147, 2019.
1988-5806
1576-0952
http://hdl.handle.net/11449/198555
2-s2.0-85079851832
identifier_str_mv Revista de Fitoterapia, v. 18, n. 2, p. 139-147, 2019.
1988-5806
1576-0952
2-s2.0-85079851832
url http://hdl.handle.net/11449/198555
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista de Fitoterapia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 139-147
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129136090152960

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