SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.21577/0100-4042.20170293 http://hdl.handle.net/11449/185128 |
Resumo: | The halide bridge cleavage reaction of the [Pd(C-2,N-bzox)(mu-Cl)](2). compound (bzox = benzaldehydeoxime) with ethylenethiourea (L) in the 1:2 molar ratio at room temperature yielded the cyclopalladated compound [Pd(C-2,N-bzox)(Cl)(L)] (1) whose replacement of the halide group by the addition of suitable salts afforded compounds of general formulae [Pd((C-2,N-bzox)(X)(L)] = {X = Br- (2), I-(3)}. All compounds were characterized by melting point, elemental analyses, infrared and H-1- and C-13{H-1}-NMR spectroscopies revealing the complexes formation with the oxime coordinated to Pd(II) as C,N-chelating and the ethylenethiourea as a monodentate ligand via the sulfur atom. Hie cytotoxicity of cyclopalladated compounds has been evaluated in vitro against murine mammary tumor cell (LM3) showing cytotoxic activity similar to cisplatin. |
id |
UNSP_ddeea0ea60e48232a161269ff2c99285 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/185128 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDScyclopalladated complexesoximesethylenethioureaimidazolidine-2-thionecytotoxicityThe halide bridge cleavage reaction of the [Pd(C-2,N-bzox)(mu-Cl)](2). compound (bzox = benzaldehydeoxime) with ethylenethiourea (L) in the 1:2 molar ratio at room temperature yielded the cyclopalladated compound [Pd(C-2,N-bzox)(Cl)(L)] (1) whose replacement of the halide group by the addition of suitable salts afforded compounds of general formulae [Pd((C-2,N-bzox)(X)(L)] = {X = Br- (2), I-(3)}. All compounds were characterized by melting point, elemental analyses, infrared and H-1- and C-13{H-1}-NMR spectroscopies revealing the complexes formation with the oxime coordinated to Pd(II) as C,N-chelating and the ethylenethiourea as a monodentate ligand via the sulfur atom. Hie cytotoxicity of cyclopalladated compounds has been evaluated in vitro against murine mammary tumor cell (LM3) showing cytotoxic activity similar to cisplatin.Univ Estadual Paulista, Dept Quim Geral & Inorgan, Inst Quim, BR-14800060 Araraquara, SP, BrazilUniv Estadual Paulista, Dept Anal Clin, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, BrazilUniv Estadual Paulista, Dept Quim Geral & Inorgan, Inst Quim, BR-14800060 Araraquara, SP, BrazilUniv Estadual Paulista, Dept Anal Clin, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, BrazilSoc Brasileira QuimicaUniversidade Estadual Paulista (Unesp)Thomazella, Nathalia A. [UNESP]Lemos, Sahra C. [UNESP]Souza, Ronan F. F. de [UNESP]Souza, Rodrigo A. de [UNESP]Mauro, Antonio E. [UNESP]Carlos, Iracilda Z. [UNESP]Netto, Adelino V. G. [UNESP]2019-10-04T12:32:48Z2019-10-04T12:32:48Z2018-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1150-1155application/pdfhttp://dx.doi.org/10.21577/0100-4042.20170293Quimica Nova. Sao Paulo: Soc Brasileira Quimica, v. 41, n. 10, p. 1150-1155, 2018.0100-4042http://hdl.handle.net/11449/18512810.21577/0100-4042.20170293S0100-40422018001001150WOS:000451630400008S0100-40422018001001150.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporQuimica Novainfo:eu-repo/semantics/openAccess2024-06-21T15:19:09Zoai:repositorio.unesp.br:11449/185128Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:22:47.895918Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS |
title |
SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS |
spellingShingle |
SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS Thomazella, Nathalia A. [UNESP] cyclopalladated complexes oximes ethylenethiourea imidazolidine-2-thione cytotoxicity |
title_short |
SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS |
title_full |
SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS |
title_fullStr |
SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS |
title_full_unstemmed |
SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS |
title_sort |
SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS |
author |
Thomazella, Nathalia A. [UNESP] |
author_facet |
Thomazella, Nathalia A. [UNESP] Lemos, Sahra C. [UNESP] Souza, Ronan F. F. de [UNESP] Souza, Rodrigo A. de [UNESP] Mauro, Antonio E. [UNESP] Carlos, Iracilda Z. [UNESP] Netto, Adelino V. G. [UNESP] |
author_role |
author |
author2 |
Lemos, Sahra C. [UNESP] Souza, Ronan F. F. de [UNESP] Souza, Rodrigo A. de [UNESP] Mauro, Antonio E. [UNESP] Carlos, Iracilda Z. [UNESP] Netto, Adelino V. G. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Thomazella, Nathalia A. [UNESP] Lemos, Sahra C. [UNESP] Souza, Ronan F. F. de [UNESP] Souza, Rodrigo A. de [UNESP] Mauro, Antonio E. [UNESP] Carlos, Iracilda Z. [UNESP] Netto, Adelino V. G. [UNESP] |
dc.subject.por.fl_str_mv |
cyclopalladated complexes oximes ethylenethiourea imidazolidine-2-thione cytotoxicity |
topic |
cyclopalladated complexes oximes ethylenethiourea imidazolidine-2-thione cytotoxicity |
description |
The halide bridge cleavage reaction of the [Pd(C-2,N-bzox)(mu-Cl)](2). compound (bzox = benzaldehydeoxime) with ethylenethiourea (L) in the 1:2 molar ratio at room temperature yielded the cyclopalladated compound [Pd(C-2,N-bzox)(Cl)(L)] (1) whose replacement of the halide group by the addition of suitable salts afforded compounds of general formulae [Pd((C-2,N-bzox)(X)(L)] = {X = Br- (2), I-(3)}. All compounds were characterized by melting point, elemental analyses, infrared and H-1- and C-13{H-1}-NMR spectroscopies revealing the complexes formation with the oxime coordinated to Pd(II) as C,N-chelating and the ethylenethiourea as a monodentate ligand via the sulfur atom. Hie cytotoxicity of cyclopalladated compounds has been evaluated in vitro against murine mammary tumor cell (LM3) showing cytotoxic activity similar to cisplatin. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 2019-10-04T12:32:48Z 2019-10-04T12:32:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.21577/0100-4042.20170293 Quimica Nova. Sao Paulo: Soc Brasileira Quimica, v. 41, n. 10, p. 1150-1155, 2018. 0100-4042 http://hdl.handle.net/11449/185128 10.21577/0100-4042.20170293 S0100-40422018001001150 WOS:000451630400008 S0100-40422018001001150.pdf |
url |
http://dx.doi.org/10.21577/0100-4042.20170293 http://hdl.handle.net/11449/185128 |
identifier_str_mv |
Quimica Nova. Sao Paulo: Soc Brasileira Quimica, v. 41, n. 10, p. 1150-1155, 2018. 0100-4042 10.21577/0100-4042.20170293 S0100-40422018001001150 WOS:000451630400008 S0100-40422018001001150.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Quimica Nova |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1150-1155 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasileira Quimica |
publisher.none.fl_str_mv |
Soc Brasileira Quimica |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129195331551232 |