Efeitos da administração de eritropoietina na dislipidemia e na hipertrofia ventricular esquerda de camundongos hiperlipidêmicos

• Autor(a) principal: Rosa, Bruno Barbosa
• Data de Publicação: 2014
• Outros Autores: Terra, Gerusa Dias Siqueira Vilela, Garcia, José Antonio Dias, Neiva, Cassiano Merussi [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/2597; http://hdl.handle.net/11449/135443
• topic: Dislipidemy; Left ventricular hypertrophy; Erythropoietin; Mice LDLr-/-; Dislipidemia; Hipertrofia ventricular esquerda; Eritropoietina; Camundongos LDLr-/-

The main purpose of this work was to evaluate the effects of erythropoietin (EPO) on the lipid profile and in left ventricular hypertrophy (LVH) in mice LDLr-/-, fed a high fat diet. Were used twenty-four mice LDLr- / -, male, 3 months old, proportionally divided in 3 groups: S Group, fed with standard diet; HL Group, fed with high fat diet (20% fat total and 1.25% cholesterol, 0.5% cholic acid); HL + EPO Group, fed with high-fat diet and treated with EPO on weekly dose of 200UIkg, subcutaneously. After 75 days of experiment the development of LVH, serum concentrations of glucose, triglycerides (TG), total cholesterol (TC), and low, very low and high density lipoprotein (LDL, VLDL and HDL, respectively) in addition to the left ventricular mass ratio and the total mass of the animal (ventricular mass(mg)/total animal mass(g)) were evaluated. The experimental protocol was approved by the University Ethics Committee of the Experimental Studies under the number 13A/2010. At the end of the trial period, the mice of the HL presented development of LVH with increase in serum concentrations of CT, LDL, VLDL, TG and glucose and a decreased of HDL concentrations, when compared with parameters of mice of the Group S. The use of EPO by HL+EPO group increased serum concentrations of HDL, compared with the HL group (p<0,05) and prevented LVH. In addition, reduced the serum concentrations of TC, LDL, and glucose (p<0,05). However, EPO was not efficient in preventing the hypertriglyceridemia and still, wasn’t able to reduce VLDL concentrations induced by the diet HL. In conclusion, the EPO presented some cardio protective effects, preventing the HVE as well as correcting some of the biochemical variables diet HL-induced. These effects may be, in part, related to increased plasma concentrations of HDL.