Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0074-02760170171 http://hdl.handle.net/11449/165997 |
Resumo: | Visceral leishmaniasis (VL) is fatal if left untreated. Infected dogs are important reservoirs of the disease, and thus specific identification of infected animals is very important. Several diagnostic tests have been developed for canine VL (CVL); however, these tests show varied specificity and sensitivity. The present study describes the recombinant protein rLc36, expressed by Leishmania infantum, as potential antigen for more sensitive and specific diagnosis of CVL based on an immunoenzymatic assay. The concentration of 1.0 mu g/mL of rLc36 enabled differentiation of positive and negative sera and showed a sensitivity of 85% and specificity of 71% (with 95% confidence), with an accuracy of 76%. |
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Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasiscanine visceral leishmaniasisimmunodiagnosisrecombinant proteinVisceral leishmaniasis (VL) is fatal if left untreated. Infected dogs are important reservoirs of the disease, and thus specific identification of infected animals is very important. Several diagnostic tests have been developed for canine VL (CVL); however, these tests show varied specificity and sensitivity. The present study describes the recombinant protein rLc36, expressed by Leishmania infantum, as potential antigen for more sensitive and specific diagnosis of CVL based on an immunoenzymatic assay. The concentration of 1.0 mu g/mL of rLc36 enabled differentiation of positive and negative sera and showed a sensitivity of 85% and specificity of 71% (with 95% confidence), with an accuracy of 76%.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)PADCUniv Estadual Paulista, Inst Quim, Campus Araraquara, Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Campus Araraquara, Araraquara, SP, BrazilUniv Sao Paulo, Inst Quim, Campus Sao Carlos, Sao Carlos, SP, BrazilUniv Estadual Paulista, Fac Ciencias Agr & Vet, Campus Jaboticabal, Jaboticabal, SP, BrazilUniv Estadual Paulista, Inst Biociencias, Campus Rio Claro, Rio Claro, SP, BrazilUniv Fed Sao Carlos, Dept Genet & Evolucao, Sao Carlos, SP, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, Campus Botucatu, Botucatu, SP, BrazilUniv Estadual Paulista, Inst Quim, Campus Araraquara, Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Campus Araraquara, Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Agr & Vet, Campus Jaboticabal, Jaboticabal, SP, BrazilUniv Estadual Paulista, Inst Biociencias, Campus Rio Claro, Rio Claro, SP, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, Campus Botucatu, Botucatu, SP, BrazilFAPESP: 2010/26732-2FAPESP: 2011/06995-9FAPESP: 2011/15508-4Fundaco Oswaldo CruzUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Universidade Federal de São Carlos (UFSCar)Nogueira, Camila Tita [UNESP]Del Cistia, Mayara Lucia [UNESP]Urbaczek, Ana CarolinaJusi, Marcia M. G. [UNESP]Arenas Velasquez, Angela Maria [UNESP]Machado, Rosangela Zacarias [UNESP]Ferreira, Henrique [UNESP]Henrique-Silva, FlavioLangoni, Helio [UNESP]Costa, Paulo Inacio da [UNESP]Graminha, Marcia A. S. [UNESP]2018-11-29T06:59:19Z2018-11-29T06:59:19Z2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article197-201application/pdfhttp://dx.doi.org/10.1590/0074-02760170171Memorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 113, n. 3, p. 197-201, 2018.0074-0276http://hdl.handle.net/11449/16599710.1590/0074-02760170171S0074-02762018000300197WOS:000424492000008S0074-02762018000300197.pdf67202237159173810000-0002-3350-8308Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMemorias Do Instituto Oswaldo Cruzinfo:eu-repo/semantics/openAccess2024-01-23T07:13:37Zoai:repositorio.unesp.br:11449/165997Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-23T07:13:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis |
title |
Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis |
spellingShingle |
Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis Nogueira, Camila Tita [UNESP] canine visceral leishmaniasis immunodiagnosis recombinant protein |
title_short |
Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis |
title_full |
Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis |
title_fullStr |
Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis |
title_full_unstemmed |
Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis |
title_sort |
Potential application of rLc36 protein for diagnosis of canine visceral leishmaniasis |
author |
Nogueira, Camila Tita [UNESP] |
author_facet |
Nogueira, Camila Tita [UNESP] Del Cistia, Mayara Lucia [UNESP] Urbaczek, Ana Carolina Jusi, Marcia M. G. [UNESP] Arenas Velasquez, Angela Maria [UNESP] Machado, Rosangela Zacarias [UNESP] Ferreira, Henrique [UNESP] Henrique-Silva, Flavio Langoni, Helio [UNESP] Costa, Paulo Inacio da [UNESP] Graminha, Marcia A. S. [UNESP] |
author_role |
author |
author2 |
Del Cistia, Mayara Lucia [UNESP] Urbaczek, Ana Carolina Jusi, Marcia M. G. [UNESP] Arenas Velasquez, Angela Maria [UNESP] Machado, Rosangela Zacarias [UNESP] Ferreira, Henrique [UNESP] Henrique-Silva, Flavio Langoni, Helio [UNESP] Costa, Paulo Inacio da [UNESP] Graminha, Marcia A. S. [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Universidade Federal de São Carlos (UFSCar) |
dc.contributor.author.fl_str_mv |
Nogueira, Camila Tita [UNESP] Del Cistia, Mayara Lucia [UNESP] Urbaczek, Ana Carolina Jusi, Marcia M. G. [UNESP] Arenas Velasquez, Angela Maria [UNESP] Machado, Rosangela Zacarias [UNESP] Ferreira, Henrique [UNESP] Henrique-Silva, Flavio Langoni, Helio [UNESP] Costa, Paulo Inacio da [UNESP] Graminha, Marcia A. S. [UNESP] |
dc.subject.por.fl_str_mv |
canine visceral leishmaniasis immunodiagnosis recombinant protein |
topic |
canine visceral leishmaniasis immunodiagnosis recombinant protein |
description |
Visceral leishmaniasis (VL) is fatal if left untreated. Infected dogs are important reservoirs of the disease, and thus specific identification of infected animals is very important. Several diagnostic tests have been developed for canine VL (CVL); however, these tests show varied specificity and sensitivity. The present study describes the recombinant protein rLc36, expressed by Leishmania infantum, as potential antigen for more sensitive and specific diagnosis of CVL based on an immunoenzymatic assay. The concentration of 1.0 mu g/mL of rLc36 enabled differentiation of positive and negative sera and showed a sensitivity of 85% and specificity of 71% (with 95% confidence), with an accuracy of 76%. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-29T06:59:19Z 2018-11-29T06:59:19Z 2018-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0074-02760170171 Memorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 113, n. 3, p. 197-201, 2018. 0074-0276 http://hdl.handle.net/11449/165997 10.1590/0074-02760170171 S0074-02762018000300197 WOS:000424492000008 S0074-02762018000300197.pdf 6720223715917381 0000-0002-3350-8308 |
url |
http://dx.doi.org/10.1590/0074-02760170171 http://hdl.handle.net/11449/165997 |
identifier_str_mv |
Memorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 113, n. 3, p. 197-201, 2018. 0074-0276 10.1590/0074-02760170171 S0074-02762018000300197 WOS:000424492000008 S0074-02762018000300197.pdf 6720223715917381 0000-0002-3350-8308 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Memorias Do Instituto Oswaldo Cruz |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
197-201 application/pdf |
dc.publisher.none.fl_str_mv |
Fundaco Oswaldo Cruz |
publisher.none.fl_str_mv |
Fundaco Oswaldo Cruz |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965709253476352 |