CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA

Detalhes bibliográficos
Autor(a) principal: Deoliveira, S. L.
Data de Publicação: 1993
Outros Autores: Dasilva, M. F., Soares, AMVD, Silva, C. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/197287
Resumo: The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the F1 fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis.
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spelling CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIABETA-GLUCANCELL WALLHYPERGAMMAGLOBULINEMIAPARACOCCIDIOIDOMYCOSISPARACOCCIDIOIDES-BRASILIENSISThe antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the F1 fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis.UNIV SAO PAULO, SCH MED RIBEIRAO PRETO, DEPT PARASITOL MICROBIOL & IMMUNOL, BR-14049 RIBEIRAO PRETO, SP, BRAZILUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, DEPT MICROBIOL & IMMUNOL, BOTUCATU, SP, BRAZILUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, DEPT MICROBIOL & IMMUNOL, BOTUCATU, SP, BRAZILSpringerUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Deoliveira, S. L.Dasilva, M. F.Soares, AMVDSilva, C. L.2020-12-10T20:12:09Z2020-12-10T20:12:09Z1993-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-5Mycopathologia. Dordrecht: Springer, v. 121, n. 1, p. 1-5, 1993.0301-486Xhttp://hdl.handle.net/11449/197287WOS:A1993KK24300001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMycopathologiainfo:eu-repo/semantics/openAccess2021-10-23T12:31:47Zoai:repositorio.unesp.br:11449/197287Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:22:37.705759Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
title CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
spellingShingle CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
Deoliveira, S. L.
BETA-GLUCAN
CELL WALL
HYPERGAMMAGLOBULINEMIA
PARACOCCIDIOIDOMYCOSIS
PARACOCCIDIOIDES-BRASILIENSIS
title_short CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
title_full CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
title_fullStr CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
title_full_unstemmed CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
title_sort CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
author Deoliveira, S. L.
author_facet Deoliveira, S. L.
Dasilva, M. F.
Soares, AMVD
Silva, C. L.
author_role author
author2 Dasilva, M. F.
Soares, AMVD
Silva, C. L.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Deoliveira, S. L.
Dasilva, M. F.
Soares, AMVD
Silva, C. L.
dc.subject.por.fl_str_mv BETA-GLUCAN
CELL WALL
HYPERGAMMAGLOBULINEMIA
PARACOCCIDIOIDOMYCOSIS
PARACOCCIDIOIDES-BRASILIENSIS
topic BETA-GLUCAN
CELL WALL
HYPERGAMMAGLOBULINEMIA
PARACOCCIDIOIDOMYCOSIS
PARACOCCIDIOIDES-BRASILIENSIS
description The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the F1 fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis.
publishDate 1993
dc.date.none.fl_str_mv 1993-01-01
2020-12-10T20:12:09Z
2020-12-10T20:12:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Mycopathologia. Dordrecht: Springer, v. 121, n. 1, p. 1-5, 1993.
0301-486X
http://hdl.handle.net/11449/197287
WOS:A1993KK24300001
identifier_str_mv Mycopathologia. Dordrecht: Springer, v. 121, n. 1, p. 1-5, 1993.
0301-486X
WOS:A1993KK24300001
url http://hdl.handle.net/11449/197287
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mycopathologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-5
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128640285671424

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