Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli
Autor(a) principal: | |
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Data de Publicação: | 1994 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/223986 |
Resumo: | We investigated the effects of ramipril, an angiotensin I-converting enzyme (ACE) inhibitor, on water intake by male Holtzman rats (250-300 g) with cannulae implanted into the lateral ventricle. Intracerebroventricular (icv) injection of ramipril (1 μg/μl) significantly reduced drinking in response to subcutaneous (sc) injection of isoprenaline (100 μg/kg) from 8.49 ± 0.69 to 2.96 ± 0.36 ml/2 h, polyethyleneglycol (PEG) (30% w/v, 10 ml/kg) from 9.51 ± 2.20 to 1.6 ± 0.34 ml/2 h or water deprivation for 24 h from 12.61 ± 0.83 to 5.10 ± 1.37 ml/2 h. Ramipril had no effect on water intake induced by cellular dehydration produced by sc injection of hypertonic saline (2 M NaCl). These results are consistent with the hypothesis that ramipril acts as an ACE-blocking agent in the brain. The possibility that ramipril is transformed to ramiprilat, the active drug, by the brain is suggested. |
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Repositório Institucional da UNESP |
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Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuliangiotensincentral nervous systemramiprilwater intakeWe investigated the effects of ramipril, an angiotensin I-converting enzyme (ACE) inhibitor, on water intake by male Holtzman rats (250-300 g) with cannulae implanted into the lateral ventricle. Intracerebroventricular (icv) injection of ramipril (1 μg/μl) significantly reduced drinking in response to subcutaneous (sc) injection of isoprenaline (100 μg/kg) from 8.49 ± 0.69 to 2.96 ± 0.36 ml/2 h, polyethyleneglycol (PEG) (30% w/v, 10 ml/kg) from 9.51 ± 2.20 to 1.6 ± 0.34 ml/2 h or water deprivation for 24 h from 12.61 ± 0.83 to 5.10 ± 1.37 ml/2 h. Ramipril had no effect on water intake induced by cellular dehydration produced by sc injection of hypertonic saline (2 M NaCl). These results are consistent with the hypothesis that ramipril acts as an ACE-blocking agent in the brain. The possibility that ramipril is transformed to ramiprilat, the active drug, by the brain is suggested.Dpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humaita, 1680, 14801-903 Araraquara, SPDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humaita, 1680, 14801-903 Araraquara, SPUniversidade Estadual Paulista (UNESP)Saad, W. A. [UNESP]Luiz, A. C. [UNESP]Camargo, L. A.A. [UNESP]Menani, J. V. [UNESP]Renzi, A. [UNESP]Silveira, J. E.N. [UNESP]Paulino, M. A. [UNESP]2022-04-28T19:54:02Z2022-04-28T19:54:02Z1994-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2909-2913Brazilian Journal of Medical and Biological Research, v. 27, n. 12, p. 2909-2913, 1994.0100-879Xhttp://hdl.handle.net/11449/2239862-s2.0-0028576495Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccess2022-04-28T19:54:02Zoai:repositorio.unesp.br:11449/223986Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:00:48.302651Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli |
title |
Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli |
spellingShingle |
Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli Saad, W. A. [UNESP] angiotensin central nervous system ramipril water intake |
title_short |
Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli |
title_full |
Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli |
title_fullStr |
Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli |
title_full_unstemmed |
Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli |
title_sort |
Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli |
author |
Saad, W. A. [UNESP] |
author_facet |
Saad, W. A. [UNESP] Luiz, A. C. [UNESP] Camargo, L. A.A. [UNESP] Menani, J. V. [UNESP] Renzi, A. [UNESP] Silveira, J. E.N. [UNESP] Paulino, M. A. [UNESP] |
author_role |
author |
author2 |
Luiz, A. C. [UNESP] Camargo, L. A.A. [UNESP] Menani, J. V. [UNESP] Renzi, A. [UNESP] Silveira, J. E.N. [UNESP] Paulino, M. A. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Saad, W. A. [UNESP] Luiz, A. C. [UNESP] Camargo, L. A.A. [UNESP] Menani, J. V. [UNESP] Renzi, A. [UNESP] Silveira, J. E.N. [UNESP] Paulino, M. A. [UNESP] |
dc.subject.por.fl_str_mv |
angiotensin central nervous system ramipril water intake |
topic |
angiotensin central nervous system ramipril water intake |
description |
We investigated the effects of ramipril, an angiotensin I-converting enzyme (ACE) inhibitor, on water intake by male Holtzman rats (250-300 g) with cannulae implanted into the lateral ventricle. Intracerebroventricular (icv) injection of ramipril (1 μg/μl) significantly reduced drinking in response to subcutaneous (sc) injection of isoprenaline (100 μg/kg) from 8.49 ± 0.69 to 2.96 ± 0.36 ml/2 h, polyethyleneglycol (PEG) (30% w/v, 10 ml/kg) from 9.51 ± 2.20 to 1.6 ± 0.34 ml/2 h or water deprivation for 24 h from 12.61 ± 0.83 to 5.10 ± 1.37 ml/2 h. Ramipril had no effect on water intake induced by cellular dehydration produced by sc injection of hypertonic saline (2 M NaCl). These results are consistent with the hypothesis that ramipril acts as an ACE-blocking agent in the brain. The possibility that ramipril is transformed to ramiprilat, the active drug, by the brain is suggested. |
publishDate |
1994 |
dc.date.none.fl_str_mv |
1994-12-01 2022-04-28T19:54:02Z 2022-04-28T19:54:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Brazilian Journal of Medical and Biological Research, v. 27, n. 12, p. 2909-2913, 1994. 0100-879X http://hdl.handle.net/11449/223986 2-s2.0-0028576495 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research, v. 27, n. 12, p. 2909-2913, 1994. 0100-879X 2-s2.0-0028576495 |
url |
http://hdl.handle.net/11449/223986 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2909-2913 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128593754062848 |