Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0037-8682-0198-2013 http://hdl.handle.net/11449/109823 |
Resumo: | Introduction Visceral leishmaniasis (VL) is caused by the intracellular protozoan Leishmania donovani complex. VL may be asymptomatic or progressive and is characterized by fever, anemia, weight loss and the enlargement of the spleen and liver. The nutritional status of the patients with VL is a major determinant of the progression, severity and mortality of the disease, as it affects the clinical progression of the disease. Changes in lipoproteins and plasma proteins may have major impacts in the host during infection. Thus, our goal was evaluate the serum total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, glucose, albumin, globulin and total protein levels, as well as the body composition, of VL patients before and after treatment. Methods Nutritional evaluation was performed using the bioelectrical impedance analysis (BIA) to assess body composition. Biochemical data on the serum total cholesterol, HDL, LDL, triglycerides, glucose, albumin, globulin and total protein were collected from the medical charts of the patients. Results BIA indicated that both pre-treatment and post-treatment patients exhibited decreased phase angles compared to the controls, which is indicative of disease. Prior to treatment, the patients exhibited lower levels of total body water compared to the controls. Regarding the biochemical evaluation, patients with active VL exhibited lower levels of total cholesterol, HDL, LDL and albumin and higher triglyceride levels compared to patients after treatment and the controls. Treatment increased the levels of albumin and lipoproteins and decreased the triglyceride levels. Conclusions Our results suggest that patients with active VL present biochemical and nutritional changes that are reversed by treatment. |
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Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugsVisceral leishmaniasisNutritional statusLeishmanicidal drugsIntroduction Visceral leishmaniasis (VL) is caused by the intracellular protozoan Leishmania donovani complex. VL may be asymptomatic or progressive and is characterized by fever, anemia, weight loss and the enlargement of the spleen and liver. The nutritional status of the patients with VL is a major determinant of the progression, severity and mortality of the disease, as it affects the clinical progression of the disease. Changes in lipoproteins and plasma proteins may have major impacts in the host during infection. Thus, our goal was evaluate the serum total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, glucose, albumin, globulin and total protein levels, as well as the body composition, of VL patients before and after treatment. Methods Nutritional evaluation was performed using the bioelectrical impedance analysis (BIA) to assess body composition. Biochemical data on the serum total cholesterol, HDL, LDL, triglycerides, glucose, albumin, globulin and total protein were collected from the medical charts of the patients. Results BIA indicated that both pre-treatment and post-treatment patients exhibited decreased phase angles compared to the controls, which is indicative of disease. Prior to treatment, the patients exhibited lower levels of total body water compared to the controls. Regarding the biochemical evaluation, patients with active VL exhibited lower levels of total cholesterol, HDL, LDL and albumin and higher triglyceride levels compared to patients after treatment and the controls. Treatment increased the levels of albumin and lipoproteins and decreased the triglyceride levels. Conclusions Our results suggest that patients with active VL present biochemical and nutritional changes that are reversed by treatment.Universidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Doencas TropicaisHospital Estadual de Bauru Setor de Molestias InfecciosasUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Doencas TropicaisSociedade Brasileira de Medicina Tropical - SBMTUniversidade Estadual Paulista (Unesp)Hospital Estadual de Bauru Setor de Molestias InfecciosasGatto, MarianaAbreu, Mariana Miziara DeTasca, Karen IngridSimao, Jose ClaudioFortaleza, Carlos Magno Castelo Branco [UNESP]Pereira, Paulo Câmara Marques [UNESP]Calvi, Sueli Aparecida [UNESP]2014-10-01T13:08:35Z2014-10-01T13:08:35Z2013-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article735-740application/pdfhttp://dx.doi.org/10.1590/0037-8682-0198-2013Revista da Sociedade Brasileira de Medicina Tropical. Sociedade Brasileira de Medicina Tropical - SBMT, v. 46, n. 6, p. 735-740, 2013.0037-8682http://hdl.handle.net/11449/10982310.1590/0037-8682-0198-2013S0037-86822013000600735WOS:000330539200011S0037-86822013000600735.pdf136532042741820421794500226990590000-0001-5771-8943SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Sociedade Brasileira de Medicina Tropical1.3580,658info:eu-repo/semantics/openAccess2023-11-25T06:12:15Zoai:repositorio.unesp.br:11449/109823Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-25T06:12:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs |
title |
Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs |
spellingShingle |
Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs Gatto, Mariana Visceral leishmaniasis Nutritional status Leishmanicidal drugs |
title_short |
Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs |
title_full |
Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs |
title_fullStr |
Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs |
title_full_unstemmed |
Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs |
title_sort |
Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs |
author |
Gatto, Mariana |
author_facet |
Gatto, Mariana Abreu, Mariana Miziara De Tasca, Karen Ingrid Simao, Jose Claudio Fortaleza, Carlos Magno Castelo Branco [UNESP] Pereira, Paulo Câmara Marques [UNESP] Calvi, Sueli Aparecida [UNESP] |
author_role |
author |
author2 |
Abreu, Mariana Miziara De Tasca, Karen Ingrid Simao, Jose Claudio Fortaleza, Carlos Magno Castelo Branco [UNESP] Pereira, Paulo Câmara Marques [UNESP] Calvi, Sueli Aparecida [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Hospital Estadual de Bauru Setor de Molestias Infecciosas |
dc.contributor.author.fl_str_mv |
Gatto, Mariana Abreu, Mariana Miziara De Tasca, Karen Ingrid Simao, Jose Claudio Fortaleza, Carlos Magno Castelo Branco [UNESP] Pereira, Paulo Câmara Marques [UNESP] Calvi, Sueli Aparecida [UNESP] |
dc.subject.por.fl_str_mv |
Visceral leishmaniasis Nutritional status Leishmanicidal drugs |
topic |
Visceral leishmaniasis Nutritional status Leishmanicidal drugs |
description |
Introduction Visceral leishmaniasis (VL) is caused by the intracellular protozoan Leishmania donovani complex. VL may be asymptomatic or progressive and is characterized by fever, anemia, weight loss and the enlargement of the spleen and liver. The nutritional status of the patients with VL is a major determinant of the progression, severity and mortality of the disease, as it affects the clinical progression of the disease. Changes in lipoproteins and plasma proteins may have major impacts in the host during infection. Thus, our goal was evaluate the serum total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, glucose, albumin, globulin and total protein levels, as well as the body composition, of VL patients before and after treatment. Methods Nutritional evaluation was performed using the bioelectrical impedance analysis (BIA) to assess body composition. Biochemical data on the serum total cholesterol, HDL, LDL, triglycerides, glucose, albumin, globulin and total protein were collected from the medical charts of the patients. Results BIA indicated that both pre-treatment and post-treatment patients exhibited decreased phase angles compared to the controls, which is indicative of disease. Prior to treatment, the patients exhibited lower levels of total body water compared to the controls. Regarding the biochemical evaluation, patients with active VL exhibited lower levels of total cholesterol, HDL, LDL and albumin and higher triglyceride levels compared to patients after treatment and the controls. Treatment increased the levels of albumin and lipoproteins and decreased the triglyceride levels. Conclusions Our results suggest that patients with active VL present biochemical and nutritional changes that are reversed by treatment. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-01 2014-10-01T13:08:35Z 2014-10-01T13:08:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0037-8682-0198-2013 Revista da Sociedade Brasileira de Medicina Tropical. Sociedade Brasileira de Medicina Tropical - SBMT, v. 46, n. 6, p. 735-740, 2013. 0037-8682 http://hdl.handle.net/11449/109823 10.1590/0037-8682-0198-2013 S0037-86822013000600735 WOS:000330539200011 S0037-86822013000600735.pdf 1365320427418204 2179450022699059 0000-0001-5771-8943 |
url |
http://dx.doi.org/10.1590/0037-8682-0198-2013 http://hdl.handle.net/11449/109823 |
identifier_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical. Sociedade Brasileira de Medicina Tropical - SBMT, v. 46, n. 6, p. 735-740, 2013. 0037-8682 10.1590/0037-8682-0198-2013 S0037-86822013000600735 WOS:000330539200011 S0037-86822013000600735.pdf 1365320427418204 2179450022699059 0000-0001-5771-8943 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical 1.358 0,658 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
735-740 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965060566614016 |