Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bone.2015.11.014 http://hdl.handle.net/11449/172283 |
Resumo: | Periodontal pathogens and/or inflammatory products from periodontitis participate in the development or progression of systemic diseases. In this context, periodontitis acts as a modifying factor to systemic health, including diabetes and cardiovascular diseases. Osteoporosis is an increasingly prevalent condition in our aging population and considered a risk factor for periodontal disease, but the effect of periodontitis on systemic bone homeostasis is unknown. We thus evaluated the effects of experimental periodontitis (EP) on systemic bone loss and the influence of estrogen deficiency in this context, using a mouse model of combined periodontitis and osteoporosis. Experimental periodontitis (EP) was induced by a ligature insertion around the mandibular first molars and Porphyromonas gingivalis infection. Three-dimensional microcomputed tomographic analyses performed 48 days following infection revealed that EP and ovariectomy (OVX) induced a significantly higher femoral and mandibular bone loss compared to EP or OVX alone. EP alone did not induce systemic bone loss. In addition, the EP. +. OVX and EP groups showed significantly higher levels of tumor necrosis factor (TNF)-α than OVX and control groups at end point. These results suggest that periodontitis could be a risk factor for systemic bone loss, especially in post-menopausal women, and warrant further clinical investigations to confirm this association and propose adapted prophylactic and curative therapies. |
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Periodontal disease exacerbates systemic ovariectomy-induced bone loss in miceFracture riskOsteoporosisOvariectomyPeriodontitisTNF-αPeriodontal pathogens and/or inflammatory products from periodontitis participate in the development or progression of systemic diseases. In this context, periodontitis acts as a modifying factor to systemic health, including diabetes and cardiovascular diseases. Osteoporosis is an increasingly prevalent condition in our aging population and considered a risk factor for periodontal disease, but the effect of periodontitis on systemic bone homeostasis is unknown. We thus evaluated the effects of experimental periodontitis (EP) on systemic bone loss and the influence of estrogen deficiency in this context, using a mouse model of combined periodontitis and osteoporosis. Experimental periodontitis (EP) was induced by a ligature insertion around the mandibular first molars and Porphyromonas gingivalis infection. Three-dimensional microcomputed tomographic analyses performed 48 days following infection revealed that EP and ovariectomy (OVX) induced a significantly higher femoral and mandibular bone loss compared to EP or OVX alone. EP alone did not induce systemic bone loss. In addition, the EP. +. OVX and EP groups showed significantly higher levels of tumor necrosis factor (TNF)-α than OVX and control groups at end point. These results suggest that periodontitis could be a risk factor for systemic bone loss, especially in post-menopausal women, and warrant further clinical investigations to confirm this association and propose adapted prophylactic and curative therapies.Department of Bioscience and Oral Diagnosis Institute of Science and Technology of São José dos Campos Univ Estadual Paulista-UNESP, São José dos CamposVanderbilt Center for Bone Biology Department of Medicine Department of Pharmacology and Department of Cancer BiologyBaylor College of Medicine Department of Molecular and Human Genetics and Orthopedic Surgery, One Baylor PlazaDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology of São José dos Campos Univ Estadual Paulista-UNESP, São José dos CamposUniversidade Estadual Paulista (Unesp)Department of MedicineBaylor College of MedicineAnbinder, Ana Lia [UNESP]Moraes, Renata M. [UNESP]Lima, Gabriela M.G. [UNESP]Oliveira, Felipe E. [UNESP]Campos, Débora R.C. [UNESP]Rossoni, Rodnei D. [UNESP]Oliveira, Luciane D. [UNESP]Junqueira, Juliana C. [UNESP]Ma, YunElefteriou, Florent2018-12-11T16:59:31Z2018-12-11T16:59:31Z2016-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article241-247application/pdfhttp://dx.doi.org/10.1016/j.bone.2015.11.014Bone, v. 83, p. 241-247.8756-3282http://hdl.handle.net/11449/17228310.1016/j.bone.2015.11.0142-s2.0-849495220952-s2.0-84949522095.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBone1,652info:eu-repo/semantics/openAccess2023-12-31T06:17:39Zoai:repositorio.unesp.br:11449/172283Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:46:21.984013Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice |
title |
Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice |
spellingShingle |
Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice Anbinder, Ana Lia [UNESP] Fracture risk Osteoporosis Ovariectomy Periodontitis TNF-α |
title_short |
Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice |
title_full |
Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice |
title_fullStr |
Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice |
title_full_unstemmed |
Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice |
title_sort |
Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice |
author |
Anbinder, Ana Lia [UNESP] |
author_facet |
Anbinder, Ana Lia [UNESP] Moraes, Renata M. [UNESP] Lima, Gabriela M.G. [UNESP] Oliveira, Felipe E. [UNESP] Campos, Débora R.C. [UNESP] Rossoni, Rodnei D. [UNESP] Oliveira, Luciane D. [UNESP] Junqueira, Juliana C. [UNESP] Ma, Yun Elefteriou, Florent |
author_role |
author |
author2 |
Moraes, Renata M. [UNESP] Lima, Gabriela M.G. [UNESP] Oliveira, Felipe E. [UNESP] Campos, Débora R.C. [UNESP] Rossoni, Rodnei D. [UNESP] Oliveira, Luciane D. [UNESP] Junqueira, Juliana C. [UNESP] Ma, Yun Elefteriou, Florent |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Department of Medicine Baylor College of Medicine |
dc.contributor.author.fl_str_mv |
Anbinder, Ana Lia [UNESP] Moraes, Renata M. [UNESP] Lima, Gabriela M.G. [UNESP] Oliveira, Felipe E. [UNESP] Campos, Débora R.C. [UNESP] Rossoni, Rodnei D. [UNESP] Oliveira, Luciane D. [UNESP] Junqueira, Juliana C. [UNESP] Ma, Yun Elefteriou, Florent |
dc.subject.por.fl_str_mv |
Fracture risk Osteoporosis Ovariectomy Periodontitis TNF-α |
topic |
Fracture risk Osteoporosis Ovariectomy Periodontitis TNF-α |
description |
Periodontal pathogens and/or inflammatory products from periodontitis participate in the development or progression of systemic diseases. In this context, periodontitis acts as a modifying factor to systemic health, including diabetes and cardiovascular diseases. Osteoporosis is an increasingly prevalent condition in our aging population and considered a risk factor for periodontal disease, but the effect of periodontitis on systemic bone homeostasis is unknown. We thus evaluated the effects of experimental periodontitis (EP) on systemic bone loss and the influence of estrogen deficiency in this context, using a mouse model of combined periodontitis and osteoporosis. Experimental periodontitis (EP) was induced by a ligature insertion around the mandibular first molars and Porphyromonas gingivalis infection. Three-dimensional microcomputed tomographic analyses performed 48 days following infection revealed that EP and ovariectomy (OVX) induced a significantly higher femoral and mandibular bone loss compared to EP or OVX alone. EP alone did not induce systemic bone loss. In addition, the EP. +. OVX and EP groups showed significantly higher levels of tumor necrosis factor (TNF)-α than OVX and control groups at end point. These results suggest that periodontitis could be a risk factor for systemic bone loss, especially in post-menopausal women, and warrant further clinical investigations to confirm this association and propose adapted prophylactic and curative therapies. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-01 2018-12-11T16:59:31Z 2018-12-11T16:59:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bone.2015.11.014 Bone, v. 83, p. 241-247. 8756-3282 http://hdl.handle.net/11449/172283 10.1016/j.bone.2015.11.014 2-s2.0-84949522095 2-s2.0-84949522095.pdf |
url |
http://dx.doi.org/10.1016/j.bone.2015.11.014 http://hdl.handle.net/11449/172283 |
identifier_str_mv |
Bone, v. 83, p. 241-247. 8756-3282 10.1016/j.bone.2015.11.014 2-s2.0-84949522095 2-s2.0-84949522095.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bone 1,652 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
241-247 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128235773362176 |